Compounds > 4-(3-((2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid
Page last updated: 2024-11-08

4-(3-((2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid

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Description

4-(3-((2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid: isosterically modified prostaglandin analog; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID175027
CHEMBL ID116327
SCHEMBL ID9817196
MeSH IDM0108190

Synonyms (22)

Synonym
l 644122
CHEMBL116327
4-[3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-1,3-thiazolidin-2-yl]propyl]benzoic acid
unii-8fr918m34p
8fr918m34p ,
4-(3-((2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid
4-hctpb
l-644,122
72313-44-1
benzoic acid, 4-(3-(3-(2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)-
SCHEMBL9817196
(+/-)-4-[3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl]benzoic acid
4-{3-[3-[2-(1-hydroxycyclohexyl)-ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic acid
(+/-)-4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic acid
4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazoldinyl]propyl}benzoic acid
BCZCFHAXZSPKAV-UHFFFAOYSA-N
4-{3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl}benzoic acid
DTXSID80993103
4-(3-{3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-1,3-thiazolidin-2-yl}propyl)benzoic acid
l-644122, (+/-)-
4-(3-(3-(2-(1-hydroxycyclohexyl)ethyl)-4-oxo-2-thiazolidinyl)propyl)benzoic acid
PD160174
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID59760Effect on lower aortic blood flow in conscious dogs dosed at 5 mg/kg, observed at 2-3 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59761Effect on lower aortic blood flow in conscious dogs dosed at 5 mg/kg, observed at 3-4 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID61296Percent change in renal plasma flow in conscious dogs dosed at 0.1 mg/kg1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID61300Percent change in renal resistance in anesthetized dogs after infusion of compound at 10 nM/kg/min1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID61295Percent change in renal plasma flow in conscious dogs dosed at 0.05 mg/kg1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID57483Effect on renal plasma flow in conscious dogs dosed at 0.2 mg/kg (post-treatment)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59744Effect on lower arterial blood pressure in conscious dogs dosed at 5 mg/kg, observed at 1-2 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID57482Effect on renal plasma flow in conscious dogs dosed at 0.1 mg/kg (pretreatment)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59766Effect on renal blood flow in conscious dogs dosed at 5 mg/kg, observed at 3-4 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59756Effect on heart rate in conscious dogs dosed at 5 mg/kg, observed at 3-4 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID57479Effect on renal plasma flow in conscious dogs dosed at 0.05 mg/kg (post-treatment)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59745Effect on lower arterial blood pressure in conscious dogs dosed at 5 mg/kg, observed at 2-3 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59762Effect on lower aortic blood flow in conscious dogs dosed at 5 mg/kg, observed at 4-5 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59747Effect on lower arterial blood pressure in conscious dogs dosed at 5 mg/kg, observed at 4-5 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID57481Effect on renal plasma flow in conscious dogs dosed at 0.1 mg/kg (post-treatment)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID57484Effect on renal plasma flow in conscious dogs dosed at 0.2 mg/kg (pretreatment)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59758Effect on lower aortic blood flow in conscious dogs dosed at 5 mg/kg, observed at 0-1 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID61419Percent change in renal resistance in anesthetized dogs after infusion of compound at 25 nM/kg/min1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59759Effect on lower aortic blood flow in conscious dogs dosed at 5 mg/kg, observed at 1-2 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59743Effect on lower arterial blood pressure in conscious dogs dosed at 5 mg/kg, observed at 0-1 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59746Effect on lower arterial blood pressure in conscious dogs dosed at 5 mg/kg, observed at 3-4 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID61297Percent change in renal plasma flow in conscious dogs dosed at 0.2 mg/kg1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59764Effect on renal blood flow in conscious dogs dosed at 5 mg/kg, observed at 1-2 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59763Effect on renal blood flow in conscious dogs dosed at 5 mg/kg, observed at 0-1 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59767Effect on renal blood flow in conscious dogs dosed at 5 mg/kg, observed at 4-5 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59753Effect on heart rate in conscious dogs dosed at 5 mg/kg, observed at 0-1 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59755Effect on heart rate in conscious dogs dosed at 5 mg/kg, observed at 2-3 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID57480Effect on renal plasma flow in conscious dogs dosed at 0.05 mg/kg (pretreatment)1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59757Effect on heart rate in conscious dogs dosed at 5 mg/kg, observed at 4-5 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID61420Percent change in renal resistance in anesthetized dogs after infusion of compound at 50 nM/kg/min1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59765Effect on renal blood flow in conscious dogs dosed at 5 mg/kg, observed at 2-3 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
AID59754Effect on heart rate in conscious dogs dosed at 5 mg/kg, observed at 1-2 h1983Journal of medicinal chemistry, Mar, Volume: 26, Issue:3
Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogues as renal vasodilators.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.05 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (11.11%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fenoldopam
Fenoldopam: A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.		1.9610benzazepinealpha-adrenergic agonist;
antihypertensive agent;
dopamine agonist;
dopaminergic antagonist;
vasodilator agent
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9610aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
deoxyepinephrine
Deoxyepinephrine: Sympathomimetic, vasoconstrictor agent.		1.9610catecholamine
phenoxybenzamine
Phenoxybenzamine: An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator.		2.3720aromatic amine
carbachol
Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.		1.9610ammonium salt;
carbamate ester		cardiotonic drug;
miotic;
muscarinic agonist;
nicotinic acetylcholine receptor agonist;
non-narcotic analgesic
thiazoles
[no description available]		4.96911,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		4.9691thiazolidine
timolol
(S)-timolol (anhydrous) : The (S)-(-) (more active) enantiomer of timolol. A beta-adrenergic antagonist, both the hemihydrate and the maleate salt are used in the mangement of glaucoma, hypertension, angina pectoris and myocardial infarction, and for the prevention of migraine.		1.9610timololanti-arrhythmia drug;
antiglaucoma drug;
antihypertensive agent;
beta-adrenergic antagonist
ibopamine
ibopamine: structure given in UD 31;67a & in 2nd source		1.9610benzoate ester;
phenols
prostaglandin d2
Prostaglandin D2: The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.. prostaglandin D2 : A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).		1.9610prostaglandins Dhuman metabolite;
mouse metabolite
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.6530prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
dinoprost
Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.		1.9610monocarboxylic acid;
prostaglandins Falpha		human metabolite;
mouse metabolite
prostaglandin f2beta
prostaglandin F2beta: RN given refers to (5Z,9 beta,11 alpha,13E,15S)-isomer. prostaglandin F2beta : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is the 9beta-hydroxy epimer of prostaglandin F2alpha.		1.9610prostaglandins Fbetahuman metabolite
15-ketoprostaglandin f2alpha
[no description available]		1.9610prostaglandins Falpha
prostaglandin f1
prostaglandin F1: was EN to PROSTAGLANDINS F (75-81); RN given refers to (9 alpha,11 alpha,13E,15S)-isomer		1.9610prostaglandins Falphahuman metabolite
dinoprost tromethamine
[no description available]		1.9610organic molecular entity
prostaglandin f2 isopropyl ester
prostaglandin F2 isopropyl ester: has ocular hypotensive effect		1.9610prostanoid
prostaglandin f2 methyl ester
prostaglandin F2 methyl ester: has ocular hypotensive effect; RN given refers to (5Z,9alpha,11alpha,13E,15S)-isomer		1.9610prostanoid
u 44069
U 44069: has contractile effect on rat pulmonary veins & arteries; a thromboxane-A2 mimetic		1.9610prostanoid
16,16-dimethylprostaglandin f2alpha
16,16-dimethylprostaglandin F2alpha: RN given refers to (5Z,9alpha,11alpha,13E,15R)-isomer		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.		01.9610
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		01.9610
Intraocular Pressure
The pressure of the fluids in the eye.		01.9610
Blood Pressure, High
[description not available]		03.3511
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		03.3511