4-(2-di-N-propylaminoethyl)indole: stimulates presynaptic dopamine autoreceptors; RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3086054 |
| CHEMBL ID | 67040 |
| SCHEMBL ID | 11177660 |
| MeSH ID | M0120785 |
| Synonym |
|---|
| dpai |
| CHEMBL67040 |
| n-[2-(1h-indol-4-yl)ethyl]-n-propylpropan-1-amine |
| 76149-15-0 |
| 4-dpaei |
| 1h-indole-4-ethanamine, n,n-dipropyl- |
| 4-(2-di-n-propylaminoethyl)indole |
| AFRBPRLOPBAGCM-UHFFFAOYSA-N |
| 4-[2-(dipropylamino)ethyl]indole |
| DTXSID10227004 |
| SCHEMBL11177660 |
| 4-(2-[di-n-propylamino]ethyl)indole |
| [2-(1h-indol-4-yl)ethyl]dipropylamine |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID63633 | Dopamine D2 agonistic activity (2 mg/kg) as plasma prolactin level in reserpinized rats | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9 | Synthesis and evaluation of N,N-di-n-propyltetrahydrobenz[f]indol-7-amine and related congeners as dopaminergic agonists. |
| AID47951 | Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | 6-Hydroxy-4-[2-(di-n-propylamino)ethyl]indole: synthesis and dopaminergic actions. |
| AID61215 | Dopamine D2 agonistic activity (2 mg/kg) as percent change in prolactin level in reserpinized rats | 1989 | Journal of medicinal chemistry, Sep, Volume: 32, Issue:9 | Synthesis and evaluation of N,N-di-n-propyltetrahydrobenz[f]indol-7-amine and related congeners as dopaminergic agonists. |
| AID47948 | Compound tested in vitro for sympathetic neuronal activity in cat atria after iv administration; no inhibition with concentrations uM | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | 6-Hydroxy-4-[2-(di-n-propylamino)ethyl]indole: synthesis and dopaminergic actions. |
| AID62292 | In vivo inhibitory activity against dopamine receptor in isolated cat atria; inactive | 1984 | Journal of medicinal chemistry, Mar, Volume: 27, Issue:3 | 6-Hydroxy-4-[2-(di-n-propylamino)ethyl]indole: synthesis and dopaminergic actions. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.21) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||