Page last updated: 2024-12-07

3-phenylindole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

3-phenylindole is a heterocyclic organic compound with the formula C14H11N. It is a white solid that is sparingly soluble in water. 3-phenylindole is a versatile building block in organic synthesis and has a wide range of biological activities, including antibacterial, antifungal, and anti-inflammatory properties. It is also an important intermediate in the synthesis of various pharmaceuticals, such as the anti-anxiety drug fluoxetine (Prozac). 3-phenylindole has been extensively studied for its potential therapeutic applications. For instance, its derivatives have been shown to exhibit promising activity against various types of cancer cells. The compound's ability to interact with various biological targets, such as enzymes and receptors, makes it an attractive target for drug discovery. Research into 3-phenylindole focuses on its synthesis, modification, and biological evaluation to uncover its potential as a therapeutic agent in a variety of diseases.'

Cross-References

ID SourceID
PubMed CID96502
CHEMBL ID394896
SCHEMBL ID84056
MeSH IDM0112678

Synonyms (23)

Synonym
inchi=1/c14h11n/c1-2-6-11(7-3-1)13-10-15-14-9-5-4-8-12(13)14/h1-10,15
nsc76690
1504-16-1
nsc-76690
3-phenylindole
CHEMBL394896
3-phenyl-1h-indole
1h-indole, 3-phenyl-
unii-7676cpk41g
7676cpk41g ,
nsc 76690
SCHEMBL84056
3-phenyl indole
3-phenyl-1h-indole #
DTXSID80164538
AKOS027427699
DS-18933
mfcd00033474
Y13578
Q27266468
A901103
BAA50416
CS-0186850
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID300480Metabolic stability assessed as half life in Sclerotina sclerotiorum at 0.10 mM2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID300484Inhibition of Sclerotina sclerotiorums brassinin glucosyl transferase assessed as specific activity at 0.30 mM2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID300486Inhibition of Sclerotina sclerotiorums brassinin glucosyl transferase assessed as percent relative activity in relative to brassinin at 0.30 mM2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID300477Antifungal activity against Sclerotina sclerotiorum assessed as growth inhibition at 0.10 mM after 48 hrs2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID448588Antimicrobial activity against Escherichia coli ATCC 8739 after 6 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.
AID300487Inhibition of Sclerotina sclerotiorums brassinin glucosyl transferase assessed as percent relative activity in relative to brassinin at 0.60 mM2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID1091686Inhibition of Leptosphaeria maculans brassinin oxidase assessed as relative specific activity at 0.50 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID448590Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.
AID1091685Inhibition of Leptosphaeria maculans brassinin oxidase assessed as relative protein at 0.10 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID448586Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 6 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.
AID1091688Inhibition of Leptosphaeria maculans brassinin oxidase assessed as relative specific activity at 0.10 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID300478Antifungal activity against Sclerotina sclerotiorum assessed as growth inhibition at 0.05 mM after 48 hrs2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID1091689Inhibition of Leptosphaeria maculans brassinin oxidase activity at 0.10 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID448591Antimicrobial activity against Cryptococcus neoformans ATCC 90112 after 24 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.
AID1091687Inhibition of Leptosphaeria maculans brassinin oxidase assessed as relative specific activity at 0.20 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID448587Antimicrobial activity against Bacillus cereus ATCC 11778 after 6 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.
AID1091684Inhibition of Leptosphaeria maculans brassinin oxidase assessed as relative protein at 0.20 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID1091678Inhibition of Leptosphaeria maculans brassinin oxidase activity at 0.30 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID448589Antimicrobial activity against Klebsiella pneumoniae ATCC 13831 after 6 hrs2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.
AID300485Inhibition of Sclerotina sclerotiorums brassinin glucosyl transferase assessed as specific activity at 0.60 mM2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
AID1091682Antifungal activity against Leptosphaeria maculans assessed as inhibition of mycelial growth at 0.10 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID1091683Inhibition of Leptosphaeria maculans brassinin oxidase assessed as relative protein at 0.50 mM relative to control2009Journal of agricultural and food chemistry, Mar-25, Volume: 57, Issue:6
Synthetic inhibitors of the fungal detoxifying enzyme brassinin oxidase based on the phytoalexin camalexin scaffold.
AID300488Antifungal activity against Sclerotina sclerotiorum assessed as growth inhibition at 0.01 mM after 48 hrs2007Bioorganic & medicinal chemistry, Sep-01, Volume: 15, Issue:17
Design, synthesis, and evaluation of potential inhibitors of brassinin glucosyltransferase, a phytoalexin detoxifying enzyme from Sclerotinia sclerotiorum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.64 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]