3-methylitaconate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

3-methylitaconate: RN refers to (S)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6438940
CHEMBL ID	4761396
SCHEMBL ID	6365923
MeSH ID	M0139839

Synonyms (8)

Synonym
3-methylitaconate
AKOS006374421
(2e)-2-ethylidenebutanedioic acid
102714-66-9
SCHEMBL6365923
CHEMBL4761396
DTXSID201347631
(e)-ethylidenesuccinic acid

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1685613	Covalent inhibition of wild type N-terminal polyhis-tagged TEV protease cleavage site fused Mycobacterium tuberculosis ICL1 expressed in Escherichia coli BL21 (DE3) using DL-isocitrate as substrate measured after 1 hr by UV-Vis spectrophotometric analysis	2021	RSC medicinal chemistry, Jan-01, Volume: 12, Issue:1	Itaconate is a covalent inhibitor of the
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (20.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
itaconic acid itaconic acid : A dicarboxylic acid that is methacrylic acid in which one of the methyl hydrogens is substituted by a carboxylic acid group.	2.31	1	dicarboxylic acid; dicarboxylic fatty acid; olefinic compound	fungal metabolite; human metabolite
succinic acid Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.	1.96	1	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent
dimethyl itaconate dimethyl itaconate: structure in first source	2.31	1
alpha-methylene glutarate 2-methylenepentanedioic acid: structure in first source. 2-methylideneglutaric acid : A dicarboxylic acid comprising a glutaric acid core with a methylene group at the 2-position.	2.69	3	dicarboxylic acid; dicarboxylic fatty acid
aconitic acid trans-aconitic acid : The trans-isomer of aconitic acid.	2.31	1	aconitic acid	fundamental metabolite
aconitic acid cis-aconitic acid : The cis-isomer of aconitic acid.	2.31	1	aconitic acid	fundamental metabolite
cobamamide cobamamide : A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.	2.91	4

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