Compounds > 3-hydroxybromazepam
Page last updated: 2024-12-08

3-hydroxybromazepam

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-hydroxybromazepam: bromazepam metabolite; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID166774
SCHEMBL ID13585027
MeSH IDM0124512

Synonyms (19)

Synonym
bromazepam-3-hydroxy
7-bromo-3-hydroxy-5-(2-pyridinyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one
3-hydroxybromazepam
2h-1,4-benzodiazepin-2-one, 7-bromo-1,3-dihydro-3-hydroxy-5-(2-pyridinyl)-
3-hydroxy bromazepam
7-bromo-1,3-dihydro-3-hydroxy-5-(2-pyridinyl)-2h-1,4-benzodiazepin-2-one
13132-73-5
7-bromo-3-hydroxy-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one
56d3142v5y ,
unii-56d3142v5y
SCHEMBL13585027
URRUSNGCYBXNLO-UHFFFAOYSA-N
AKOS030241408
7-bromo-1,3-dihydro-3-hydroxy-5-(2-pyridyl)-2h-1,4-benzodiazepin-2-one
DTXSID80927160
7-bromo-5-(pyridin-2-yl)-3h-1,4-benzodiazepine-2,3-diol
Q21028623
3-hydroxybromazepam, 1mg/ml in acetonitrile
2h-1,4-benzodiazepin-2-one, 7-bromo-1,3-dihydro-3-hydroxy-5-(2-pyridinyl)-; 2h-1,4-benzodiazepin-2-one, 7-bromo-1,3-dihydro-3-hydroxy-5-(2-pyridyl)- (8ci); 3-hydroxybromazepam; oh-bromazepam

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Antipyrine pharmacokinetics were studied immediately before bromazepam administration was started, after the dosing schedule had been completed and one week after dosing had been discontinued."( The effect of bromazepam (Lexotan) administration on antipyrine pharmacokinetics in humans.
Allen, JG; Bird, HA; Ehsanullah, RS; Galloway, DB; Ruane, RJ, 1984)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (3)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.34

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.34 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.34)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
antipyrine
Antipyrine: An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29). antipyrine : A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at N-1 and C-5 and with a phenyl group at N-2.		1.9610pyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
bromazepam
Bromazepam: One of the BENZODIAZEPINES that is used in the treatment of ANXIETY DISORDERS.		2.6730organic molecular entity
clonazepam
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.. clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.		2.02101,4-benzodiazepinone;
monochlorobenzenes		anticonvulsant;
anxiolytic drug;
GABA modulator
7-aminoclonazepam
[no description available]		2.0210benzodiazepine
ConditionIndicatedRelationship StrengthStudiesTrials