Page last updated: 2024-12-08
3-hydroxy-5-androstane-17-carbonitrile
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
3-hydroxy-5-androstane-17-carbonitrile: RN refers to (3alpha,5alpha,17beta)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 171084 |
| CHEMBL ID | 42983 |
| SCHEMBL ID | 3120887 |
| MeSH ID | M0224945 |
Synonyms (13)
| Synonym |
|---|
| 3-ohacn |
| CHEMBL42983 |
| androstane-17-carbonitrile, 3-hydroxy-, (3alpha,5alpha,17beta)- |
| 3-hydroxy-5-androstane-17-carbonitrile |
| 51872-53-8 |
| SCHEMBL3120887 |
| 17beta-cyano-3alpha-hydroxy- 5alpha-androstane |
| DVTDUTYENPZLFP-YBXIWKLVSA-N |
| (3alpha,5alpha,17beta)-3-hydroxyandrostane-17-carbonitrile |
| E71944 |
| (3r,5s,8r,9s,10s,13s,14s,17s)-3-hydroxy-10,13-dimethylhexadecahydro-1h-cyclopenta[a]phenanthrene-17-carbonitrile |
| 3-hydroxyandrostane-17-carbonitrile |
| DTXSID70966205 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (13)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID266555 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 0.1 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID266558 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of GABA at 10 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID266557 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 10 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID197261 | Compound was evaluated at 10 uM for its ability to initiate (gate) a current in the absence of GABA in cultured postnatal rat hippocampal neurons | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21 | Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors. |
| AID197264 | Compound was evaluated at 10 uM GABA-mediated current in cultured postnatal rat hippocampal neurons | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21 | Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors. |
| AID193612 | Ability of compound at 10 uM for current activation in the absence of GABA in cultured postnatal rat hippocampal neurons using whole-cell patch clamp method | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24 | Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles. |
| AID266554 | Displacement of [35S]TBPS from GABA-A receptor in rat brain membrane | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID188186 | Effect on the potentiation of muscimol-stimulated 36Cl- uptake in rat brain synaptoneurosomes | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6 | Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. |
| AID266559 | Loss of righting reflex in Xenopus laevis tadpole | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID266560 | Loss of swimming reflex in Xenopus laevis tadpole | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID190578 | Ability of compound at 1 uM to potentiate GABA-mediated currents in cultured postnatal rat hippocampal neurons using whole-cell patch clamp method | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24 | Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles. |
| AID266556 | Activity at rat GABA-Aalpha1 receptor plus beta2gamma2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 1 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15 | Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
| AID193614 | Ability of compound at 1 uM for current activation in the absence of GABA in cultured postnatal rat hippocampal neurons using whole-cell patch clamp method | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24 | Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (14)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.09
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.09) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||