Assay ID | Title | Year | Journal | Article |
AID266555 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 0.1 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266558 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of GABA at 10 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266557 | Activity at rat GABA-Aalpha1 receptor plus beta-2-gamma-2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 10 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID197261 | Compound was evaluated at 10 uM for its ability to initiate (gate) a current in the absence of GABA in cultured postnatal rat hippocampal neurons | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors. |
AID197264 | Compound was evaluated at 10 uM GABA-mediated current in cultured postnatal rat hippocampal neurons | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors. |
AID193612 | Ability of compound at 10 uM for current activation in the absence of GABA in cultured postnatal rat hippocampal neurons using whole-cell patch clamp method | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24
| Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles. |
AID266554 | Displacement of [35S]TBPS from GABA-A receptor in rat brain membrane | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID188186 | Effect on the potentiation of muscimol-stimulated 36Cl- uptake in rat brain synaptoneurosomes | 1990 | Journal of medicinal chemistry, Jun, Volume: 33, Issue:6
| Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes. |
AID266559 | Loss of righting reflex in Xenopus laevis tadpole | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID266560 | Loss of swimming reflex in Xenopus laevis tadpole | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID190578 | Ability of compound at 1 uM to potentiate GABA-mediated currents in cultured postnatal rat hippocampal neurons using whole-cell patch clamp method | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24
| Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles. |
AID266556 | Activity at rat GABA-Aalpha1 receptor plus beta2gamma2L expressed in Xenopus laevis oocyte assessed as ratio of GABA-mediated current in presence to absence of compound at 1 uM | 2006 | Journal of medicinal chemistry, Jul-27, Volume: 49, Issue:15
| Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. |
AID193614 | Ability of compound at 1 uM for current activation in the absence of GABA in cultured postnatal rat hippocampal neurons using whole-cell patch clamp method | 1993 | Journal of medicinal chemistry, Nov-26, Volume: 36, Issue:24
| Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |