Compounds > 3-hydroxy-2,2-diphenylpropanoic acid
Page last updated: 2024-09-24

3-hydroxy-2,2-diphenylpropanoic acid

Cross-References

ID SourceID
PubMed CID78192
CHEMBL ID1889262
CHEBI ID109767
SCHEMBL ID6384616

Synonyms (23)

Synonym
3-hydroxy-2,2-diphenyl-propionic acid
2xn606z8di ,
unii-2xn606z8di
3-hydroxy-2,2-diphenylpropionic acid
nsc 16302
einecs 224-689-4
4448-72-0
nsc16302
nsc-16302
MLS001075457
smr000639476
CHEBI:109767
3-hydroxy-2,2-diphenylpropanoic acid
NCGC00247444-01
HMS2193P05
HMS3343J10
SCHEMBL6384616
CHEMBL1889262
Q27189052
DTXSID70196186
.alpha.-(hydroxymethyl)-.alpha.-phenylbenzeneacetic acid
.alpha.-phenyltropic acid
benzeneacetic acid, .alpha.-(hydroxymethyl)-.alpha.-phenyl-

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency23.77810.003245.467312,589.2998AID2517
WRNHomo sapiens (human)Potency3.16230.168331.2583100.0000AID651768
USP1 protein, partialHomo sapiens (human)Potency0.28180.031637.5844354.8130AID743255
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency26.67950.168316.404067.0158AID720504
Guanine nucleotide-binding protein GHomo sapiens (human)Potency5.62341.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
b 844-39[no description available]low00diarylmethane
3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane[no description available]low00diarylmethane
adiphenine[no description available]low00diarylmethane
3-(2'-aminobenzhydryloxy)tropane[no description available]low00diarylmethane
2,2-bis(4-glycidyloxyphenyl)propane[no description available]low00diarylmethane
benproperine[no description available]low00diarylmethane
cogentin[no description available]low00diarylmethane
bifemelane[no description available]low00diarylmethane
bisacodyl[no description available]low00diarylmethane
chlorcyclizine[no description available]low00diarylmethane
cifenline[no description available]low00diarylmethane
clidinium[no description available]low00diarylmethane
clofedanol[no description available]low00diarylmethane;
tertiary amino compound		antitussive
clofoctol[no description available]low00diarylmethane
cloperastine[no description available]low00diarylmethane
r 59022[no description available]low00diarylmethane
dichlorophen[no description available]low00bridged diphenyl fungicide;
diarylmethane
fendiline[no description available]low00diarylmethane
1-[bis(4-fluorophenyl)methyl]-4-(3-phenylprop-2-enyl)piperazine[no description available]low00diarylmethane
fluspirilene[no description available]low00diarylmethane
homochlorocyclizine[no description available]low00diarylmethane
isopropamide iodide[no description available]low00diarylmethane
lidoflazine[no description available]low00diarylmethane
lomerizine[no description available]low00diarylmethane
manidipine[no description available]low00diarylmethane
meclizine[no description available]low00diarylmethane
mepenzolate[no description available]low00diarylmethane
methadone[no description available]low00benzenes;
diarylmethane;
ketone;
tertiary amino compound
mitotane[no description available]low00diarylmethane
no 711[no description available]low00diarylmethane
oxatomide[no description available]low00benzimidazoles;
diarylmethane;
N-alkylpiperazine		anti-allergic agent;
anti-inflammatory agent;
geroprotector;
H1-receptor antagonist;
serotonergic antagonist
pipenzolate[no description available]low00diarylmethane
piperidolate[no description available]low00diarylmethane
proadifen[no description available]low00diarylmethane
propiverine[no description available]low00diarylmethane
aurin[no description available]low00diarylmethane
dpi 201-106[no description available]low00diarylmethane
terfenadine[no description available]low00diarylmethane
mepenzolate bromide[no description available]low00diarylmethane
chlorphenoxamine[no description available]low00diarylmethaneanticoronaviral agent
chlorfenethol[no description available]low00diarylmethane
diphenadione[no description available]low00beta-triketone;
diarylmethane
phenyltoloxamine[no description available]low00diarylmethane
n,n,n',n'-tetramethyl-4,4'-methylenedianiline[no description available]low00diarylmethane
diphenan[no description available]low00diarylmethane
diphenylmethane[no description available]low00diarylmethane
2,2'-methylenebis(4-methyl-6-tert-butylphenol)[no description available]low00diarylmethane
piperidolate hydrochloride[no description available]low00diarylmethane
benactyzine[no description available]low00diarylmethane
prenylamine[no description available]low00diarylmethane
isomethadone[no description available]low00diarylmethane
pipradrol[no description available]low00diarylmethane
normethadone[no description available]low00diarylmethane
captodiamine[no description available]low00diarylmethane
methadyl acetate[no description available]low00diarylmethane
benzomethamine[no description available]low00diarylmethane
chlorobenzilate[no description available]low00diarylmethane
dimenhydrinate[no description available]low00diarylmethane
poldine[no description available]low00diarylmethane
thiphenamil[no description available]low00diarylmethane
4-cumylphenol[no description available]low00diarylmethane
4,4'-bisphenol f[no description available]low00bisphenol;
diarylmethane		environmental food contaminant;
xenoestrogen
o,p'-ddt[no description available]low00diarylmethane
4,4'-methylene bis(2-methylaniline)[no description available]low00diarylmethane
dipipanone[no description available]low00diarylmethane
diphenamid[no description available]low00diarylmethane
paracymethadol[no description available]low00diarylmethane
bisphenol a-glycidyl methacrylate[no description available]low00diarylmethane
azacyclonol[no description available]low00diarylmethane
dimenoxadol[no description available]low00diarylmethane
amphenone b[no description available]low00diarylmethane
propinox[no description available]low00diarylmethane
embramine[no description available]low00diarylmethane
chlorophacinone[no description available]low00beta-triketone;
diarylmethane
aminopentamide[no description available]low00diarylmethane
octocrylene[no description available]low00diarylmethane
terodiline[no description available]low00diarylmethane
tofenacin[no description available]low00diarylmethane
pipoxolan[no description available]low00diarylmethane
penfluridol[no description available]low00diarylmethane
emepronium[no description available]low00diarylmethane
levomethadyl acetate hydrochloride[no description available]low00diarylmethane
flumecinol[no description available]low00diarylmethane
setastine[no description available]low00diarylmethane
progabide[no description available]low00diarylmethane
beclobrate[no description available]low00diarylmethane
cetirizine dihydrochloride[no description available]low00diarylmethane
niguldipine[no description available]low00diarylmethane
mandrax[no description available]low00diarylmethane
droprenylamine[no description available]low00diarylmethane
quifenadine[no description available]low00diarylmethane
carebastine[no description available]low00diarylmethane
lercanidipine[no description available]low00diarylmethane
diphenidol hydrochloride[no description available]low00diarylmethane
dioxadrol[no description available]low00diarylmethane
budipine[no description available]low00diarylmethane
epicainide[no description available]low00diarylmethane
butinoline[no description available]low00diarylmethane
denaverine[no description available]low00diarylmethane
lifarizine[no description available]low00diarylmethane
fenpiverinium[no description available]low00diarylmethane
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)[no description available]low00diarylmethane
amperozide[no description available]low00diarylmethane;
monofluorobenzenes;
N-alkylpiperazine;
secondary carboxamide;
ureas		anxiolytic drug;
dopamine uptake inhibitor;
geroprotector;
second generation antipsychotic;
serotonergic antagonist
2,2'-bisphenol f[no description available]low00diarylmethane
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene[no description available]low00diarylmethane
bisphenol f diglycidyl ether[no description available]low00aromatic ether;
diarylmethane;
epoxide
n-(4,4-diphenyl-3-butenyl)nipecotic acid[no description available]low00diarylmethane
methylene bis(methylanthranilate)[no description available]low00diarylmethane
tesmilifene[no description available]low00diarylmethane
pd 123177[no description available]low00diarylmethane
bw 373u86[no description available]low00diarylmethane
gilutensin hydrochloride[no description available]low00diarylmethane
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide[no description available]low00diarylmethane
ae0047[no description available]low00diarylmethane
lercanidipine hydrochloride[no description available]low00diarylmethane
cloperastine hydrochloride[no description available]low00diarylmethane
1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane[no description available]low00diarylmethane
2-[(4,6-dimethyl-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid[no description available]low00diarylmethane
ci 966[no description available]low00diarylmethane
Difeterol[no description available]low00diarylmethane
1,1-bis(4-hydroxyphenyl)cyclohexane[no description available]low00diarylmethane
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene[no description available]low00diarylmethane
N-[2-(dimethylamino)ethyl]-2,2-diphenylacetamide[no description available]low00diarylmethane
propiverine hydrochloride[no description available]low00diarylmethane
gw 3965[no description available]low00diarylmethane
1,1-Bis(4-hydroxyphenyl)ethane[no description available]low00diarylmethane
uk 78282[no description available]low00diarylmethane
r 59949[no description available]low00diarylmethane
4-[1-(4-hydroxyphenyl)ethenyl]phenol[no description available]low00diarylmethane
5-[4-(diphenylmethyl)-1-piperazinyl]-2-(2-methoxyphenyl)-4-oxazolecarbonitrile[no description available]low00diarylmethane
flunarizine[no description available]low00diarylmethane
N-[4-[oxo-[(1-oxo-2,2-diphenylethyl)hydrazo]methyl]phenyl]propanamide[no description available]low00diarylmethane
[4-(diphenylmethyl)-1-piperazinyl]-[5-thiophen-2-yl-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone[no description available]low00diarylmethane
benztropine[no description available]low00diarylmethane
3-[[[(1-oxo-2,2-diphenylethyl)amino]-sulfanylidenemethyl]amino]benzoic acid[no description available]low00diarylmethane
3-bromo-5-[[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-oxomethyl]-2-pyranone[no description available]low00diarylmethane
2-(5-bromo-3-nitro-1,2,4-triazol-1-yl)-N-(diphenylmethyl)acetamide[no description available]low00diarylmethane
1,1-bis(4-chlorophenyl)-2-[(3-methoxyphenyl)methylamino]ethanol[no description available]low00diarylmethane
cinnarizine[no description available]low00diarylmethane;
N-alkylpiperazine;
olefinic compound		anti-allergic agent;
antiemetic;
calcium channel blocker;
geroprotector;
H1-receptor antagonist;
histamine antagonist;
muscarinic antagonist
levocetirizine[no description available]low00diarylmethane
amn082[no description available]low00benzenes;
diamine;
diarylmethane;
secondary amino compound		metabotropic glutamate receptor agonist;
neuroprotective agent
N-[2-[tert-butyl(methyl)amino]ethyl]-N-methyl-2,2-diphenylacetamide[no description available]low00diarylmethane
N-(4-fluorophenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide[no description available]low00diarylmethane
4-oxo-3-[(1-oxo-2,2-diphenylethyl)amino]-2-sulfanylidene-1H-quinazoline-7-carboxylic acid methyl ester[no description available]low00diarylmethane
2,2-diphenylacetic acid (2,6-dimethylphenyl) ester[no description available]low00diarylmethane
1-ethyl-3-[(1-oxo-2,2-diphenylethyl)amino]thiourea[no description available]low00diarylmethane
2-(phenylmethyl)benzoic acid [2-[4-(difluoromethylthio)anilino]-2-oxoethyl] ester[no description available]low00diarylmethane
2-[2-[bis(4-methoxyphenyl)methylidene]hydrazinyl]benzoic acid[no description available]low00diarylmethane
N-[4-bromo-2-[[(2-hydrazinyl-2-oxoethyl)amino]-phenylmethyl]phenyl]-3-(4-morpholinyl)propanamide[no description available]low00diarylmethane
N-(4-ethoxyphenyl)-4-[hydroxy(diphenyl)methyl]-1-piperidinecarbothioamide[no description available]low00diarylmethane
4-[hydroxy(diphenyl)methyl]-N-(2-phenylethyl)-1-piperidinecarbothioamide[no description available]low00diarylmethane
3-(5-chloro-2-hydroxyphenyl)-3-phenyl-N-[(4-propan-2-yloxyphenyl)methyl]propanamide[no description available]low00diarylmethane
adrafinil[no description available]low00diarylmethane
zamifenacin[no description available]low00diarylmethane
2-(cyclohexylamino)-N-[(diphenylmethylene)amino]propanamide[no description available]low00diarylmethane
3-[[4-(diphenylmethyl)-1-piperazinyl]-oxomethyl]-7,8,9,10-tetrahydro-6H-azepino[2,1-b]quinazolin-12-one[no description available]low00diarylmethane
3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane[no description available]low00diarylmethane
flunarizine hydrochloride[no description available]low00diarylmethane
(2-amino-5-chlorophenyl)(phenyl)methanone oxime[no description available]low00diarylmethane
imidafenacin[no description available]low00diarylmethane
2-(3,3-diphenylpropylamino)acetamide[no description available]low00diarylmethane
cgk 733[no description available]low00diarylmethane
dexniguldipine[no description available]low00diarylmethane
lu 208075[no description available]low00diarylmethane
fesoterodine[no description available]low00diarylmethane
3-(diphenylmethylene)-1-[4-(4-phenyl-1-piperazinyl)butyl]pyrrolidine-2,5-dione[no description available]low00diarylmethane
pnu 200577[no description available]low00diarylmethane
gc 1 compound[no description available]low00diarylmethane
tas 301[no description available]low00diarylmethane
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol[no description available]low00diarylmethane
[4-(diphenylmethyl)-1-piperazinyl]-(5-methyl-4-nitro-3-isoxazolyl)methanone[no description available]low00diarylmethane
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamine[no description available]low00diarylmethane
1-[4-(3-chlorophenyl)-1-piperazinyl]-3-(diphenylmethyl)oxy-2-propanol[no description available]low00diarylmethane
(8R)-3-[3-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]phenyl]-7-(1-oxo-3,3-diphenylpropyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide[no description available]low00diarylmethane
3-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-(3-methyl-1-piperidinyl)-1-propanone[no description available]low00diarylmethane
2-[[[4-[[(diphenylmethyl)amino]-oxomethyl]-1H-imidazol-5-yl]-oxomethyl]amino]acetic acid tert-butyl ester[no description available]low00diarylmethane;
tert-butyl ester
pf 04971729[no description available]low00diarylmethane
ML-210[no description available]low00C-nitro compound;
diarylmethane;
isoxazoles;
monochlorobenzenes;
N-acylpiperazine;
N-alkylpiperazine;
tertiary carboxamide		antineoplastic agent;
EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials
Inflammation0low10
Innate Inflammatory Response0low10