| Assay ID | Title | Year | Journal | Article |
|---|
| AID683163 | Displacement of [3H]MPEP from mGluR5 in Sprague-Dawley rat brain membrane after 60 mins by liquid scintillation counting | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683187 | Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in the centre region at 3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683164 | Ratio of MPEP Ki to compound Ki for mGluR5 in Sprague-Dawley rat brain membrane | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683186 | Anxiolytic activity in Swiss Webster mouse assessed as increase in locomotor activity at 3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683179 | Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in the centre region at 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683178 | Anxiolytic activity in Swiss Webster mouse assessed as increase in locomotor activity at 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by open-field test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683180 | Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in light compartment at 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683189 | Anxiolytic activity in Swiss Webster mouse assessed as increase in number of compartment transitions at 3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683168 | Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in time spent in light compartment administered as single dose 15 mins prior to testing by light-dark box test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683188 | Anxiolytic activity in Swiss Webster mouse assessed as increase in time spent in light compartment at 3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683165 | Inverse agonist activity at rat mGluR5 expressed in HEK293A cells coexpressing Gqalpha assessed as inhibition of quisqualic-induced D-myo-inositol 1 production by ELISA | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID601415 | Antagonist activity at rat mGluR5 expressed in human HEK-293 cells assessed as inhibition of glutamate-induced intracellular calcium mobilization | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. |
| AID683181 | Anxiolytic activity in Swiss Webster mouse assessed as increase in number of compartment transitions at 0.3 mg/kg, ip administered as single dose 15 mins prior to testing by light-dark box test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683169 | Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in number of compartment transitions administered as single dose 15 mins prior to testing by light-dark box test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683166 | Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in locomotor activity administered as single dose 15 mins prior to testing by open-field test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID683167 | Anxiolytic activity in ip dosed Swiss Webster mouse assessed as increase in time spent in the centre region administered as single dose 15 mins prior to testing by open-field test | 2012 | ACS medicinal chemistry letters, Jul-12, Volume: 3, Issue:7
| Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |