3-deacetylvecuronium

Description

3-deacetylvecuronium: RN given refers to parent cpd (2beta,3alpha,5alpha,16beta,17beta)-isomer; structure given in first source [MeSH]

3-Hydroxyvecuronium : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	11849104
CHEBI ID	187362
MeSH ID	M0138188

Synonyms (16)

Synonym
3-hydroxyvecuronium
74041-85-3
CHEBI:187362
[(2s,3s,5s,8r,9s,10s,13s,14s,16s,17r)-3-hydroxy-10,13-dimethyl-16-(1-methylpiperidin-1-ium-1-yl)-2-piperidin-1-yl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate
3-deacetylvecuronium
3-desacetylvecuronium
unii-7gjt8823h1
7gjt8823h1 ,
piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-17-(acetyloxy)-3-hydroxy-2-(1-piperidinyl)androstan-16-yl)-1-methyl-
desacetylvecuronium
piperidinium, 1-((2.beta.,3.alpha.,5.alpha.,16.beta.,17.beta.)-17-(acetyloxy)-3-hydroxy-2-(1-piperidinyl)androstan-16-yl)-1-methyl-
3-deacetylvecuronium cation
1-(17.beta.-(acetyloxy)-3.alpha.-hydroxy-2.beta.-(piperidin-1-yl)-5.alpha.-androstan-16.beta.-yl)-1-methylpiperidinium
vecuronium bromide impurity c [ep impurity]
org-7268 cation
Q27268251

Drug Classes (1)

Class	Description
steroid ester

Research

Studies (11)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (18.18)	18.7374
1990's	7 (63.64)	18.2507
2000's	1 (9.09)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (16.67%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (83.33%)	84.16%

Substance	Classes	Roles	Relationship Strength
methylprednisolone acetate	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; acetate ester; glucocorticoid; steroid ester; tertiary alpha-hydroxy ketone	anti-inflammatory drug	low
testosterone propionate	steroid ester		low
medroxyprogesterone acetate	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; corticosteroid; steroid ester	adjuvant; androgen; antineoplastic agent; antioxidant; female contraceptive drug; inhibitor; progestin; synthetic oral contraceptive	low
estradiol dipropionate	steroid ester		low
ethynodiol diacetate	steroid ester; terminal acetylenic compound	contraceptive drug; estrogen receptor modulator; synthetic oral contraceptive	low
estradiol 17 beta-cypionate	steroid ester		low
nandrolone decanoate	steroid ester		low
cyproterone acetate	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; chlorinated steroid; steroid ester	androgen antagonist; geroprotector; progestin	low
estriol succinate	hemisuccinate; steroid ester		low
megestrol acetate	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; steroid ester	antineoplastic agent; appetite enhancer; contraceptive drug; progestin; synthetic oral contraceptive	low
turinabol	steroid ester		low
estradiol valerate	steroid ester		low
stanolone benzoate	3-oxo-5alpha-steroid; steroid ester		low
dehydroepiandrosterone acetate	steroid ester		low
testosterone 17-phenylpropionate	steroid ester		low
betamethasone valerate	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; fluorinated steroid; primary alpha-hydroxy ketone; steroid ester	anti-inflammatory drug	low
estradiol enanthate	steroid ester		low
beclomethasone dipropionate	11beta-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; chlorinated steroid; corticosteroid; enone; glucocorticoid; propanoate ester; steroid ester	anti-arrhythmia drug; anti-asthmatic drug; anti-inflammatory drug; prodrug	low
betamethasone-17,21-dipropionate	11beta-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; fluorinated steroid; propanoate ester; steroid ester	antipsoriatic	low
pipecuronium	steroid ester		low
testosterone undecanoate	steroid ester		low
trenbolone acetate	steroid ester		low
nisone	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; acetate ester; steroid ester; tertiary alpha-hydroxy ketone		low
dehydropregnenolone acetate	steroid ester		low
19-norandrostenolone 17-cyclohexylpropionate	steroid ester		low
Estriol tripropionate	steroid ester		low
nandrolone furylpropionate	steroid ester		low
ulipristal acetate	20-oxo steroid; 3-oxo-Delta(4) steroid; acetate ester; steroid ester; tertiary amino compound	contraceptive drug; progesterone receptor modulator; progestin	low
androstane-3,17-diol dipropionate	steroid ester		low
testosterone decanoate	steroid ester		low
dromostanolone propionate	3-oxo-5alpha-steroid; steroid ester	antineoplastic agent	low
norethindrone enanthate	steroid ester		low
testosterone isocaproate	steroid ester		low
methenolone enanthate	steroid ester		low
methenolone acetate	steroid ester		low
pancuronium	acetate ester; steroid ester	cholinergic antagonist; muscle relaxant; nicotinic antagonist	low
mometasone furoate	11beta-hydroxy steroid; 2-furoate ester; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; organochlorine compound; steroid ester	anti-allergic agent; anti-inflammatory drug	low
betamethasone acetate	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; acetate ester; fluorinated steroid; steroid ester; tertiary alpha-hydroxy ketone		low
loteprednol etabonate	11beta-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; etabonate ester; organochlorine compound; steroid acid ester; steroid ester	anti-inflammatory drug	low
fluticasone propionate	11beta-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; corticosteroid; fluorinated steroid; propanoate ester; steroid ester; thioester	adrenergic agent; anti-allergic agent; anti-asthmatic drug; anti-inflammatory drug; bronchodilator agent; dermatologic drug	low
acetic acid (3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl) ester	steroid ester		low
sch 22219	11beta-hydroxy steroid; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; chlorinated steroid; glucocorticoid; propanoate ester; steroid ester	anti-inflammatory drug	low
Pregnenolone acetate	steroid ester		low
androstane-3,17-diol glucuronide	steroid ester		low
progesterone 11-hemisuccinate, (11alpha)-isomer	20-oxo steroid; 3-oxo-Delta(4) steroid; dicarboxylic acid monoester; hemisuccinate; steroid ester		low
rapacuronium	steroid ester		low
[(10R,13S,17R)-17-Ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate	steroid ester		low
norgestimate	ketoxime; steroid ester; terminal acetylenic compound	contraceptive drug; progestin; synthetic oral contraceptive	low
estradiol 17-acetate	steroid ester		low
oleandrigenin	14beta-hydroxy steroid; 3beta-hydroxy steroid; steroid ester	EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; metabolite	low
telapristone acetate	steroid ester		low
estradiol-3,17-diacetate	steroid ester		low
fluticasone furoate	11beta-hydroxy steroid; 2-furoate ester; 3-oxo-Delta(1),Delta(4)-steroid; corticosteroid; fluorinated steroid; steroid ester; thioester	anti-allergic agent; anti-asthmatic drug; prodrug	low
etiprednol dicloacetate	steroid ester		low
oleandrin	14beta-hydroxy steroid; cardenolide glycoside; steroid ester; steroid saponin		low
campesteryl ferulate	steroid ester		low
Resocortol butyrate	steroid ester		low
physapubescin	steroid ester		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's
nitrous oxide	1	gas molecular entity; nitrogen oxide	analgesic; bacterial metabolite; food packaging gas; food propellant; general anaesthetic; greenhouse gas; inhalation anaesthetic; NMDA receptor antagonist; raising agent; refrigerant; vasodilator agent	1996	1996	28.0	low	1	0	1	0	0
phenytoin	1	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent	2004	2004	20.0	low	0	0	0	1	0
hexamethonium	1	quaternary ammonium salt		1985	1985	39.0	low	0	1	0	0	0
isoflurane	1	organofluorine compound	inhalation anaesthetic	1996	1996	28.0	low	1	0	1	0	0
neostigmine	1	quaternary ammonium ion	antidote to curare poisoning; EC 3.1.1.7 (acetylcholinesterase) inhibitor	1985	1985	39.0	low	0	1	0	0	0
sevoflurane	1	ether; organofluorine compound	central nervous system depressant; inhalation anaesthetic; platelet aggregation inhibitor	1996	1996	28.0	low	1	0	1	0	0
galactosamine	1	D-galactosamine; primary amino compound	toxin	1991	1991	33.0	low	0	0	1	0	0
androstane-3,17-diol	1	17-hydroxy steroid; 3-hydroxy steroid; androstanoid		1988	1988	36.0	low	0	1	0	0	0
vecuronium bromide	11	organic bromide salt; quaternary ammonium salt	muscle relaxant; neuromuscular agent; nicotinic antagonist	1985	2011	29.1	high	2	2	7	1	1
pipecuronium	1	steroid ester		1988	1988	36.0	low	0	1	0	0	0
pancuronium	3	acetate ester; steroid ester	cholinergic antagonist; muscle relaxant; nicotinic antagonist	1985	1992	35.7	medium	0	2	1	0	0
thiopental	1	barbiturates	anticonvulsant; drug allergen; environmental contaminant; intravenous anaesthetic; sedative; xenobiotic	1996	1996	28.0	low	1	0	1	0	0
rapacuronium	1	steroid ester		1999	1999	25.0	low	0	0	1	0	0
org 6368	1			1992	1992	32.0	medium	0	0	1	0	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	1990's	2000's
Acute Liver Injury, Drug-Induced	1	1991	1991	33.0	medium	0	1	0
Benign Supratentorial Neoplasms	1	2004	2004	20.0	medium	0	0	1
Chemical and Drug Induced Liver Injury	1	1991	1991	33.0	medium	0	1	0
ENT Diseases	1	1996	1996	28.0	medium	1	1	0
Kidney Diseases	1	1991	1991	33.0	medium	0	1	0
Liver Diseases	1	1991	1991	33.0	medium	0	1	0
Liver Dysfunction	1	1991	1991	33.0	medium	0	1	0
Muscle Contraction	1	1992	1992	32.0	medium	0	1	0

Long-term Use (2)

Article	Year
The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers. The Journal of pharmacology and experimental therapeutics, , Volume: 270, Issue:3	1994
Antagonism of vecuronium by one of its metabolites in vitro. European journal of pharmacology, , Nov-03, Volume: 222, Issue:1	1992

Pharmacokinetics (5)

Article	Year
Influence of chronic phenytoin administration on the pharmacokinetics and pharmacodynamics of vecuronium. Anesthesiology, , Volume: 100, Issue:3	2004
Pharmacokinetics and pharmacokinetic-dynamic relationship between rapacuronium (Org 9487) and its 3-desacetyl metabolite (Org 9488). Anesthesia and analgesia, , Volume: 88, Issue:3	1999
The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers. The Journal of pharmacology and experimental therapeutics, , Volume: 270, Issue:3	1994
Pharmacokinetics, neuromuscular effects, and biodisposition of 3-desacetylvecuronium (Org 7268) in cats. Anesthesiology, , Volume: 74, Issue:6	1991
Pharmacokinetics of steroidal muscle relaxants in isolated perfused rat liver. Biochemical pharmacology, , Oct-06, Volume: 44, Issue:7	1992

Dosage (1)

Article	Year
Antagonism of vecuronium by one of its metabolites in vitro. European journal of pharmacology, , Nov-03, Volume: 222, Issue:1	1992

3-deacetylvecuronium

Description

Cross-References

Synonyms (16)

Drug Classes (1)

Research

Studies (11)

Study Types

Related Drugs (69)

Drugs in this Class (58)

Drugs Researched Together (14)

Related Conditions (8)

Long-term Use (2)

Pharmacokinetics (5)

Dosage (1)