3-Chloromandelic acid is a synthetic organic compound with a chlorine atom substituted at the 3-position of the mandelic acid molecule. It has been investigated for its potential as a precursor to pharmaceuticals and as a chiral building block in organic synthesis. The compound is synthesized through various methods, including the chlorination of mandelic acid or the reduction of 3-chlorobenzoyl chloride. Research on 3-chloromandelic acid is driven by its potential pharmacological applications, especially in the development of anti-inflammatory agents, anti-cancer drugs, and inhibitors of certain enzymes. The compound has shown inhibitory activity against specific enzymes, including trypsin and chymotrypsin, which are involved in various physiological processes.'
| ID Source | ID |
|---|---|
| PubMed CID | 85981 |
| SCHEMBL ID | 606570 |
| MeSH ID | M0551972 |
| Synonym |
|---|
| AC-19770 |
| nsc126599 |
| 16273-37-3 |
| nsc-126599 |
| OPREA1_095112 |
| IDI1_012092 |
| MAYBRIDGE3_000705 |
| 3-chlorophenylglycolic acid |
| 3-chloro-dl-mandelic acid |
| C2009 |
| 2-(3-chlorophenyl)-2-hydroxyacetic acid |
| HMS1433A01 |
| FT-0690337 |
| A810411 |
| 3-chloromandelic acid |
| AKOS005265356 |
| nsc 126599 |
| einecs 240-376-5 |
| FT-0637348 |
| SCHEMBL606570 |
| SAMVPMGKGGLIPF-UHFFFAOYSA-N |
| 3-chloro-alpha-hydroxybenzeneacetic acid |
| racemic 3-chloromandelic acid |
| mfcd04038807 |
| mfcd00829409 |
| CS-B1390 |
| FT-0773195 |
| (+/-)-m-chloromandelic acid; 2-(3-chlorophenyl)-2-(hydroxy)acetic aci |
| (alphar)-3-chloro-alpha-hydroxybenzeneacetic acid; (r)-(-)-3-chloromandelic acid; (r)-(3-chlorophenyl)hydroxyacetic acid |
| benzeneacetic acid, 3-chloro-alpha-hydroxy- |
| SY239962 |
| SB45014 |
| DTXSID801314787 |
| ()-m-chloromandelic acid; 2-(3-chlorophenyl)-2-(hydroxy)acetic aci |
| EN300-146320 |
| SY049435 |
| AS-80458 |
| 3-chloro mandelic acid |
| Z788000712 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.13) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||