Compounds > 3-aminopyrazine-2-carboxylic acid
Page last updated: 2024-12-06

3-aminopyrazine-2-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

3-Aminopyrazine-2-carboxylic acid is a heterocyclic compound that has been investigated for its potential as a building block for pharmaceuticals and agrochemicals. It is a valuable precursor for the synthesis of various bioactive compounds, including anticancer agents, anti-inflammatory agents, and herbicides. The compound's synthesis typically involves the reaction of 2-aminopyrazine with carbon dioxide under high pressure and temperature. Research on 3-aminopyrazine-2-carboxylic acid is driven by its potential to act as a scaffold for developing new drugs with improved efficacy and selectivity. Its unique structure and the presence of amine and carboxylic acid functionalities offer opportunities for modification and functionalization, enabling the design of compounds with diverse biological activities. The compound's ability to bind to various enzymes and receptors has been of particular interest, suggesting its potential in modulating biological processes. Ongoing research explores its therapeutic applications in various disease areas, including cancer, inflammation, and neurological disorders. The compound's physicochemical properties, such as its solubility and stability, are also being investigated for its potential as a lead compound in drug development.'

Cross-References

ID SourceID
PubMed CID72656
CHEMBL ID5205921
SCHEMBL ID65106
MeSH IDM0066086

Synonyms (55)

Synonym
HMS1786J07
AC-1268
nsc-225114
AB-323/25048525
nsc13148
5424-01-1
nsc-13148
nsc225114
nsc135056
3-aminopyrazine-2-carboxylic acid
59698-27-0
3-amino-2-carboxypyrazine
OPREA1_107188
3-amino-2-pyrazinecarboxylic acid, >=99%
A0848
3-amino-2-pyrazinecarboxylic acid
AKOS000121386
3-aminopiperazine-2-carboxylic acid
STK525001
x78b5d12fn ,
unii-x78b5d12fn
nsc 13148
einecs 226-558-7
pyrazinecarboxylic acid, 3-amino-
ai3-61137
ec 226-558-7
nsc 225114
2-amino-3-carboxypyrazine
3-aminopyrazinecarboxylic acid
FT-0615066
FT-0614898
AM20070435
AB00606
SCHEMBL65106
MS-0291
SY005247
mfcd00006141
2-amino-3-pyrazinecarboxylic acid
3-amino-pyrazine-2-carboxylic acid
3-aminopyrazine carboxylic acid
2-aminopyrazine-3-carboxylic acid
2-pyrazinecarboxylic acid, 3-amino-
W-105651
STR04136
CS-W020071
DTXSID20202589
F8880-4479
CHEMBL5205921
Z56818526
3-amino-2-pyrazinoic acid
pyrazinoic acid, 3-amino-
3-aminopyrazine-2-carboxylicacid
EN300-16898
deacetylhypnosin
HY-Y1702
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1848089Binding affinity to Mycobacterium tuberculosis PanD assessed as dissociation constant by isothermal titration calorimetry2022Bioorganic & medicinal chemistry, 11-15, Volume: 74Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
AID1848087Cytotoxicity against African green monkey Vero cells assessed as cell viability at 1.5 mM incubated for 24 hrs by XTT assay2022Bioorganic & medicinal chemistry, 11-15, Volume: 74Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
AID1848088Antimycobacterial activity against POA-resistant Mycobacterium bovis BCG harboring PanD Leu132Arg mutant assessed as inhibition of bacterial growth incubated for 5 days by broth microdilution method2022Bioorganic & medicinal chemistry, 11-15, Volume: 74Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
AID1848086Antimycobacterial activity against Mycobacterium bovis BCG Pasteur ATCC35734 assessed as inhibition of bacterial growth incubated for 5 days by broth microdilution method2022Bioorganic & medicinal chemistry, 11-15, Volume: 74Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
AID1848091Binding affinity to Mycobacterium tuberculosis PanD assessed as change in entropy by isothermal titration calorimetry2022Bioorganic & medicinal chemistry, 11-15, Volume: 74Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
AID1848090Binding affinity to Mycobacterium tuberculosis PanD assessed as change in enthalpy by isothermal titration calorimetry2022Bioorganic & medicinal chemistry, 11-15, Volume: 74Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's0 (0.00)29.6817
2010's3 (42.86)24.3611
2020's2 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.19 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.97 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzoic acid
Benzoic Acid: A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid.. benzoic acid : A compound comprising a benzene ring core carrying a carboxylic acid substituent.. aromatic carboxylic acid : Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.		2.4110benzoic acidsalgal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		2.4110pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
picolinic acid
picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206. picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.		2.4110pyridinemonocarboxylic acidhuman metabolite;
MALDI matrix material
pyrazinoic acid
pyrazinoic acid: active metabolite of pyrazinamide; structure. pyrazine-2-carboxylic acid : The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.		2.4110pyrazinecarboxylic acidantitubercular agent;
drug metabolite
isonicotinic acid
isonicotinic acid : A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring.		2.4110pyridinemonocarboxylic acidalgal metabolite;
human metabolite
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		2.9240diazine;
pyrazines		Daphnia magna metabolite
argon
Argon: A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.		7.3110monoatomic argon;
noble gas atom;
p-block element atom		food packaging gas;
neuroprotective agent
quinoxaline-2-carboxylic acid
[no description available]		2.4110
5-hydroxypyrazinoic acid
5-hydroxypyrazinoic acid: metabolite of pyrazinamide		2.4110
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610
Koch's Disease
[description not available]		02.4110
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.4110