Compounds > 3-amino-1-propanol
Page last updated: 2024-12-05

3-amino-1-propanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-Amino-1-propanol (3-AP) is a primary amino alcohol with the formula H2NCH2CH2CH2OH. It is a colorless liquid with a faint ammonia-like odor. 3-AP is a versatile chemical building block used in the synthesis of various pharmaceuticals, agrochemicals, and other industrial chemicals. Its importance lies in its ability to act as a precursor for various amine-containing compounds and its potential applications in various fields. 3-AP can be synthesized through several methods, including the reduction of 3-cyanopropanol and the reaction of 3-chloropropanol with ammonia. Studies on 3-AP focus on its potential applications in pharmaceuticals, such as its use as an intermediate in the synthesis of anticonvulsant drugs and its ability to act as a neurotransmitter. 3-AP has also been studied for its use in the synthesis of biocompatible materials and its potential application in green chemistry.'

3-aminopropan-1-ol : A member of the class of propanolamines that is propane with a hydroxy substituent at C-1 and an amino substituent at C-2, making it both a primary amine and a primary alcohol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID9086
CHEMBL ID115530
CHEBI ID143408
MeSH IDM0284268

Synonyms (85)

Synonym
3-aminopropyl alcohol
1-amino-3-hydroxypropane
1-propanol, 3-amino-
nsc-7766
3-hydroxypropylamine
.gamma.-aminopropanol
3-amino-1-propanol
156-87-6
1-amino-3-propanol
nsc7766
3-aminopropanol
wln: z3q
3-propanolamine
.beta.-alaninol
propanolamine
gamma-hydroxy-1-propylamine
beta-alaninol
1,3-propanolamine
ai3-25439
hsdb 5161
nsc 7766
einecs 205-864-4
brn 0741855
gamma-aminopropanol
n-propanolamine
3-hydroxy-1-propylamine
inchi=1/c3h9no/c4-2-1-3-5/h5h,1-4h
3-aminopropan-1-ol
3-amino-1-propanol, 99%
3-amino-1-propanol, >=99%
A0438
CHEMBL115530
FT-0654141
CHEBI:143408
3-hydroxypropan-1-amine
3-hydroxy-1-aminopropane
AKOS000119899
3-amino-propan-1-ol
ec 205-864-4
unii-yma7c44xgy
yma7c44xgy ,
FT-0614913
.gamma.-hydroxy-1-propylamine
n-(3-hydroxypropyl)amine
propanolamine [hsdb]
propanolamine [usp-rs]
dexpanthenol impurity a [ep impurity]
3-amino-propanol
1-amino-3-propyl alcohol
3-hydroxy-propyl amine
3-hydroxy-propylamine
3-hydroxylpropylamine
h2n(ch2)3oh
3-hydroxypropyamine
aminopropan-3-ol
h2n-(ch2)3-oh
3-amino -1-propanol
3-amino-1propanol
3-aminopropane-1-ol
3-amino-l-propanol
1-amino-propan-3-ol
3amino-1-propanol
3- aminopropanol
DTXSID0059746
3-aminopropanol-(1)
nh2(ch2)3oh
W-109520
BP-31041
F2190-0368
0d8 ,
mfcd00008223
3-amino-1-propanol, analytical standard
propanolamine, united states pharmacopeia (usp) reference standard
D77871
3-amino-1-propanol, pharmaceutical secondary standard; certified reference material
3-aminopropanol (propanolamine)
3-aminopropanol; 3-amino-1-propanol
CS-W020089
nsc 7766; propanolamine
Q223042
STL194299
STR03558
SB83761
EN300-16772
Z56771034
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
primary alcoholA primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.
primary amineA compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group.
propanolamine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID158688Inhibitory activity against Plasmodium falciparum1997Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22
Antimalarial activity of molecules interfering with Plasmodium falciparum phospholipid metabolism. Structure-activity relationship analysis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's6 (60.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 42.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index42.47 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.47 (4.65)
Search Engine Demand Index57.92 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (42.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
monoisopropanolamine
monoisopropanolamine: possible industrial pollutant; structure. 1-aminopropan-2-ol : Any amino alcohol that is propan-2-ol substituted by an amino group at position 1.		2.420amino alcohol;
secondary alcohol		Escherichia coli metabolite
betaine
glycine betaine : The amino acid betaine derived from glycine.		1.9910amino-acid betaine;
glycine derivative		fundamental metabolite
cadaverine
[no description available]		1.9910alkane-alpha,omega-diamineDaphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite
trimethylenediamine
trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.		2.0310alkane-alpha,omega-diaminehuman metabolite;
mouse metabolite;
reagent
ethanolamine
[no description available]		3.8630ethanolamines;
primary alcohol;
primary amine		Escherichia coli metabolite;
human metabolite;
mouse metabolite
meclofenoxate
Meclofenoxate: An ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid.		1.9910monocarboxylic acid
2-aminopropanol
2-aminopropanol: RN given refers to cpd without isomeric designation. 2-aminopropan-1-ol : An amino alcohol that is alanine in which the carboxy group has been reduced to the corresponding alcohol.		2.420amino alcohol;
primary alcohol;
primary amino compound
hexamethonium bromide
[no description available]		1.9910
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.		210chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant
cetrimonium bromide
cetyltrimethylammonium bromide : The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide.		1.9910organic bromide salt;
quaternary ammonium salt		detergent;
surfactant
cysteamine
Cysteamine: A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.. cysteamine : An amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.		1.9910amine;
thiol		geroprotector;
human metabolite;
mouse metabolite;
radiation protective agent
acetylcholine chloride
acetylcholine chloride : The chloride salt of acetylcholine, and a parasympatomimetic drug.		1.9910quaternary ammonium salt
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.9210amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
2-diethylaminoethanol
2-diethylaminoethanol: RN given refers to unlabeled parent cpd. 2-diethylaminoethanol : A member of the class of ethanolamines that is aminoethanol in which the hydrogens of the amino group are replaced by ethyl groups.		1.9910ethanolamines;
primary alcohol;
tertiary amino compound
deanol
Deanol: An antidepressive agent that has also been used in the treatment of movement disorders. The mechanism of action is not well understood.. N,N-dimethylethanolamine : A tertiary amine that is ethanolamine having two N-methyl substituents.		1.9910ethanolamines;
tertiary amine		curing agent;
radical scavenger
n-methylaminoethanol
N-methylaminoethanol: structure. N-methylethanolamine : An ethanolamine compound having an N-methyl substituent.		2.9210ethanolamines
diethanolamine
diethanolamine: RN given refers to parent cpd. diethanolamine : A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.		1.9910ethanolamineshuman xenobiotic metabolite
propyl ether
[no description available]		2.0110
zephiramine
[no description available]		1.9910
sterogenol
hexadecylpyridinium bromide: structure in first source. cetylpyridinium bromide : A pyridinium salt that has N-hexadecylpyridinium as the cation and bromide as the anion.		1.9910bromide salt;
pyridinium salt		antiseptic drug;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
surfactant
decamethonium dibromide
[no description available]		1.9910
2-amino-2-methyl-1-propanol
2-amino-2-methyl-1-propanol: RN given refers to parent cpd		1.9910
3,3-dimethylbutan-1-ol
3,3-dimethylbutan-1-ol: structure		1.9910
dodecyltrimethylammonium bromide
dodecyltrimethylammonium bromide : A quarternary ammonium cation having one dodecyl and three methyl substituents around the central nitrogen.		1.9910bromide salt;
quaternary ammonium salt		surfactant
2-amino-1-butanol
2-amino-1-butanol: structure		3.3220
cerium
Cerium: An element of the rare earth family of metals. It has the atomic symbol Ce, atomic number 58, and atomic weight 140.12. Cerium is a malleable metal used in industrial applications.		2.110f-block element atom;
lanthanoid atom
chromium
Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.		2.0510chromium group element atom;
metal allergen		micronutrient
serinol
serinol: RN given refers to cpd without isomeric designation		1.9910
ceric oxide
ceric oxide: RN given refers to cpd with MF CeO2. ceric oxide : A metal oxide with formula CeO2. It is used for polishing glass, in coatings for infra-red filters to prevent reflection, and as an oxidant and catalyst in organic synthesis.		2.110cerium molecular entity;
metal oxide
4,6-diacetylresorcinol
4,6-diacetylresorcinol: structure in first source		7.0310
epolamine
[no description available]		1.9910pyrrolidines
arachidonic acid
icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.		1.9910icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		2.92101,2-diacyl-sn-glycero-3-phosphocholine
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials