Compounds > 3,6-dibenzyl-1,2-dihydro-1,2,4,5-tetraazine

Page last updated: 2024-11-09

3,6-dibenzyl-1,2-dihydro-1,2,4,5-tetraazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	725764
CHEMBL ID	377586
CHEBI ID	183761

Synonyms (13)

Synonym
CBMICRO_013812
BIM-0013889.P001
SR-01000637638-1
HMS1661B09
CHEMBL377586
CHEBI:183761
3,6-dibenzyl-1,4-dihydro-1,2,4,5-tetrazine
3,6-dibenzyl-1,2-dihydro-1,2,4,5-tetraazine
CCG-3888
CB07592
smsf0012628
STL477403
3,6-dibenzyl-1,2-dihydro-1,2,4,5-tetrazine

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
benzenes	Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID268093	Antiproliferative activity against mouse P388 cell line at 0.1 umol/L by MTT method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268085	Antiproliferative activity against human A549 cell line at 100 umol/L by SRB method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268090	Antiproliferative activity against mouse P388 cell line at 100 umol/L by MTT method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268091	Antiproliferative activity against mouse P388 cell line at 10 umol/L by MTT method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268089	Antiproliferative activity against human A549 cell line at 0.01 umol/L by SRB method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268086	Antiproliferative activity against human A549 cell line at 10 umol/L by SRB method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268094	Antiproliferative activity against mouse P388 cell line at 0.01 umol/L by MTT method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268088	Antiproliferative activity against human A549 cell line at 0.1 umol/L by SRB method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268092	Antiproliferative activity against mouse P388 cell line at 1 umol/L by MTT method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID268087	Antiproliferative activity against human A549 cell line at 1 umol/L by SRB method	2006	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 16, Issue:14	Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).	2014	Journal of biomolecular screening, Jul, Volume: 19, Issue:6	A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808	Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159607	Screen for inhibitors of RMI FANCM (MM2) intereaction	2016	Journal of biomolecular screening, Jul, Volume: 21, Issue:6	A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (16.67)	29.6817
2010's	4 (66.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.68

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.68 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.63 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.68)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
clofentezine clofentezine: acaricide, primarily a mite ovicide; structure given in first source. clofentezine : A tetrazine that is 1,2,4,5-tetrazine in which both of the hydrogens have been replaced by o-chlorophenyl groups.	2.03	1	0	monochlorobenzenes; organochlorine acaricide; tetrazine	mite growth regulator; tetrazine acaricide

Condition	Indicated	Relationship Strength	Studies	Trials
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	0	2.03	1	0
Cancer of Liver [description not available]	0	2.03	1	0
Cancer of Lung [description not available]	0	2.03	1	0
Liver Neoplasms Tumors or cancer of the LIVER.	0	2.03	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	0	2.03	1	0
Encephalitis, Polio [description not available]	0	2.06	1	0
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	0	2.06	1	0
Plasmodium falciparum Malaria [description not available]	0	2.1	1	0
Malaria, Falciparum Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.	0	2.1	1	0
Anemia, Fanconi [description not available]	0	2.13	1	0
Fanconi Anemia Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)	0	2.13	1	0