3,4-dichloro-1-butene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,4-dichloro-1-butene: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	12971
CHEMBL ID	3182884
SCHEMBL ID	190697
MeSH ID	M0134071

Synonyms (40)

Synonym
ia19eyw12d ,
ccris 8555
ec 212-079-0
4-01-00-00772 (beilstein handbook reference)
unii-ia19eyw12d
1-butene, 3,4-dichloro-
1,2-dichloro-3-butene
3,4-dichlorobut-1-ene
3,4-dichloro-1-butene
3,4-dichlorobutene-1
1-butene, 3,4-dichloro-, (+-)-
brn 1739135
hsdb 5751
einecs 212-079-0
760-23-6
inchi=1/c4h6cl2/c1-2-4(6)3-5/h2,4h,1,3h
3,4-dichloro-1-butene, 98%
D1072
NCGC00249032-01
NCGC00256397-01
dtxsid8022113 ,
cas-760-23-6
dtxcid902113
tox21_302814
tox21_201361
NCGC00258913-01
AKOS006220765
FT-0614245
SCHEMBL190697
1-butene, 3,4-dichloro-, (+/-)-
3,4-dichlorobut-1-ene [hsdb]
1,2-dichlorobut-3-ene
CHEMBL3182884
mfcd00000947
2-undecynoicacidmethylester
3,4-dichloro-1 -butene
Q27280624
D89774
BS-23013
EN300-7426254

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
"In dose-response analysis, regression analysis and hypothesis testing are the main tools of choice."	( Reconsidering sufficient and optimal test design in acute toxicity testing. Jager, T, 2014)	0.4

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (8)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	22.2771	3.1890	29.8841	59.4836	AID1224846
AR protein	Homo sapiens (human)	Potency	28.4620	0.0002	21.2231	8,912.5098	AID743035; AID743063
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	35.0065	0.0030	41.6115	22,387.1992	AID1159552; AID1159555
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	13.9363	0.0015	30.6073	15,848.9004	AID1224841
pregnane X nuclear receptor	Homo sapiens (human)	Potency	31.3559	0.0054	28.0263	1,258.9301	AID1346982
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	22.1112	0.0002	29.3054	16,493.5996	AID743069; AID743075
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	63.0957	0.0010	19.4141	70.9645	AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	0.7079	0.0237	23.2282	63.5986	AID743223
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (33.33)	18.7374
1990's	1 (16.67)	18.2507
2000's	1 (16.67)	29.6817
2010's	1 (16.67)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.95 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.73 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.95)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
naphthalene [no description available]	2.1	1	naphthalenes; ortho-fused bicyclic arene	apoptosis inhibitor; carcinogenic agent; environmental contaminant; mouse metabolite; plant metabolite; volatile oil component
diazinon Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.. diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.	2.1	1	organic thiophosphate; pyrimidines	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; nematicide; xenobiotic
bromoacetate [no description available]	7.41	1	carboxylic acid; organohalogen compound
isoprene isoprene: used in manufacture of ''synthetic'' rubber, butyl rubber; copolymer in production of elastomers; structure. isoprene : A hemiterpene with the formula CH2=C(CH3)CH=CH2; the monomer of natural rubber and a common structure motif to the isoprenoids, a large class of other naturally occurring compounds.	1.98	1	alkadiene; hemiterpene; volatile organic compound	plant metabolite
citronellal citronellal: aldehyde of citronellol; found in citronella oil. citronellal : A monoterpenoid, the main component of citronella oil which gives it its distinctive lemon aroma.	7.41	1	aldehyde; monoterpenoid	antifungal agent; metabolite
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2	1	titanium group element atom
ozone Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.	2	1	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer
titanium dioxide titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.	2	1	titanium oxides	food colouring
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.41	1	benzenes; phenyl acetates
1,4-dichloro-2-butene 1,4-dichloro-2-butene: RN given refers to parent cpd without isomeric designation; structure	2.89	4	organochlorine compound

Condition	Indicated	Relationship Strength	Studies	Trials
Encephalopathy, Toxic [description not available]	0	2.41	1	0
Abnormalities, Autosome [description not available]	0	1.96	1	0

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