Compounds > 3,3'-dihydroxy-alpha,beta-diethylstilbene
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3,3'-dihydroxy-alpha,beta-diethylstilbene

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Description

3,3'-dihydroxy-alpha,beta-diethylstilbene: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3036170
CHEMBL ID33596
MeSH IDM0091713

Synonyms (17)

Synonym
3,3'-diethylstilbestrol
5959-71-7
3,4-bis(m-hydroxyphenyl)hex-3-ene
3,4-bis(3-hydroxyphenyl)hex-3-ene
3,3'-dihydroxy-alpha,beta-diaethylstilben
phenol, 3,3'-(1,2-diethyl-1,2-ethenediyl)bis-
80149-87-7
(e)-3,4-bis(m-hydroxyphenyl)hex-3-ene
phenol, 3,3'-(1,2-diethyl-1,2-ethenediyl)bis-, (e)-
3,3'-stilbenediol, alpha,alpha'-diethyl-, (e)-
3',3''-diethylstilbestrol
trans-alpha,alpha'-diethyl-3,3'-stilbenediol
3,3'-des
3,3'-dihydroxy-alpha,beta-diaethylstilben [german]
3,3'-dihydroxy-alpha,beta-diethylstilbene
CHEMBL33596
trans-3,3'-dihydroxy-alpha,beta-diathylstilben
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID192134Percent partial remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID123554Effect on estrogen and progesterone receptors positive hormone-dependent postmenopausal human mammary carcinoma tumor growth in nude mice at 1.0 mg/kg/day dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192143Percent progression of DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188935Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 4.0 mg/kg/day (initial tumor number)1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188932Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 1.0 mg/kg/day (initial tumor number)1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192139Percent progression of DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID172219Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192133Percent unchanged DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192138Percent partial remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID69847In vitro relative binding affinity for Estrogen receptor compared to [3H]estradiol1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID172221Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID172218Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 2.0 mg/kg/day (initial tumor size)1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192136Percent remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192137Percent unchanged DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID123555Effect on estrogen and progesterone receptors positive hormone-dependent postmenopausal human mammary carcinoma tumor growth in nude mice at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192141Percent unchanged DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112874Antiuterotrophic activity in mice at 2.5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115539Percent inhibition of estrone-stimulated uterine growth in immature mouse at 5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115410Percent inhibition of estrone-stimulated uterine growth in immature mouse at 2.5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112878Antiuterotrophic activity in mice at 5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112876Antiuterotrophic activity in mice at 25 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115412Percent inhibition of estrone-stimulated uterine growth in immature mouse at 25 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112877Antiuterotrophic activity in mice at 50 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192140Percent remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115538Percent inhibition of estrone-stimulated uterine growth in immature mouse at 50 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188933Effect on DMBA-induced hormone-dependent mammary carcinoma tumor number in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192142Percent partial remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188936Effect on DMBA-induced hormone-dependent mammary carcinoma tumor number in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192135Percent progression of DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192131Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID71119Relative Binding Affinity (RBA) for calf uterine estrogen receptor1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes.
AID188934Effect on DMBA-induced hormone-dependent mammary carcinoma tumor number in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192132Percent remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		1.9710sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
hexestrol
[no description available]		2.3820stilbenoid
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		2.372017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
4-nitroquinoline-1-oxide
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.		1.9710C-nitro compound;
quinoline N-oxide		carcinogenic agent
diethylstilbestrol
Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed). diethylstilbestrol : An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.		8.3570olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		1.9810stilbene
3,3',4,5'-tetrahydroxystilbene
3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer. piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.		6.9810catechols;
polyphenol;
resorcinols;
stilbenol		antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
dimethylstilbestrol
dimethylstilbestrol: stilbene derivative with anti-estrogenic & anti-fertility activities; minor descriptor (75-85); on-line & Index Medicus search STILBENES (75-85); RN given refers to cpd without isomeric designation		1.9610stilbenoid
ConditionIndicatedRelationship StrengthStudiesTrials
Hormone-Dependent Neoplasms
[description not available]		01.9610
Experimental Mammary Neoplasms
[description not available]		02.3720
Adenocarcinoma, Basal Cell
[description not available]		01.9510
Breast Cancer
[description not available]		01.9510
Experimental Neoplasms
[description not available]		01.9510
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		01.9510
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9510
Aneuploid
[description not available]		06.9810
Chromosome-Defective Micronuclei
[description not available]		01.9710