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3,3'-dihydroxy-alpha,beta-diethylstilbene

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Description

3,3'-dihydroxy-alpha,beta-diethylstilbene: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3036170
CHEMBL ID33596
MeSH IDM0091713

Synonyms (17)

Synonym
3,3'-diethylstilbestrol
5959-71-7
3,4-bis(m-hydroxyphenyl)hex-3-ene
3,4-bis(3-hydroxyphenyl)hex-3-ene
3,3'-dihydroxy-alpha,beta-diaethylstilben
phenol, 3,3'-(1,2-diethyl-1,2-ethenediyl)bis-
80149-87-7
(e)-3,4-bis(m-hydroxyphenyl)hex-3-ene
phenol, 3,3'-(1,2-diethyl-1,2-ethenediyl)bis-, (e)-
3,3'-stilbenediol, alpha,alpha'-diethyl-, (e)-
3',3''-diethylstilbestrol
trans-alpha,alpha'-diethyl-3,3'-stilbenediol
3,3'-des
3,3'-dihydroxy-alpha,beta-diaethylstilben [german]
3,3'-dihydroxy-alpha,beta-diethylstilbene
CHEMBL33596
trans-3,3'-dihydroxy-alpha,beta-diathylstilben
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (33)

Assay IDTitleYearJournalArticle
AID192134Percent partial remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID123554Effect on estrogen and progesterone receptors positive hormone-dependent postmenopausal human mammary carcinoma tumor growth in nude mice at 1.0 mg/kg/day dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192143Percent progression of DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188935Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 4.0 mg/kg/day (initial tumor number)1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188932Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 1.0 mg/kg/day (initial tumor number)1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192139Percent progression of DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID172219Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192133Percent unchanged DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192138Percent partial remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID69847In vitro relative binding affinity for Estrogen receptor compared to [3H]estradiol1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID172221Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID172218Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 2.0 mg/kg/day (initial tumor size)1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192136Percent remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192137Percent unchanged DMBA-induced hormone-dependent mammary carcinoma in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID123555Effect on estrogen and progesterone receptors positive hormone-dependent postmenopausal human mammary carcinoma tumor growth in nude mice at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192141Percent unchanged DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112874Antiuterotrophic activity in mice at 2.5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115539Percent inhibition of estrone-stimulated uterine growth in immature mouse at 5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115410Percent inhibition of estrone-stimulated uterine growth in immature mouse at 2.5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112878Antiuterotrophic activity in mice at 5 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112876Antiuterotrophic activity in mice at 25 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115412Percent inhibition of estrone-stimulated uterine growth in immature mouse at 25 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID112877Antiuterotrophic activity in mice at 50 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192140Percent remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID115538Percent inhibition of estrone-stimulated uterine growth in immature mouse at 50 ug dose1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188933Effect on DMBA-induced hormone-dependent mammary carcinoma tumor number in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192142Percent partial remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID188936Effect on DMBA-induced hormone-dependent mammary carcinoma tumor number in rats at 4.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192135Percent progression of DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192131Effect on DMBA-induced hormone-dependent mammary carcinoma tumor growth in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID71119Relative Binding Affinity (RBA) for calf uterine estrogen receptor1986Journal of medicinal chemistry, Mar, Volume: 29, Issue:3
Influence of alkyl-chain fluorination on the action of mammary tumor inhibiting 2,3-bis(hydroxyphenyl)butanes and 2,3-bis(hydroxyphenyl)but-2-enes.
AID188934Effect on DMBA-induced hormone-dependent mammary carcinoma tumor number in rats at 2.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
AID192132Percent remission of DMBA-induced hormone-dependent mammary carcinoma in rats at 1.0 mg/kg/day1982Journal of medicinal chemistry, Feb, Volume: 25, Issue:2
Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]