Compounds > 3,3',4,4'-tetrabromobiphenyl
Page last updated: 2024-12-07

3,3',4,4'-tetrabromobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

3,3',4,4'-Tetrabromobiphenyl, also known as tetrabromodiphenyl ether (TBDE), is a brominated flame retardant (BFR) that was widely used in plastics, textiles, and electronics. It has been found to be persistent in the environment and can accumulate in the food chain, potentially leading to adverse health effects. TBDE is a synthetic compound that is manufactured through the bromination of biphenyl. It has been studied extensively due to its environmental persistence, bioaccumulation, and potential toxicity to humans and wildlife. Research on TBDE has focused on its synthesis, environmental fate, and potential health effects. TBDE has been shown to have endocrine disrupting properties and has been linked to developmental and reproductive problems in animals. Due to these concerns, TBDE has been phased out in many countries. Ongoing research continues to investigate the long-term impacts of TBDE exposure on human health and the environment.'

Cross-References

ID SourceID
PubMed CID107953
SCHEMBL ID21820782
MeSH IDM0111522

Synonyms (15)

Synonym
1,1'-biphenyl, 3,3',4,4'-tetrabromo-
ccris 5775
3,3',4,4'-tetrabromobiphenyl
77102-82-0
1,2-dibromo-4-(3,4-dibromophenyl)benzene
unii-o9i88185bk
o9i88185bk ,
1,1'-biphenyl,3,3',4,4'-tetrabromo-
pbb 77
3,4,3',4'-tetrabromobiphenyl
DTXSID4074770
pbb 077
3,3,4,4-tetrabromobiphenyl
SCHEMBL21820782
Q27285518

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The results suggest that even though the receptor-binding affinities imply that TBB should be more toxic than HBB, it is less toxic than HBB because it is metabolized."( Toxicity of 3,4,5,3',4',5'-hexabrominated biphenyl and 3,4,3',4'-tetrabrominated biphenyl.
Aust, SD; Millis, CD; Mills, RA; Sleight, SD, 1985)		0.27
" When administered at the same dose, 2,2',5,5'-tetrabromobiphenyl did not elicit any observed toxic effects."( Toxicity of 3,3',4,4'- and 2,2',5,5'-tetrabromobiphenyl: correlation of activity with aryl hydrocarbon hydroxylase induction and lack of protection by antioxidants.
Andres, JL; Lovering, SL; Robertson, LW; Safe, SH, 1983)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.21

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.21 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.21)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-methylcholanthrene
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.. 3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.		1.9610ortho- and peri-fused polycyclic arenearyl hydrocarbon receptor agonist;
carcinogenic agent
phenobarbital
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.		1.9610barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		7.110chromium group element atommicronutrient
2,4,5,2',4',5'-hexabromobiphenyl
2,4,5,2',4',5'-hexabromobiphenyl: RN given refers to parent cpd. 2,2',4,4',5,5'-hexabromobiphenyl : A polybromobiphenyl that is biphenyl in which the hydrogens at positions 2, 2', 4, 4', 5, and 5' have been replace by bromines.		1.9610brominated flame retardant;
polybromobiphenyl
3,3',4,4',5,5'-hexabromobiphenyl
[no description available]		7.6630
firemaster bp-6
[no description available]		6.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9710