Compounds > 3'-(3-(2-chloroethyl)-3-nitrosourea)-3'-deoxythymidine
Page last updated: 2024-12-07

3'-(3-(2-chloroethyl)-3-nitrosourea)-3'-deoxythymidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID125188
CHEMBL ID3245300
SCHEMBL ID11020038
MeSH IDM0090070

Synonyms (10)

Synonym
1-(2-chloroethyl)-3-[(2s,3s,5r)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]-1-nitrosourea
3'-ctnu
65174-26-7
thymidine, 3'-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-3'-deoxy-
3'-(3-(2-chloroethyl)-3-nitrosourea)-3'-deoxythymidine
CHEMBL3245300
SCHEMBL11020038
3'-(3-chloroethyl-3-nitrosoureido)-3'-deoxythymidine
1-[3-({[(2-chloroethyl)(nitroso)amino](hydroxy)methylidene}amino)-2,3-dideoxypentofuranosyl]-4-hydroxy-5-methylpyrimidin-2(1h)-one
DTXSID60983749
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1131540Carbamoylating activity of the compound at 5 umol by liquid scintillation spectrometry in presence of [14C]-lysine relative to 1,3-bis-(2-chloroethyl)-1-nitrosourea1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine.
AID1131538Cytotoxicity against mouse L1210 cells after 72 hrs by coulter counter analysis1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine.
AID1131539Alkylating activity of the compound relative to 1,3-bis-(2-chloroethyl)-1-nitrosourea1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
Antineoplastic agents. 1. Synthesis and antineoplastic activities of chloroethyl- and methylnitrosourea analogues of thymidine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carmustine
Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed). carmustine : A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.		2.6630N-nitrosoureas;
organochlorine compound		alkylating agent;
antineoplastic agent
thymidine
[no description available]		2.8840pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		03.0650
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9610
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9610
Experimental Leukemia
[description not available]		01.9610