3-(thymin-1'-yl)-2-propenal: structure given in first source; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 6439704 |
| CHEMBL ID | 176501 |
| SCHEMBL ID | 6510682 |
| MeSH ID | M0130045 |
| Synonym |
|---|
| ccris 8713 |
| 2-propenal, 3-(3,4-dihydro-5-methyl-2,4-dioxo-1(2h)-pyrimidinyl)- |
| thymine propenal |
| thymine-n(1)-2-propenal |
| 3-(thymin-1'-yl)-2-propenal |
| CHEMBL176501 |
| (e)-3-(5-methyl-2,4-dioxopyrimidin-1-yl)prop-2-enal |
| 85394-19-0 |
| AM20110226 |
| (2e)-3-(5-methyl-2,4-dioxo-3,4-dihydro-1(2h)-pyrimidinyl)-2-propenal |
| DTXSID20234603 |
| SCHEMBL6510682 |
| CDPXAPVOBNKPPD-NSCUHMNNSA-N |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID88670 | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein | 1984 | Journal of medicinal chemistry, Aug, Volume: 27, Issue:8 | Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines. |
| AID88672 | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA | 1984 | Journal of medicinal chemistry, Aug, Volume: 27, Issue:8 | Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines. |
| AID22173 | Compound was evaluated for its half-life when nucleophile was added in solution buffered at pH 7.2 in the presence of aminoethanol | 1984 | Journal of medicinal chemistry, Aug, Volume: 27, Issue:8 | Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines. |
| AID88671 | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive thymidine into DNA | 1984 | Journal of medicinal chemistry, Aug, Volume: 27, Issue:8 | Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines. |
| AID22174 | Compound was evaluated for its half-life when nucleophile was added in solution buffered at pH 7.2 in the presence of glutathione | 1984 | Journal of medicinal chemistry, Aug, Volume: 27, Issue:8 | Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines. |
| AID88705 | Inhibition of HeLa cells growth (cytotoxicity) | 1984 | Journal of medicinal chemistry, Aug, Volume: 27, Issue:8 | Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.67) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||