Compounds > 3-(thymin-1'-yl)-2-propenal
Page last updated: 2024-12-11

3-(thymin-1'-yl)-2-propenal

Description

3-(thymin-1'-yl)-2-propenal: structure given in first source; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6439704
CHEMBL ID176501
SCHEMBL ID6510682
MeSH IDM0130045

Synonyms (13)

Synonym
ccris 8713
2-propenal, 3-(3,4-dihydro-5-methyl-2,4-dioxo-1(2h)-pyrimidinyl)-
thymine propenal
thymine-n(1)-2-propenal
3-(thymin-1'-yl)-2-propenal
CHEMBL176501
(e)-3-(5-methyl-2,4-dioxopyrimidin-1-yl)prop-2-enal
85394-19-0
AM20110226
(2e)-3-(5-methyl-2,4-dioxo-3,4-dihydro-1(2h)-pyrimidinyl)-2-propenal
DTXSID20234603
SCHEMBL6510682
CDPXAPVOBNKPPD-NSCUHMNNSA-N
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID88670Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.
AID88672Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.
AID22173Compound was evaluated for its half-life when nucleophile was added in solution buffered at pH 7.2 in the presence of aminoethanol1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.
AID88671Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive thymidine into DNA1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.
AID22174Compound was evaluated for its half-life when nucleophile was added in solution buffered at pH 7.2 in the presence of glutathione1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.
AID88705Inhibition of HeLa cells growth (cytotoxicity)1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Synthesis and biological activity of a new class of cytotoxic agents: N-(3-oxoprop-1-enyl)-substituted pyrimidines and purines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.67 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
adenine
[no description available]		2.39206-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
hydrogen carbonate
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.. hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.		1.9910carbon oxoanioncofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		1.9910monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
thymine
[no description available]		3.0850pyrimidine nucleobase;
pyrimidone		Escherichia coli metabolite;
human metabolite;
mouse metabolite
kinetin
Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.. cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.		1.99106-aminopurines;
furans		cytokinin;
geroprotector
thymidine
[no description available]		1.9610pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		210aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
furaldehyde
Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.		1.9910aldehyde;
furans		Maillard reaction product;
metabolite
acrolein
[no description available]		1.9810enalherbicide;
human xenobiotic metabolite;
toxin
propylene
propylene: structure		1.9810alkene;
gas molecular entity		refrigerant;
xenobiotic
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		210dialdehydebiomarker
alkenes
[no description available]		1.9810
peroxynitric acid
[no description available]		1.9910nitrogen oxoacid
9-(3-oxoprop-1-enyl)adenine
9-(3-oxoprop-1-enyl)adenine: structure in first source		2.6730
guanine
[no description available]		1.99102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
8-hydroxyguanine
7,8-dihydro-8-oxoguanine: was substituted for guanine at G(8), G(9), G(14), or G(15) in the human telomeric oligonucleotide 5'-d[AGGGTTAG(8)G(9)GTT AG(14)G(15)GTTAGGGTGT]-3'. 7,8-dihydro-8-oxoguanine : An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen.		1.9910oxopurine
8-nitroguanine
[no description available]		1.9910oxopurine
ConditionIndicatedRelationship StrengthStudiesTrials
chemdatabank.com