Compounds > 3-(3-hydroxyphenyl)-3-hydroxypropanoic acid
Page last updated: 2024-11-07

3-(3-hydroxyphenyl)-3-hydroxypropanoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-(3-hydroxyphenyl)-3-hydroxypropanoic acid : A dihydroxy monocarboxylic acid that is 3-hydroxypropanoic acid substituted by a 3-hydroxyphenyl group at position 3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID102959
CHEBI ID86369
SCHEMBL ID4957161
MeSH IDM0123763

Synonyms (48)

Synonym
mhpha
3247-75-4
3-hydroxy-3-(3-hydroxyphenyl)propanoic acid
A5957
3-hydroxy-3-(3-hydroxy-phenyl)-propionic acid
1-chloro-4-fluoro-2-methyl-benzene
A5819
3-(3-hydroxyphenyl)-3-hydroxypropionic acid
beta-(meta-hydroxyphenyl)hydracrylic acid
3-(3-hydroxyphenyl)-3-hydroxypropanoic acid
AKOS011682178
9iv9236grd ,
benzenepropanoic acid, beta,3-dihydroxy-
unii-9iv9236grd
SCHEMBL4957161
3-hydroxy-3-(3-hydroxyphenyl)propionic acid
CHEBI:86369
hphpa
3-(m-hydroxyphenyl)hydracrylic acid
b-(m-hydroxyphenyl)hydracrylic acid
3'-hydroxyphenylhydracrylic acid
beta-(m-hydroxyphenyl)hydracrylic acid
3-hydroxyphenyl-hydracrylic acid
3-(3-hydroxyphenyl)hydracrylic acid
(3-hydroxyphenyl)hydracrylic acid
ag-f-08597
benzenepropanoic acid, .beta.,3-dihydroxy-
hmdb02643
hydracrylic acid, 3-(m-hydroxyphenyl)-
.beta.-(m-hydroxyphenyl)hydracrylic acid
.beta.-(meta-hydroxyphenyl)hydracrylic acid
3-(3'-hydroxyphenyl)hydracrylic acid
.beta.-m-hydroxyphenylhydracrylic acid
b-(m-hydroxyphenyl)hydracrylate
(3-hydroxyphenyl)hydracrylate
3-(3-hydroxyphenyl)-3-hydroxypropionate
3-(3-hydroxyphenyl)-3-hydroxypropanoate
3-(3-hydroxyphenyl)hydracrylate
beta-(m-hydroxyphenyl)hydracrylate
DTXSID00863132
Q27159109
|a-(m-hydroxyphenyl)hydracrylic acid
3-(m-hydroxyphenyl)hydracrylate
EN300-1850114
PD165849
3-hydroxy-3-(3-hydroxyphenyl)propanoicacid
HY-113231
CS-0059368
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
dihydroxy monocarboxylic acidAny hydroxy monocarboxylic acid carrying at least two hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
Flavan-3-ol metabolic pathway070

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.85 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxyphenylacetic acid
4-hydroxyphenylacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.		2.3720monocarboxylic acid;
phenols		fungal metabolite;
human metabolite;
mouse metabolite;
plant metabolite
hippuric acid
hippuric acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591. N-benzoylglycine : An N-acylglycine in which the acyl group is specified as benzoyl.		1.9610N-acylglycinehuman blood serum metabolite;
uremic toxin
phenytoin
[no description available]		1.9610imidazolidine-2,4-dioneanticonvulsant;
drug allergen;
sodium channel blocker;
teratogenic agent
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		2.0510amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
3-hydroxybenzeneacetic acid
3-hydroxybenzeneacetic acid: metabolite of L-dopa; structure. 3-hydroxyphenylacetic acid : A monocarboxylic acid that is phenylacetic acid in which the hydrogen at position 3 on the benzene ring is replaced by a hydroxy group.		2.1310monocarboxylic acid;
phenols		human xenobiotic metabolite
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0510glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
indican
[no description available]		2.2110beta-D-glucoside;
exopolysaccharide;
indolyl carbohydrate
3-hydroxyhippuric acid
3-hydroxyhippuric acid: a kynureninase inhibitor; structure in first source. m-hydroxyhippuric acid : An N-acylglycine that is hippuric acid (N-benzoylglycine) substituted at position 3 on the phenyl ring by a hydroxy group.		2.1310N-acylglycine;
phenols		metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Autism
[description not available]		02.7930
Dementia Praecox
[description not available]		02.5120
Autistic Disorder
A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)		02.7930
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.		02.5120
Autism Spectrum Disorder
Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)		02.1310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1310
Clostridioides difficile Infection
[description not available]		02.0510
Antibiotic-Associated Colitis
[description not available]		02.0510
Acute Disease
Disease having a short and relatively severe course.		02.0510
Clostridium Infections
Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species.		02.0510
Enterocolitis, Pseudomembranous
An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.		02.0510
Pleural Effusion
Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.		01.9610
Uremia
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.		02.3720