Page last updated: 2024-11-08

3-(2-Methylpropanoyloxy)-8-(2-methylbutanoyloxy)-9,10-epoxy-p-mentha-1,3,5-triene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID354159
CHEMBL ID1549418
CHEBI ID173230

Synonyms (29)

Synonym
3-(2-methylpropanoyloxy)-8-(2-methylbutanoyloxy)-9,10-epoxy-p-mentha-1,3,5-triene
[2-[4-methyl-2-(2-methylpropanoyloxy)phenyl]oxiran-2-yl]methyl 2-methylbutanoate
CHEBI:173230
nsc-604987
NSC604987 ,
10-isovaleryloxy-8,9-epoxythymol-3-isovalerate
thymol derivative from inula crithmoides
thymol derivative
ACON1_001251
MEGXP0_001145
MLS000876981
smr000440687
NCGC00169532-01
BRD-A13575466-001-01-8
(2-{4-methyl-2-[(2-methylpropanoyl)oxy]phenyl}oxiran-2-yl)methyl 2-methylbutanoate
CHEMBL1549418
8,9-epoxy-3-isobutyryloxy-10-(2-methylbutanoyl)thymol
22518-07-6
AKOS037515354
(2-(2-(isobutyryloxy)-4-methylphenyl)oxiran-2-yl)methyl 2-methylbutanoate
8,?9-?epoxy-?3-?isobutyryloxy-?10-?(2-?methylbutanoyl)?thymol
HY-N6844
CS-0100263
10isovaleryloxy-8,9-epoxythymol-3-isovalerate
XI172933
(2-(2-(isobutyryloxy)-4-methylphenyl)oxiran-2-yl)methyl2-methylbutanoate
DTXSID101132477
[2-[4-methyl-2-(2-methyl-1-oxopropoxy)phenyl]-2-oxiranyl]methyl 2-methylbutanoate
PD125099
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
benzoate esterEsters of benzoic acid or substituted benzoic acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency6.75800.003245.467312,589.2998AID2517; AID2572; AID2573
serine-protein kinase ATM isoform aHomo sapiens (human)Potency31.62280.707925.111941.2351AID485349
DNA polymerase betaHomo sapiens (human)Potency39.81070.022421.010289.1251AID485314
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency89.12510.010323.856763.0957AID2662
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency70.79460.050127.073689.1251AID588590
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency22.38720.00798.23321,122.0200AID2546
gemininHomo sapiens (human)Potency0.81990.004611.374133.4983AID624297
Glutamate receptor 1Rattus norvegicus (Norway rat)Potency11.22020.01418.602439.8107AID2572
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency11.22020.001551.739315,848.9004AID2572
Glutamate receptor 3Rattus norvegicus (Norway rat)Potency11.22020.01418.602439.8107AID2572
Glutamate receptor 4Rattus norvegicus (Norway rat)Potency11.22020.01418.602439.8107AID2572
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 1Rattus norvegicus (Norway rat)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1866559Inhibition of MAPK/ERK signalling pathway in human A2058 cells harbouring BRAF V600E and PTEN deletion mutant coexpressing ERK-KTR fused mScarlett fluorophore incubated for 2 hrs by high-content screening microscopic analysis2022Journal of natural products, 04-22, Volume: 85, Issue:4
High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma.
AID1866560Inhibition of PI3K/AKT signalling pathway in patient-derived MM121224 cells harboring BRAF V600E/NRAS Q61K mutant coexpressing mutated forkhead box protein 1 allele fused mNeonGreen fluorophore incubated for 2 hrs2022Journal of natural products, 04-22, Volume: 85, Issue:4
High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma.
AID1866561Inhibition of MAPK/ERK signalling pathway in patient-derived MM121224 cells harboring BRAF V600E/NRAS Q61K mutant coexpressing ERK-KTR fused mScarlett fluorophore incubated for 2 hrs by high-content screening microscopic analysis2022Journal of natural products, 04-22, Volume: 85, Issue:4
High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma.
AID1866573Thermal stability of compound assessed as compound degradation at -80 to -20 degC measured after 15 months by HPLC-ELSD analysis2022Journal of natural products, 04-22, Volume: 85, Issue:4
High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma.
AID1866558Inhibition of PI3K/AKT signalling pathway in human A2058 cells harbouring BRAF V600E and PTEN deletion mutant coexpressing mutated forkhead box protein 1 allele fused mNeonGreen fluorophore incubated for 2 hrs by high-content screening microscopic analysi2022Journal of natural products, 04-22, Volume: 85, Issue:4
High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]