2-phenyloxazolone profile

2-Phenyloxazolone, also known as benzoxazolone, is a heterocyclic compound that has been extensively studied for its versatile applications in organic synthesis, pharmaceuticals, and materials science. Its synthesis typically involves the condensation reaction of benzoyl chloride with glycine, followed by cyclization. 2-Phenyloxazolone exhibits diverse biological activities, including antimicrobial, anti-inflammatory, and anti-cancer properties. Its importance in research stems from its ability to act as a building block for various pharmaceutical agents and its potential to modulate biological pathways. Researchers are interested in exploring its structure-activity relationships, optimizing its biological effects, and developing novel derivatives for therapeutic purposes.'

2-phenyloxazolone: RN given refers to 2-phenyl-5-oxazolone [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-phenyloxazol-5(4H)-one : A 1,3-oxazole having a phenyl substituent at the 2-position and an oxo group at the 5-position. Note that phenyloxazolone is commonly used as a synonym for 4-(ethoxymethylene)-2-phenyloxazol-5-one (PhOx). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	65073
CHEBI ID	60296
SCHEMBL ID	135941
MeSH ID	M0069766

Synonym
NCIOPEN2_000906
phenyloxazolone
2-phenyloxazolin-5-one
2-oxazolin-5-one, 2-phenyl-
5(4h)-oxazolone, 2-phenyl-
2-phenyl-5-oxazolone
1199-01-5
nsc-79500
nsc79500
2-phenyloxazol-5(4h)-one
2-phenyloxazolone
CHEBI:60296 ,
2-phenyl-1,3-oxazol-5(4h)-one
AKOS000369724
2-phenyl-4h-1,3-oxazol-5-one
A18124
2-phenyloxazol-5(4h)-one;2-phenyl-4h-oxazol-5-one
2-phenyl-5(4h)-oxazolone
2-phenyl-4h-oxazol-5-one
einecs 214-840-2
2-phenyloxazol-5-one
nsc 79500
FT-0613343
EPITOPE ID:150812
SCHEMBL135941
DTXSID0061612
2-phenyl-4,5-dihydro-1,3-oxazol-5-one
2-phenyl-2-oxazolin-5-one
QKCKCXFWENOGER-UHFFFAOYSA-N
mfcd00014517
CS-W017933
DS-18397
Q27127174
AMY21617
BAA19901
SY058776

Class	Description
1,3-oxazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	18 (24.00)	18.7374
1990's	41 (54.67)	18.2507
2000's	10 (13.33)	29.6817
2010's	6 (8.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (2.53%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	77 (97.47%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	2.4	2	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	1.98	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
phosphoric acid phosphoric acid: concise etchant is 37% H3PO4. phosphoric acid : A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.	2.04	1	phosphoric acids	algal metabolite; fertilizer; human metabolite; NMR chemical shift reference compound; solvent
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	1.99	1
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	3.67	10	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
digoxigenin Digoxigenin: 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide. A cardenolide which is the aglycon of digoxin. Can be obtained by hydrolysis of digoxin or from Digitalis orientalis L. and Digitalis lanata Ehrh.. digoxigenin : A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis.	1.99	1	12beta-hydroxy steroid; 14beta-hydroxy steroid; 3beta-hydroxy steroid; 3beta-sterol	hapten; plant metabolite
samarium Samarium: An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.	2.04	1	f-block element atom; lanthanoid atom
pyrrolidine [no description available]	2.11	1	azacycloalkane; pyrrolidines; saturated organic heteromonocyclic parent
ruthenium chloride (rucl3) ruthenium chloride: RN given refers to unlabeled cpd	2.04	1
deoxyuridine triphosphate [no description available]	2.46	2	deoxyuridine phosphate; pyrimidine 2'-deoxyribonucleoside 5'-triphosphate	Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite
lr 511 LR 511: structure	1.96	1
6-carboxyfluorescein 6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein	1.99	1	monocarboxylic acid
2-oxindole 2-oxindole: RN given refers to parent cpd; structure. indolin-2-one : An indolinone carrying an oxo group at position 2.	2.11	1	gamma-lactam; indolinone
cellulase Cellulase: An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.. beta-cellotriose : A cellotriose with a beta-configuration at the anomeric position.	1.98	1	cellotriose
oxazolone Oxazolone: Immunologic adjuvant and sensitizing agent.	7.23	75
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.91	4
oligonucleotides [no description available]	1.97	1
4-hydroxy-5-nitrophenyl acetic acid (4-hydroxy-3-nitrophenyl)acetate : A monocarboxylic acid anion that is the conjugate base of (4-hydroxy-3-nitrophenyl)acetic acid, obtained by deprotonation of the carboxy group.	2.01	1	monocarboxylic acid anion
nitrophenols Nitrophenols: PHENOLS carrying nitro group substituents.	2.01	1
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	1.98	1
dinitrobenzenes Dinitrobenzenes: Benzene derivatives which are substituted with two nitro groups in the ortho, meta or para positions.	1.97	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.11	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.11	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.69	3
Contact Dermatitis [description not available]	1.96	1
Delayed Hypersensitivity [description not available]	1.96	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	1.96	1

2-phenyloxazolone

Description

Cross-References

Synonyms (36)

Drug Classes (1)

Research

Studies (75)

Market Indicators

Research Demand Index: 10.05

Study Types