Compounds > 2-naphthyl sulfate
Page last updated: 2024-12-06

2-naphthyl sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-naphthyl sulfate is a sulfate ester of 2-naphthol. It is a metabolite of naphthalene, a common environmental pollutant. 2-naphthyl sulfate is formed in the liver by the action of sulfotransferases. It is then excreted in the urine. 2-naphthyl sulfate has been shown to be a substrate for the enzyme sulfatases, which are involved in the detoxification of xenobiotics. 2-naphthyl sulfate has also been shown to be a weak mutagen in some studies. 2-naphthyl sulfate is studied because it is a common metabolite of naphthalene, and because it has been shown to have some biological activity. It is also used as a marker of exposure to naphthalene.'

2-naphthyl sulfate: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-naphthyl sulfate : An aryl sulfate that is naphthalene in which the hydrogen at position 2 is replaced by a sulfooxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID74428
CHEBI ID167215
SCHEMBL ID1593352
MeSH IDM0177182

Synonyms (22)

Synonym
1733-89-7
2-naphthalenol hydrogen sulfate
2-naphthyl hydrogen sulfate
naphthalen-2-yl hydrogen sulfate
CHEBI:167215
13146-59-3
(naphthalen-2-yl)oxidanesulfonic acid
2-naphthol sulfate
2-naphthyl sulfate
2-naphthalenol, hydrogen sulfate
l3c36e5xd2 ,
unii-l3c36e5xd2
2-naphthalenol, 2-(hydrogen sulfate)
.beta.-naphthol sulfate
.beta.-naphthyl sulfate
2-naphthol, hydrogen sulfate
.beta.-naphthalenesulfuric acid
2-naphthol hydrogen sulfate
SCHEMBL1593352
2-naphthylsulphuric acid
DTXSID60927209
Q27282652

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" 2-Naphthyl sulphate was eliminated from haemolymph with a half-life < 10 h and was excreted in urine."( Pharmacokinetics of 2-naphthol following intrapericardial administration, and formation of 2-naphthyl-beta-D-glucoside and 2-naphthyl sulphate in the American lobster, Homarus americanus.
James, MO; Li, CL, 1997)		0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
aryl sulfate
naphthalenesAny benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.01 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
naphthalene
[no description available]		1.9310naphthalenes;
ortho-fused bicyclic arene		apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component
4-nitrophenol
4-nitrophenol: RN given refers to parent cpd. mononitrophenol : A nitrophenol that is phenol carrying a single nitro substituent at unspecified position.. 4-nitrophenol : A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group.		1.97104-nitrophenolshuman xenobiotic metabolite;
mouse metabolite
1-naphthol
1-naphthol: RN given refers to parent cpd. 1-naphthol : A naphthol carrying a hydroxy group at position 1.. hydroxynaphthalene : Any member of the class of naphthalenes that is naphthalene carrying one or more hydroxy groups.		2.1710naphtholgenotoxin;
human xenobiotic metabolite
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		2.4420naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
s-methylcysteine
S-methylcysteine: RN given refers to parent cpd without isomeric designation. S-methylcysteine : A cysteine derivative that is L-cysteine in which the hydrogen attached to the sulfur is replaced by a methyl group.		2.3110S-alkyl-L-cysteine zwitterion;
S-alkyl-L-cysteine		human urinary metabolite;
plant metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		1.9910D-glucopyranoseepitope;
mouse metabolite
naphthyl sulfate
naphthyl sulfate: RN given refers to parent cpd		1.9310
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		2.3110cysteiniumfundamental metabolite
nitrophenols
Nitrophenols: PHENOLS carrying nitro group substituents.		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials