2-methylhexadecanoic acid profile

2-methylhexadecanoic acid is a branched-chain fatty acid with a methyl group at the 2-position. It is found in various natural sources, including bacteria, plants, and animals. Its synthesis can occur through various biochemical pathways. For example, it can be produced by the action of certain enzymes on hexadecanoic acid (palmitic acid). 2-methylhexadecanoic acid has been shown to exhibit biological activities, including anti-inflammatory and antimicrobial properties. Its importance lies in its role in various biological processes, such as cell signaling and membrane structure. Research on 2-methylhexadecanoic acid aims to understand its biological functions, potential applications in medicine and biotechnology, and its contribution to human health.'

2-methylhexadecanoic acid: see also cpd with unspecified methyl position: 112-39-0 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-methylhexadecanoic acid : A methyl-branched fatty acid that is hexadecanoic (palmitic) acid bearing a methyl substituent at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	117384
CHEBI ID	85057
SCHEMBL ID	112453
MeSH ID	M0107132

Synonym
LMFA01020092
2-methyl-hexadecanoic acid
2-methylpalmitic acid
axpauzgvngewjd-uhfffaoysa-
inchi=1/c17h34o2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16(2)17(18)19/h16h,3-15h2,1-2h3,(h,18,19)
M1026
2-methylhexadecanoic acid
27147-71-3
alpha-methylhexadecanoic acid
CHEBI:85057
alpha-methylpalmitic acid
einecs 248-262-7
hexadecanoic acid, 2-methyl-
SCHEMBL112453
methylhexadecanoic acid
2-methylhexadecanoic acid #
hexadecanoic acid,2-methyl-
mfcd00142945
Q27158306
ethyl 7-chloro-4-(phenylamino)quinoline-3-carboxylate
CS-0205086
FT-0744207
2-methylhexadecanoicacid
T72204
DTXSID30885382
CBA14771

Excerpt	Reference	Relevance
" Besides the alpha-MPS causes an increases Cmax and a shorter tmax of the quinine blood levels."	( [The effect of ion pair formation on the pharmacokinetic properties of drugs. 1. The effect of alpha-methylpalmitic acid on the pharmacokinetics of quinine in rabbits]. Fürst, W; Jirka, M; Loh, HJ; Müller, H; Neubert, R; Schneider, S, 1987)	0.27

Class	Description
branched-chain saturated fatty acid	Any saturated fatty acid with a carbon side-chain or isopropyl termination.
long-chain fatty acid	A fatty acid with a chain length ranging from C13 to C22.
methyl-branched fatty acid	Any branched-chain fatty acid containing methyl branches only.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (18.18)	18.7374
1990's	7 (63.64)	18.2507
2000's	2 (18.18)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (9.09%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2.68	3	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
fenofibrate Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE	1.97	1	aromatic ether; chlorobenzophenone; isopropyl ester; monochlorobenzenes	antilipemic drug; environmental contaminant; geroprotector; xenobiotic
carbamylhydrazine carbamylhydrazine: RN given refers to parent cpd	1.99	1	carbohydrazide; monocarboxylic acid amide; one-carbon compound; ureas
phytanic acid Phytanic Acid: A 20-carbon branched chain fatty acid. In phytanic acid storage disease (REFSUM DISEASE) this lipid may comprise as much as 30% of the total fatty acids of the plasma. This is due to a phytanic acid alpha-hydroxylase deficiency.. phytanic acid : A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15.	1.96	1	branched-chain saturated fatty acid; long-chain fatty acid; methyl-branched fatty acid
coenzyme a [no description available]	1.98	1	adenosine 3',5'-bisphosphate	coenzyme; Escherichia coli metabolite; mouse metabolite
3,7,12-trihydroxycholestan-26-oic acid 3,7,12-trihydroxycholestan-26-oic acid: RN given refers to (3alpha,5beta,7alpha,12alpha)-isomer. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid : A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions.	2.41	2	12alpha-hydroxy steroid; 3alpha-hydroxy steroid; 7alpha-hydroxy steroid; hydroxy monocarboxylic acid; steroid acid	human metabolite
pristanic acid pristanic acid : A branched, long-chain saturated fatty acid composed of pentadecanoic acid having methyl substituents at the 2-, 6-, 10- and 14-positions.	2.4	2	branched-chain saturated fatty acid; long-chain fatty acid; methyl-branched fatty acid	human metabolite
3-methylheptadecanoic acid 3-methylheptadecanoic acid: myocardial metabolic tracer tagged with C-11; RN given refers to unlabeled cpd	2.39	2
palmitoyl coenzyme a Palmitoyl Coenzyme A: A fatty acid coenzyme derivative which plays a key role in fatty acid oxidation and biosynthesis.. palmitoyl-CoA : A long-chain fatty acyl-CoA resulting from the formal condensation of the carboxy group of hexadecanoic acid with the thiol group of coenzyme A.	1.99	1	11,12-saturated fatty acyl-CoA; 3-substituted propionyl-CoA; long-chain fatty acyl-CoA; palmitoyl bioconjugate	Escherichia coli metabolite; mouse metabolite
3-methylhexadecanoic acid 3-methylhexadecanoic acid: see also cpd with unspecified methyl position: 112-39-0	1.96	1	long-chain fatty acid
quinine [no description available]	1.97	1	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic

Condition	Relationship Strength	Studies
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.96	1
Adrenoleukodystrophy, Autosomal Neonatal Form [description not available]	2	1
Malabsorption Syndromes General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.	2	1
Deficiency, Vitamin K [description not available]	2	1
Vitamin K Deficiency A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)	2	1
Peroxisomal Disorders A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders.	2	1

2-methylhexadecanoic acid

Description

Cross-References

Synonyms (26)

Research Excerpts

Pharmacokinetics

Drug Classes (3)

Research

Studies (11)

Market Indicators

Research Demand Index: 12.17

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