Compounds > 2-methyl-1,2-epoxypropane
Page last updated: 2024-12-05

2-methyl-1,2-epoxypropane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Methyl-1,2-epoxypropane, also known as propylene oxide, is a colorless liquid with a sweet odor. It is an important industrial chemical, used in the production of polymers, polyols, and other chemicals. Propylene oxide is synthesized by the oxidation of propylene with air or oxygen in the presence of a silver catalyst. It is also a versatile reagent used in organic synthesis, and is an intermediate in the production of several other compounds. Propylene oxide is classified as a flammable liquid and a respiratory irritant. It is also known to be mutagenic and potentially carcinogenic. Research into propylene oxide focuses on its safety, environmental impact, and potential applications in various fields. It's toxicological properties, particularly its ability to act as a mutagen, have led to concerns about its safety, prompting further research and development of safer alternatives. Understanding the chemical properties and potential hazards of propylene oxide is crucial for its safe handling, storage, and use. Studies continue to examine its potential environmental impact, including its degradation and persistence in the environment. '

2-methyl-1,2-epoxypropane: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11208
CHEBI ID193943
MeSH IDM0194201

Synonyms (56)

Synonym
uj14mj1wg0 ,
5-17-01-00058 (beilstein handbook reference)
unii-uj14mj1wg0
ec 209-193-8
oxirane, 2,2-dimethyl-
nsc24249
2,2-dimethyloxirane
isobutylene oxide
propane,2-epoxy-2-methyl-
2-methyl-1,2-epoxypropane
2-methyl-1-propene oxide
1,1-dimethylethylene oxide
oxirane,2-dimethyl-
nsc-24249
1,2-epoxy-2-methylpropane
558-30-5
isobutene oxide
isobutylene epoxide
1,2-isobutylene oxide
einecs 209-193-8
1,2-epoxyisobutane
nsc 24249
ccris 4380
propane, 1,2-epoxy-2-methyl-
brn 0102408
isobutyleneoxide
1,2-epoxy-2-methylpropane, 97%
gelkghvafrcjna-uhfffaoysa-
inchi=1/c4h8o/c1-4(2)3-5-4/h3h2,1-2h3
2-methylpropylene oxide
I0323
CHEBI:193943
AKOS009157227
1,2-epoxy-isobutane
1,1-dimethyloxirane
A830830
FT-0606466
isobutylenoxide
2,2-dimethyloxiran
2,2-dimethyl oxirane
2,2-dimethyl-oxirane
1,2-epoxy-2-methyl-propane
2, 2-dimethyloxirane
DTXSID7060330
W-109563
mfcd00066354
2-methyl-1, 2-epoxypropane
1, 1-dimethylethylene oxide
1, 2-isobutylene oxide
1,2-epoxy-2-methylpropane, 8ci
ethylene oxide, .alpha.,.alpha.-dimethyl-
methyl-1,2-epoxypropane, 2-
ccris-4380
2-methyl-1-propenoxide
EN300-36458
25068-10-4

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" MP is thus not toxic per se but elicits metabolic activation to become potentially harmful."( Metabolism and toxicity of 2-methylpropene (isobutene)--a review.
Cornet, M; Rogiers, V, 1997)		0.3

Dosage Studied

ExcerptRelevanceReference
" MEP is mutagenic in all the strains tested, as demonstrated by a clear dose-response relationship."( Mutagenicity of 2-methylpropene (isobutene) and its epoxide in a modified Salmonella assay for volatile compounds.
Castelain, P; Cornet, M; Kirsch-Volders, M; Laib, R; Rogiers, V; Vercruysse, A, 1992)		0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
epoxideAny cyclic ether in which the oxygen atom forms part of a 3-membered ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
2-methylpropene degradation018

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (50.00)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.41 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		2.110aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
propylene oxide
propylene oxide: structure. 1,2-epoxypropane : An epoxide that is oxirane substituted by a methyl group at position 2.		6.9810epoxide
triethylene glycol dimethacrylate
[no description available]		2.110
vinyl ether
vinyl ether: major descriptor (65-85); on-line search VINYL COMPOUNDS (66-85); Index Medicus search VINYL ETHER (65-85)		2.0810ether
isobutylene
2-methylprop-1-ene : An alkene that is prop-1-ene substituted by a methyl group at position 2.		440alkene;
gas molecular entity
alkenes
[no description available]		440
1,10-decanediol
[no description available]		2.110
methacryloyloxydecyl dihydrogen phosphate
methacryloyloxydecyl dihydrogen phosphate: structure given in first source		2.110
1,12-dodecanediol dimethacrylate
1,12-dodecanediol dimethacrylate: structure in first source		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0410