Compounds > 2-furoic acid hydrazide
Page last updated: 2024-11-05

2-furoic acid hydrazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Furoic acid hydrazide (FAH) is a heterocyclic compound with a variety of biological activities. It has been studied for its potential as an antimicrobial, anti-inflammatory, and anti-cancer agent. FAH can be synthesized through the reaction of 2-furoic acid with hydrazine hydrate. It exhibits anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines like TNF-alpha and IL-6. Its anticancer activity is attributed to its ability to induce apoptosis in cancer cells. FAH also possesses antimicrobial properties, inhibiting the growth of bacteria and fungi. Its broad spectrum of biological activities makes it a promising candidate for drug development in various therapeutic areas.'
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2-furoylhydrazine: used for determination of carbohydrates [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID18731
CHEMBL ID340492
SCHEMBL ID140989
MeSH IDM0078011

Synonyms (61)

Synonym
HMS1775C18
nsc35574
nsc-35574
pyromucic acid hydrazide
nsc 35574
2-furoic acid hydrazide
einecs 222-046-2
2-furancarbohydrazide
nsc 11957
2-furoic hydrazide
2-furancarbonyl hydrazide
ai3-62534
brn 0114435
wln: t5oj bvmz
nsc11957
3326-71-4
2-furylcarbonylhydrazide
2-furoic acid, hydrazide
2-furoylhydrazide
furoylhydrazide
2-furylcarboxylic acid hydrazide
2-furancarbohydrazonic acid
2-furancarboxylic acid, hydrazide
furoic acid, hydrazide
nsc-11957
AN-068/40170015
2-furohydrazide
furan-2-carbohydrazide
inchi=1/c5h6n2o2/c6-7-5(8)4-2-1-3-9-4/h1-3h,6h2,(h,7,8
2-furoic hydrazide, 98%
STK121925
2-furoylhydrazine
AKOS000194881
furan-2-carboxylic acid hydrazide
CHEMBL340492
5-18-06-00125 (beilstein handbook reference)
A821702
FT-0634781
2-furancarboxylic acid hydrazide
CS-M1764
2-furanoic hydrazide
2-furanhydrazide
furan 2-carbohydrazide
SCHEMBL140989
2-furoicacidhydrazide
F3145-4915
furancarboxylic acid, hydrazide
J-521392
DTXSID10186900
mfcd00003235
2-furoic hydrazide, purum, >=97.0% (nt)
AS-57679
J-019120
2-furancarboxylic acid,hydrazide
Z57036326
SY048471
F10405
F1015
AM10044
2-furoichydrazide
EN300-17784
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1059231Antitubercular activity against Mycobacterium tuberculosis2013European journal of medicinal chemistry, , Volume: 70Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
AID1059234Lipophilicity, log P of the compound2013European journal of medicinal chemistry, , Volume: 70Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
AID143262Minimum inhibitory concentration against Mycobacterium tuberculosis var. bovis strain at 310K, with value expressed as pMIC i.e. -log of MIC (ug/mL).2004Journal of medicinal chemistry, Jul-15, Volume: 47, Issue:15
Rational design of new antituberculosis agents: receptor-independent four-dimensional quantitative structure-activity relationship analysis of a set of isoniazid derivatives.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.53 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index24.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid hydrazide
4-hydroxybenzoic acid hydrazide: metabolite of nifuroxazide. 4-hydroxybenzohydrazide : A carbohydrazide obtained by formal condensation of the carboxy group of 4-hydroxybenzoic acid with hydrazine.		2.6930carbohydrazide;
phenols
iproniazid
[no description available]		2.0810carbohydrazide;
pyridines
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.4520carbohydrazideantitubercular agent;
drug allergen
hydrazine
diamine : Any polyamine that contains two amino groups.		1.9610azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
nicotinic acid hydrazide
nicotinic acid hydrazide: structural homolog of isoniazid; structure given in first source		2.4520
benzoylhydrazine
benzoylhydrazine: inhibits copper-depleted bovine serum amine oxidase		2.4520carbohydrazide
acetylhydrazine
acetylhydrazine: metabolite of isoniazid in animals and humans; RN given refers to parent cpd. acetohydrazide : A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.		2.0810carbohydrazide;
carbohydrazonic acid		drug metabolite
fructosamine
Fructosamine: An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the classical Amadori rearrangement.		1.9610
4-aminobenzhydrazide
4-aminobenzhydrazide: a Russian synthetic drug of acylhydrazide group; decreased uterus wt in rats; RN given refers to cpd with specified locants for amino group		2.0810
acetylisoniazid
acetylisoniazid: Antitubercular Agent. N'-acetylisoniazid : A carbohydrazide resulting from the formal condensation of the carboxy group of isonicotinic acid with hydrazine and subsequent acetylation of the monosubstituted nitrogen atom.		2.0810carbohydrazidemetabolite
succinic dihydrazide
succinic dihydrazide: structure given in first source		2.0810
n,n'-diacetylhydrazine
[no description available]		2.0810carbohydrazide
thiophene-2-carboxylic acid hydrazide
thiophene-2-carbohydrazide: structure in first source		2.0810
4-methoxybenzohydrazide
4-methoxybenzohydrazide: structure in first source		2.0810
3-nitrobenzhydrazide
[no description available]		2.4520
bismuth
Bismuth: A metallic element that has the atomic symbol Bi, and atomic number 83. Its principal isotope is Bismuth 209.		1.9610metal atom;
pnictogen
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610