Compounds > 2-ethylphenyl 4-(3-ethylureido)benzenesulfonate
Page last updated: 2024-11-13

2-ethylphenyl 4-(3-ethylureido)benzenesulfonate

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Description

2-ethylphenyl 4-(3-ethylureido)benzenesulfonate: has antineoplastic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID60168106
CHEMBL ID2165736
SCHEMBL ID13723193
MeSH IDM0577534

Synonyms (7)

Synonym
CHEMBL2165736 ,
SCHEMBL13723193
2-ethylphenyl 4-(3-ethylureido)benzenesulfonate
bdbm50559136
sfom-0046
1383607-61-1
AKOS040749490
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)IC50 (µMol)0.07200.00050.742710.0000AID1718010
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (4)

Processvia Protein(s)Taxonomy
UDP biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
'de novo' UMP biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
pyrimidine ribonucleotide biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
'de novo' pyrimidine nucleobase biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
dihydroorotase activityDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
protein bindingDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
dihydroorotate dehydrogenase (quinone) activityDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
dihydroorotate dehydrogenase activityDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleoplasmDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
mitochondrionDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
mitochondrial inner membraneDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
cytosolDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
mitochondrial inner membraneDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (82)

Assay IDTitleYearJournalArticle
AID1718034Antiproliferative activity against human KM12 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718063Antiproliferative activity against human OVCAR-8 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718069Antiproliferative activity against human T47D cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718058Antiproliferative activity against human UACC-62 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID697162Cell cycle arrest in human Jurkat E6-1 cells assessed as accumulation at G0/G1 phase at 2.2 uM after 24 hrs by FACS flow cytometry2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718074Antiproliferative activity against human Panel NCI-60 (60 carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718010Inhibition of recombinant N-terminal His-tagged human DHODH (31 to 395 residues) expressed in Escherichia coli using L-DHO as substrate measured every 10 mins for 90 mins in presence of decylubiquinone by DCIP based colorimetric assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718035Antiproliferative activity against human SW-620 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718021Antiproliferative activity against human SR cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1255452Antiproliferative activity against human HT-29 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B.
AID1718039Antiproliferative activity against human CAKI-1 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718047Antiproliferative activity against human SNB-19 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718027Antiproliferative activity against human NCI-H322M cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718008Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718068Antiproliferative activity against human BT-549 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID697202Cell cycle arrest in human Jurkat E6-1 cells assessed as accumulation at S phase at 2.2 uM after 24 hrs by FACS flow cytometry2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718022Antiproliferative activity against human A549/ATCC cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718072Antiproliferative activity against human Panel leukemia (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718042Antiproliferative activity against human TK-10 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718018Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718037Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718070Antiproliferative activity against human PC-3 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718065Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718057Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718016Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718073Antiproliferative activity against human Panel colon (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID697448Cell cycle arrest in human Jurkat E6-1 cells assessed as accumulation at G2/M phase at 2.2 uM after 24 hrs by FACS flow cytometry2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718029Antiproliferative activity against human NCI-H522 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718032Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718059Antiproliferative activity against human IGROV-1 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718071Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718019Antiproliferative activity against human MOLT-4 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718013Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718028Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718066Antiproliferative activity against human MDA-MB-231/ATCC cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718011Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718038Antiproliferative activity against human ACHN cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718024Antiproliferative activity against human HOP-92 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718055Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1405136Alkylating activity at DNA (unknown origin) after 90 mins by colorimetric NBP assay2018European journal of medicinal chemistry, Jul-15, Volume: 155Preparation, characterisation and biological evaluation of new N-phenyl amidobenzenesulfonates and N-phenyl ureidobenzenesulfonates inducing DNA double-strand breaks. Part 3. Modulation of ring A.
AID1255453Antiproliferative activity against human MCF7 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B.
AID1718020Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID697456Induction of DNA damage response in human M21 cells assessed as phosphorylation of H2AX into gammaH2AX at IC50 after 24 hrs by DAPI staining-based immunofluorescence assay2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718026Antiproliferative activity against human NCI-H23 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718056Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718045Antiproliferative activity against human SF-295 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718064Antiproliferative activity against human NCI/ADR-RES cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718025Antiproliferative activity against human NCI-H226 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID700195Cytotoxicity against human HT-29 cells after 48 hrs by SRB assay2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID700196Cytotoxicity against human M21 cells after 48 hrs by SRB assay2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718061Antiproliferative activity against human OVCAR-4 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718048Antiproliferative activity against human SNB-75 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718049Antiproliferative activity against human U-251 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718053Antiproliferative activity against human MDA-MB-435 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718036Antiproliferative activity against human 786-0 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718054Antiproliferative activity against human SK-MEL-2 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718052Antiproliferative activity against human M14 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718044Antiproliferative activity against human SF-268 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID697462Toxicity in fertilized chicken embryo assessed as mortality rate at 30 ug per egg, iv administered on day 11 measured on day 17 by CAM assay2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718030Antiproliferative activity against human COLO 205 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1405137Alkylating activity at DNA (unknown origin) after 90 mins by colorimetric NBP assay relative to chlorambucil2018European journal of medicinal chemistry, Jul-15, Volume: 155Preparation, characterisation and biological evaluation of new N-phenyl amidobenzenesulfonates and N-phenyl ureidobenzenesulfonates inducing DNA double-strand breaks. Part 3. Modulation of ring A.
AID1718014Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718040Antiproliferative activity against human RXF 393 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718023Antiproliferative activity against human HOP-62 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID700197Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718015Antiproliferative activity against human HT-1080 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718067Antiproliferative activity against human Hs-578T cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718009Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718012Antiproliferative activity against human M21 cells assessed as cell growth inhibition measured after 48 hrs in presence of uridine by SRB assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID697459Antitumor activity against human HT1080 cells xenografted in chicken chorioallantoic membrane assessed as inhibition of tumor growth at 30 ug per egg, iv administered on day 11 measured on day 17 by CAM assay2012Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.
AID1718041Antiproliferative activity against human SN12C cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718017Antiproliferative activity against human CCRF-CEM cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718033Antiproliferative activity against human HCT-15 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718051Antiproliferative activity against human Malme-3M cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718050Antiproliferative activity against human LOX IMVI cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718031Antiproliferative activity against human HCC 2998 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1255451Antiproliferative activity against human M21 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B.
AID1718060Antiproliferative activity against human OVCAR-3 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718062Antiproliferative activity against human OVCAR-5 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1255450Antiproliferative activity against human HT1080 cells assessed as growth inhibition incubated for 48 hrs by sulforhodamine B assay2015European journal of medicinal chemistry, Oct-20, Volume: 103Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B.
AID1718043Antiproliferative activity against human UO-31 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
AID1718046Antiproliferative activity against human SF-539 cells assessed as cell growth inhibition measured after 48 hrs by sulforhodamine B assay2020Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
N-phenyl ureidobenzenesulfonates, a novel class of promising human dihydroorotate dehydrogenase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorambucil
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed). chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.		2.1710aromatic amine;
monocarboxylic acid;
nitrogen mustard;
organochlorine compound;
tertiary amino compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
leflunomide
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.. leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.		2.2510(trifluoromethyl)benzenes;
isoxazoles;
monocarboxylic acid amide		antineoplastic agent;
antiparasitic agent;
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
hepatotoxic agent;
immunosuppressive agent;
non-steroidal anti-inflammatory drug;
prodrug;
pyrimidine synthesis inhibitor;
tyrosine kinase inhibitor
brequinar
brequinar : A quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties.		2.2510biphenyls;
monocarboxylic acid;
monofluorobenzenes;
quinolinemonocarboxylic acid		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral agent;
EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor;
immunosuppressive agent;
pyrimidine synthesis inhibitor
topotecan
Topotecan: An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.. topotecan : A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.		2.5420pyranoindolizinoquinolineantineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor
imidazolidines
[no description available]		2.0710azacycloalkane;
imidazolidines;
saturated organic heteromonocyclic parent
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.0710stilbene
fosbretabulin
[no description available]		2.0710stilbenoid
fosbretabulin
fosbretabulin: a microtubule destabilizing agent isolated from Combretum caffrum; structure in first source		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0710
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0710