2-chlorotrityl chloride

Description

2-Chlorotrityl chloride is a widely used solid-phase resin for the synthesis of peptides and other organic molecules. It is a highly reactive compound that forms a stable bond with the N-terminus of an amino acid, allowing for the stepwise addition of amino acids to build up a peptide chain. The compound is typically synthesized by reacting trityl chloride with chlorine gas in the presence of a Lewis acid catalyst. The resulting 2-chlorotrityl chloride is then attached to a solid support, such as polystyrene beads. The synthesis of peptides using 2-chlorotrityl chloride involves a series of steps, including: 1) Deprotection of the N-terminus of the first amino acid, 2) Coupling of the first amino acid to the resin, 3) Deprotection of the N-terminus of the second amino acid, 4) Coupling of the second amino acid to the first, 5) Repeated deprotection and coupling steps to add the remaining amino acids, and 6) Cleavage of the peptide from the resin. 2-Chlorotrityl chloride is an important tool for the synthesis of peptides, as it allows for the efficient and reliable production of a wide range of peptides. The compound is also used in the synthesis of other organic molecules, such as oligonucleotides and carbohydrates. The synthesis of peptides and other organic molecules using 2-chlorotrityl chloride is a complex process that requires careful optimization of the reaction conditions. However, this method offers several advantages over traditional solution-phase synthesis, including: 1) Higher yields, 2) Reduced purification steps, 3) Greater control over the reaction conditions, and 4) Increased reproducibility. This method is widely studied and used in the pharmaceutical industry, as it allows for the rapid and efficient production of a wide range of peptides and other organic molecules.'

2-chlorotrityl chloride: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]