Compounds > 2-chloropyrimidine
Page last updated: 2024-11-06

2-chloropyrimidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Chloropyrimidine is a heterocyclic compound that is used as a building block in organic synthesis. It can be synthesized via the chlorination of pyrimidine using phosphorus oxychloride. 2-Chloropyrimidine is a versatile intermediate for the preparation of various pyrimidine derivatives. It is used as a starting material for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Research on 2-Chloropyrimidine is important because of its potential applications in medicinal chemistry and materials science. For instance, 2-Chloropyrimidine has been investigated as a potential scaffold for the development of new drugs for the treatment of various diseases, such as cancer and malaria. Furthermore, its reactivity allows for the formation of diverse functionalized pyrimidine derivatives with unique electronic and optical properties. Therefore, the study of 2-Chloropyrimidine and its derivatives is crucial for exploring new applications in various fields.'

2-chloropyrimidine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID74404
SCHEMBL ID27503
MeSH IDM0538216

Synonyms (39)

Synonym
AC-2505
2-chloro-pyrimidine
nsc 43544
einecs 217-020-2
pyrimidine, 2-chloro-
1722-12-9
nsc-43544
nsc43544
inchi=1/c4h3cln2/c5-4-6-2-1-3-7-4/h1-3
2-chloro-4-deoxyuracil
2-chloropyrimidine
2-chloropyrimidine, 95%
C1050
STK803251
AKOS000120420
chloropyrimidine
2-chloro-pyrimindine
AM803332
BP-13180
FT-0604347
AB00572
SCHEMBL27503
2-chloropyrirnidine
2-pyrimidinyl chloride
2-chloro pyrimidine
2chloropyrimidine
chloro-pyrimidine
2-chloropyrimidin
STR00974
Q-101431
mfcd00006060
DTXSID70169214
CS-W008600
Z104477694
94EZW2WL9E
BCP26378
buspirone intermediates
EN300-20306
BB 0294772
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.96 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index47.89 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.2110catechinantioxidant;
plant metabolite
pyrimidine
pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.		1.9210diazine;
pyrimidines		Daphnia magna metabolite
pyrazines
Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.		2.0510diazine;
pyrazines		Daphnia magna metabolite
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.2110flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
metachloridine
metachloridine: structure		1.9210
2-chloropyrazine
2-chloropyrazine: structure in first source		7.0510pyrazines
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		7.0510cobalt group element atom;
metal allergen		micronutrient
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		01.9210
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		01.9210