Compounds > 2-chloroethyl methanesulfonate
Page last updated: 2024-12-06

2-chloroethyl methanesulfonate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID19128
CHEMBL ID275438
SCHEMBL ID2734239
MeSH IDM0255077

Synonyms (39)

Synonym
chloroethyl methanesulfonate
ethanol, 2-chloro-, methanesulfonate
methanesulfonic acid, chloroethyl ester
2-chloroethyl methanesulphonate
einecs 222-672-6
beta-chloroethylmethanesulfonate
ai3-26395
chloroethyl methanesulphonate
brn 1754022
wln: ws1&o2g
nsc18016
methanesulfonic acid, 2-chloroethyl ester
3570-58-9
.beta.-chloroethylmethanesulfonate
nsc 18016
2-chloroethylmethanesulfonate
cb 1506
2-chloroethylmethanesulfonate, puriss
nsc-18016
2-chloroethyl methanesulfonate
2-chloroethyl methanesulfonate, >=99%
methanesulfonic acid 2-chloroethyl ester
C2231
methanesulfonic acid 2-chloro-ethyl ester
CHEMBL275438
AKOS006222794
unii-895h18q125
895h18q125 ,
FT-0634908
SCHEMBL2734239
2-chloroethyl mesylate
DTXSID20189220
mfcd00007560
BS-16652
H11355
Q27269999
CS-W013279
chloroethyl mesylate
SY051715
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID154836Mortality of P388 leukemia in mice at a dose of 100 mg/kg, schedule (q.d.)).1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154062T/C ratio against P388 leukemia in mice at at a dose(mg/kg, schedule (q.d.))1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154059T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.))1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154699weight change difference (T-C) in mice against P388 leukemia at a dose(mg/kg, schedule)1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154061T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule)1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID227561Compound was evaluated for its ability to exhibit alkylating property toward DNA at 5 mM in 180 min1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Noval antitumor nitrosoureas and related compounds and their reactions with DNA.
AID154060T/C ratio against P388 leukemia in mice at a dose(mg/kg, schedule (q.d.).1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154552Survival time(T/C) of mice against P388 leukemia at a dose of 400 mg/kg, schedule (q.d.); ND means no data1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154698Weight change in mice against P388 leukemia1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154541Survival time(T/C) of mice against P388 leukemia at a dose of 200 mg/kg, schedule (q.d.); ND means no data1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154519Survival time(T/C) of mice against P388 leukemia at a dose of 100 mg/kg, schedule (q.d.); 15.3 treated by 11.4 control1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154985Mortality of P388 leukemia in mice at a dose of 400 mg/kg, schedule (q.d.)); 6 mice dead out of 6 treated mice1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154977Mortality of P388 leukemia in mice at a dose of 200 mg/kg, schedule (q.d.)); 5 mice dead out of 6 treated mice1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154537Survival time(T/C) of mice against P388 leukemia at a dose of 200 mg/kg, schedule (q.d.); 13.1 treated by 11.9 control1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154063T/C ratio against P388 leukemia in mice dose(mg/kg, schedule (q.d.))1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154848Mortality of P388 leukemia in mice at a dose of 200 mg/kg, schedule (q.d.)); 1 mice dead out of 6 treated mice1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154691Survival time(T/C) of mice against P388 leukemia at a dose of 50 mg/kg, schedule (q.d.); Toxic1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
AID154987Mortality of P388 leukemia in mice at a dose of 50 mg/kg, schedule (q.d.)); 0 mice dead out of 6 treated mice1983Journal of medicinal chemistry, Aug, Volume: 26, Issue:8
2-haloethylating agents for cancer chemotherapy. 2-haloethyl sulfonates.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19909 (90.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.88 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethylene dichloride
ethylene dichloride: RN given refers to 1,2-isomer; structure given in first source. 1,2-dichloroethane : A member of the class of chloroethanes substituted by two chloro groups at positions 1 and 2.		1.9810chloroethaneshepatotoxic agent;
mutagen;
non-polar solvent
mechlorethamine
nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.		1.9310nitrogen mustard;
organochlorine compound		alkylating agent
ethyl methanesulfonate
Ethyl Methanesulfonate: An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect.. ethyl methanesulfonate : A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol.		1.9310methanesulfonate esteralkylating agent;
antineoplastic agent;
carcinogenic agent;
genotoxin;
mutagen;
teratogenic agent
phenylalanine
Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.		6.9310amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid		algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
methanesulfonic acid
[no description available]		2.3420alkanesulfonic acid;
one-carbon compound		Escherichia coli metabolite
ethylene dibromide
Ethylene Dibromide: An effective soil fumigant, insecticide, and nematocide. In humans, it causes severe burning of skin and irritation of the eyes and respiratory tract. Prolonged inhalation may cause liver necrosis. It is also used in gasoline. Members of this group have caused liver and lung cancers in rodents. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), 1,2-dibromoethane may reasonably be anticipated to be a carcinogen.. 1,2-dibromoethane : A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae.		1.9810bromoalkane;
bromohydrocarbon		algal metabolite;
carcinogenic agent;
fumigant;
marine metabolite;
mouse metabolite;
mutagen
ethylnitrosourea
Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.		1.9510N-nitrosoureasalkylating agent;
carcinogenic agent;
genotoxin;
mutagen
n-(2-chloroethyl)-n-nitrosoacetamide
N-(2-chloroethyl)-N-nitrosoacetamide: structure given in first source		1.9510
1-(2-chloroethyl)-1-nitrosourea
[no description available]		1.9510
melphalan
Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.		6.9310L-phenylalanine derivative;
nitrogen mustard;
non-proteinogenic L-alpha-amino acid;
organochlorine compound		alkylating agent;
antineoplastic agent;
carcinogenic agent;
drug allergen;
immunosuppressive agent
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia L 1210
[description not available]		02.3620
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9610