Page last updated: 2024-11-13

2-chloro-6-(3-methoxyphenyl)aminopurine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-chloro-6-(3-methoxyphenyl)aminopurine: inhibits cytokine degradation; inhibits AtCKX2 protein [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21988300
CHEMBL ID484383
SCHEMBL ID3004036
MeSH IDM0584352

Synonyms (10)

Synonym
bdbm50274549
2-chloro-6-(3-methoxyanilino)purine
CHEMBL484383 ,
VEMDTFVUDJLJKF-UHFFFAOYSA-N
190654-89-8
SCHEMBL3004036
c12h10cln5o
2-chloro-6-(3-methoxyphenyl)aminopurine
2-chloro-n-(3-methoxyphenyl)-7h-purin-6-amine
EN300-252845
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytokinin dehydrogenase 2Arabidopsis thaliana (thale cress)IC50 (µMol)1.90001.90001.90001.9000AID389123
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Histidine kinase 4Arabidopsis thaliana (thale cress)EC50 (µMol)7.00001.00003.03337.0000AID389121
Histidine kinase 3Arabidopsis thaliana (thale cress)EC50 (µMol)21.00000.70000.82500.9500AID389122
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID389131Cytokinin-like effect in wheat assessed as retention of chlorophyll in excised leaves at 100 umol/L by senescence assay relative to 6-benzylaminopurine2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
AID389125Cytokinin-like effect in tobacco assessed as stimulation of callus growth at 10 umol/L relative to 6-benzylaminopurine2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
AID389121Activation of Arabidopsis thaliana AHK4/CRE1 receptor expressed in Escherichia coli KMI001 by beta-galactosidase activity2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
AID389122Activation of Arabidopsis thaliana AHK3 receptor expressed in Escherichia coli KMI001 by beta-galactosidase activity2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
AID389123Inhibition of sArabidopsis thaliana CKX2 expressed in Saccharomyces cerevisiae 23344c ura-2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
AID389128Cytokinin-like effect in Amaranthus cotyledons assessed as dark induction of betacyanin synthesis at 100 umol/L relative to 6-benzylaminopurine2008Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.26 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]