2-chloro-6-(3-methoxyphenyl)aminopurine: inhibits cytokine degradation; inhibits AtCKX2 protein
ID Source | ID |
---|---|
PubMed CID | 21988300 |
CHEMBL ID | 484383 |
SCHEMBL ID | 3004036 |
MeSH ID | M0584352 |
Synonym |
---|
bdbm50274549 |
2-chloro-6-(3-methoxyanilino)purine |
CHEMBL484383 , |
VEMDTFVUDJLJKF-UHFFFAOYSA-N |
190654-89-8 |
SCHEMBL3004036 |
c12h10cln5o |
2-chloro-6-(3-methoxyphenyl)aminopurine |
2-chloro-n-(3-methoxyphenyl)-7h-purin-6-amine |
EN300-252845 |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Cytokinin dehydrogenase 2 | Arabidopsis thaliana (thale cress) | IC50 (µMol) | 1.9000 | 1.9000 | 1.9000 | 1.9000 | AID389123 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Histidine kinase 4 | Arabidopsis thaliana (thale cress) | EC50 (µMol) | 7.0000 | 1.0000 | 3.0333 | 7.0000 | AID389121 |
Histidine kinase 3 | Arabidopsis thaliana (thale cress) | EC50 (µMol) | 21.0000 | 0.7000 | 0.8250 | 0.9500 | AID389122 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID389131 | Cytokinin-like effect in wheat assessed as retention of chlorophyll in excised leaves at 100 umol/L by senescence assay relative to 6-benzylaminopurine | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20 | Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase. |
AID389125 | Cytokinin-like effect in tobacco assessed as stimulation of callus growth at 10 umol/L relative to 6-benzylaminopurine | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20 | Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase. |
AID389121 | Activation of Arabidopsis thaliana AHK4/CRE1 receptor expressed in Escherichia coli KMI001 by beta-galactosidase activity | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20 | Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase. |
AID389122 | Activation of Arabidopsis thaliana AHK3 receptor expressed in Escherichia coli KMI001 by beta-galactosidase activity | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20 | Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase. |
AID389123 | Inhibition of sArabidopsis thaliana CKX2 expressed in Saccharomyces cerevisiae 23344c ura- | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20 | Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase. |
AID389128 | Cytokinin-like effect in Amaranthus cotyledons assessed as dark induction of betacyanin synthesis at 100 umol/L relative to 6-benzylaminopurine | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20 | Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 4 (66.67) | 24.3611 |
2020's | 1 (16.67) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.26) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |