Compounds > 2-chloro-4-nitroaniline
Page last updated: 2024-12-05

2-chloro-4-nitroaniline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-chloro-4-nitroaniline: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8492
CHEMBL ID1893710
SCHEMBL ID532698
SCHEMBL ID15630259
MeSH IDM0193948

Synonyms (59)

Synonym
einecs 204-502-2
ortho-chloro-para-nitroaniline
ccris 2648
brn 0638657
hsdb 5405
nsc 3548
ai3-09084
ocpna
nsc-3548
aniline, 2-chloro-4-nitro-
1-amino-2-chloro-4-nitrobenzene
4-nitro-2-chloroaniline
nsc3548
2-chloro-4-nitrobenzenamine
benzenamine, 2-chloro-4-nitro-
o-chloro-p-nitroaniline
121-87-9
2-chloro-4-nitroaniline
wln: zr bg dnw
inchi=1/c6h5cln2o2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3h,8h
STK358782
2-chloro-4-nitroaniline, 99%
NCGC00164027-01
AC-7419
2-chloro-4-nitro-phenylamine
AKOS000120340
A804801
2-chloranyl-4-nitro-aniline
(2-chloro-4-nitro-phenyl)-amine
unii-xsa3zx337b
xsa3zx337b ,
4-12-00-01675 (beilstein handbook reference)
2-chloro-4-nitrophenylamine
FT-0611787
AM20060498
AE-562/40244765
SCHEMBL532698
chloro-4-nitroaniline, 2-
1-amino-2-chloro-4-nitrobenzene [hsdb]
2-chloro-4-nitro-aniline
2-chlor-4-nitroanilin
dtxcid201973
dtxsid4021973 ,
tox21_303921
cas-121-87-9
NCGC00357167-01
CHEMBL1893710
SCHEMBL15630259
BS-3940
CS-W020588
J-508775
F0001-0350
mfcd00007665
(2-chloro-4-nitrophenyl)amine
Z57126995
2-chloro-4-nitroaniline,(s)
Q2597946
EN300-17939
D88095

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The results are discussed with respect to the physiology of the organisms and the bioavailability of toxicants, as well as to the consequences these results may have under field conditions."( The influence of suspended particles on the acute toxicity of 2-chloro-4-nitro-aniline, cadmium, and pentachlorophenol on the valve movement response of the zebra mussel (Dreissena polymorpha).
Borcherding, J; Wolf, J, 2001)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency89.35840.007215.758889.3584AID1224835
AR proteinHomo sapiens (human)Potency29.18920.000221.22318,912.5098AID1259243; AID1259247; AID588516
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency44.69250.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency54.48270.000417.946075.1148AID1346795
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.61130.001530.607315,848.9004AID1224841
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency19.95260.001019.414170.9645AID588537
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.66 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index41.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pentachlorophenol
PENTA: structure given in first source		710aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes		human xenobiotic metabolite
2,2'-dipyridyl
2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.		2.0810bipyridinechelator;
ferroptosis inhibitor
2,5-dihydroxybenzoic acid
2,5-dihydroxybenzoic acid: RN given refers to parent cpd; a oxidative product of saligenin. 2,5-dihydroxybenzoic acid : A dihydroxybenzoic acid having the two hydroxy groups at the 2- and 5-positions.		2.2110dihydroxybenzoic acidEC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
fungal metabolite;
human metabolite;
MALDI matrix material;
mouse metabolite
niclosamide
Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.		7.4420benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide		anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor
aniline
[no description available]		2.1310anilines;
primary arylamine
4-nitroaniline
[no description available]		2.1310nitroanilinebacterial xenobiotic metabolite
5-chlorosalicylic acid
5-chlorosalicylic acid: major metabolite of meseclazone; RN given refers to parent cpd. 5-chlorosalicylic acid : A monohydroxybenzoic acid that is 2-hydroxybenzoic acid (salicylic acid) in which the hydrogen at position 5 is replaced by chlorine.		6.9710chlorobenzoic acid;
monochlorobenzenes;
monohydroxybenzoic acid
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		710cadmium molecular entity;
zinc group element atom
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		1.9710monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials