Compounds > 2-carboxythiazolidine-4-carboxylic acid
Page last updated: 2024-12-06

2-carboxythiazolidine-4-carboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-carboxythiazolidine-4-carboxylic acid: hepatoprotective drug; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72150
CHEMBL ID2064047
CHEBI ID134811
SCHEMBL ID868048
MeSH IDM0173304

Synonyms (41)

Synonym
tidiacic
CHEBI:134811
inchi=1/c5h7no4s/c7-4(8)2-1-11-3(6-2)5(9)10/h2-3,6h,1h2,(h,7,8)(h,9,10)
daxbisksidbyeu-uhfffaoysa-
1,3-thiazolidine-2,4-dicarboxylic acid
2,4-thiazolidinedicarboxylic acid
AKOS005070257
30097-06-4
thiazolidine-2,4-dicarboxylic acid
T1325
tetrahydrothiazole-2,4-dicarboxylic acid
tidiacic acid
CHEMBL2064047
f39kss6r80 ,
tidiacicum [inn-latin]
tidiacico [inn-spanish]
tidiacico
einecs 250-048-3
2-carboxythiazolidine-4-carboxylic acid
tidiacic [inn:dcf]
tidiacicum
unii-f39kss6r80
FT-0680287
3J-939
1,3-thiazolane-2,4-dicarboxylic acid
SCHEMBL868048
NCGC00253712-01
1,3-thiazolidine-2,4-dicarboxylic acid #
c5h7no4s
J-524916
1,3-thiazolidine-2,4-dicarboxylic acid, aldrichcpr
mfcd00145399
sr-01000944861
SR-01000944861-1
Q7800905
DTXSID30865528
CS-0060752
W17240
A853749
HY-W024241
SY051124
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
organooxygen compoundAn organochalcogen compound containing at least one carbon-oxygen bond.
organonitrogen compoundAny heteroorganic entity containing at least one carbon-nitrogen bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (11)

Assay IDTitleYearJournalArticle
AID674672Competitive inhibition of CcrA using cezafolin as substrate incubated for 30 mins prior to substrate addition by Lineweaver-burk plot analysis2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674684Inhibition of metallo-beta-lactamase in methicillin-resistant Staphylococcus aureus isolate 1 assessed as reduction in cefazolin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674686Inhibition of metallo-beta-lactamase in methicillin-resistant Staphylococcus aureus isolate 2 assessed as reduction in cefazolin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674685Inhibition of metallo-beta-lactamase in methicillin-resistant Staphylococcus aureus isolate 1 assessed as reduction in vancomycin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674682Inhibition of L1 in Escherichia coli BL21(DE3) assessed as reduction in cefazolin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674675Competitive inhibition of ImiS using cezafolin as substrate incubated for 30 mins prior to substrate addition by Lineweaver-burk plot analysis2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674687Inhibition of metallo-beta-lactamase in methicillin-resistant Staphylococcus aureus isolate 2 assessed as reduction in vancomycin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674680Inhibition of CcrA in Escherichia coli BL21(DE3) assessed as reduction in cefazolin MIC for after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674678Competitive inhibition of L1 using cezafolin as substrate incubated for 30 mins prior to substrate addition by Lineweaver-burk plot analysis2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674683Inhibition of metallo-beta-lactamase in Klebsiella pneumoniae ATCC 700603 assessed as reduction in cefazolin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
AID674681Inhibition of Imis in Escherichia coli BL21(DE3) assessed as reduction in cefazolin MIC after 24 hrs by macrobroth dilution assay2012Bioorganic & medicinal chemistry letters, Aug-15, Volume: 22, Issue:16
N-heterocyclic dicarboxylic acids: broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's0 (0.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.27 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycolic acid
glycolic acid: RN given refers to parent cpd. glycolic acid : A 2-hydroxy monocarboxylic acid that is acetic acid where the methyl group has been hydroxylated.		1.98102-hydroxy monocarboxylic acid;
primary alcohol		keratolytic drug;
metabolite
glyoxylic acid
glyoxylic acid: RN given refers to parent cpd. glyoxylic acid : A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.		1.98102-oxo monocarboxylic acid;
aldehydic acid		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
n-vinyl-2-pyrrolidinone
N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source		2.0810pyrrolidin-2-ones
4-cyanopyridine
4-cyanopyridine: spectroscopic probe for cytochrome P450 BM3		2.0810
thiazoles
[no description available]		2.67301,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazolidine-4-carboxylic acid
thiazolidine-4-carboxylic acid: active against thimerosal intoxication; acts on cell membranes of tumor cells causing reverse transformation to normal cells; RN given refers to parent cpd		6.9710alpha-amino acid zwitterion;
non-proteinogenic alpha-amino acid;
sulfur-containing amino acid;
thiazolidinemonocarboxylic acid		antidote;
antioxidant;
hepatoprotective agent
dipicolinic acid
dipicolinic acid : A pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6.		2.1710pyridinedicarboxylic acidbacterial metabolite
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		3.150thiazolidine
cefazolin
Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.		2.1710beta-lactam antibiotic allergen;
cephalosporin;
tetrazoles;
thiadiazoles		antibacterial drug
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		1.9810cysteiniumfundamental metabolite
oxalates
Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials