| AID73950 | Inhibitory activity against glycogen synthase kinase-3 (GSK-3beta). | 2003 | Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
| Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching. |
| AID1687062 | Inhibition of Escherichia coli MurA using UNAG and PEP as substrate preincubated for 30 mins in presence of UNAG followed by PEP addition and measured after 15 mins by malachite green colorimetric assay | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID1687069 | Inhibition of recombinant cathepsin X (unknown origin) expressed in Pichia pastoris assessed as residual activity at 100 uM using Abz-Fek(Dnp)-OH as substrate preincubated for 30 mins under shaking in presence of 5 mM cysteine followed by substrate additi | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID605820 | Inhibition of GSK3-beta using GS1 as substrate and [gamma-32P]ATP after 20 mins by radiometric assay | 2011 | Journal of medicinal chemistry, Jun-23, Volume: 54, Issue:12
| Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds. |
| AID227010 | Ratio between dissociation constant and First-order rate constant (Ki / K inact) was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship. |
| AID165176 | Dissociation constant towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrate | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship. |
| AID1687063 | Inhibition of Staphylococcus aureus MurA expressed in Escherichia coli using UNAG and PEP as substrate preincubated for 30 mins in presence of UNAG followed by PEP addition and measured after 15 mins by malachite green colorimetric assay | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID1687066 | Inhibition of Escherichia coli MurA assessed as residual activity at 100 uM using UNAG and PEP as substrate preincubated for 30 mins in presence of UNAG followed by PEP addition and measured after 15 mins in presence of 5 mM cysteine by malachite green co | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID1687068 | Inhibition of recombinant cathepsin B (unknown origin) exopeptidase activity expressed in Escherichia coli assessed as residual activity at 100 uM using Abz-GIVRAK(Dnp)-OH as substrate preincubated for 30 mins under shaking in presence of 5 mM cysteine fo | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID1687067 | Inhibition of recombinant cathepsin B (unknown origin) endopeptidase activity expressed in Escherichia coli assessed as residual activity at 100 uM using Z-RR-AMC as substrate preincubated for 30 mins under shaking in presence of 5 mM cysteine followed by | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID1266909 | Inhibition of glycogen synthase kinase-3 beta (unknown origin) using GS-1 as substrate after 20 mins by scintillation counting analysis in presence of [gamma-32P]-ATP | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease. |
| AID1687064 | Inhibition of Staphylococcus aureus MurA expressed in Escherichia coli assessed as residual activity at 100 uM using UNAG and PEP as substrate preincubated for 30 mins in presence of UNAG followed by PEP addition and measured after 15 mins by malachite gr | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID165175 | First-order rate constant (K inact) for conversion of the ExI complex (Protein-tyrosine phosphatase 1B -inhibitor complex) into the covalent adduct, EI was determined using PNP as substrate | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship. |
| AID1687065 | Inhibition of Escherichia coli MurA assessed as residual activity at 100 uM using UNAG and PEP as substrate preincubated for 30 mins in presence of UNAG followed by PEP addition and measured after 15 mins by malachite green colorimetric assay relative to | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | A road map for prioritizing warheads for cysteine targeting covalent inhibitors. |
| AID1796103 | Kinase Inhibition Assay from Article 10.1021/jm034108b: \\Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3 beta) from a library of compound searching.\\ | 2003 | Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
| Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |