Compounds > 2-bromo-2'-deoxyadenosine
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2-bromo-2'-deoxyadenosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID10065192
CHEMBL ID3143081
SCHEMBL ID5549318
MeSH IDM0143181

Synonyms (10)

Synonym
2-bromo-2'-deoxyadenosine
89178-21-2
adenosine,2-bromo-2'-deoxy- (9ci)
UYDKYWTWCPKLJR-KVQBGUIXSA-N
SCHEMBL5549318
2-bromodeoxyadenosine
CHEMBL3143081
(2r,3s,5r)-5-(6-amino-2-bromo-9h-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol
(2r,3s,5r)-5-(6-amino-2-bromopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
(2r,3s,5r)-5-(6-amino-2-bromo-9h-purin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" At an optimum dosage schedule, 2-BrdAdo and 2-CldAdo have similar therapeutic effects against L1210 in vivo, both producing over 99% cell kill, but the optimum dosage of 2-CldAdo is lower."( Effects of cytotoxicity of 2-chloro-2'-deoxyadenosine and 2-bromo-2'-deoxyadenosine on cell growth, clonogenicity, DNA synthesis, and cell cycle kinetics.
Ashmun, RA; Avery, TL; Blakley, RL; Huang, MC; Kuehl, M, 1986)		0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (99)

Assay IDTitleYearJournalArticle
AID98240Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 17.3 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98257Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 30 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID101900Antitumor activity expressed percentage increase in life span was determined against inoculated M5076 Ovarian Carcinoma in mice by 22.5 mg/kg dosage of compound (qd3hx8), for days 1,4,7,15,18,211984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96960Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97911Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 17.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97094Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96974Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 140 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98255Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID102043Antitumor activity was evaluated by measuring tumor volume in mice1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98060Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 110 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID102040Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 22.5 mg/kg (qd3hx8),days 1,4,7,15,18,211984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96959Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97097Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 70 mg/kg dosage of compound (qd (x 3), for days 1-7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98250Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98407Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98252Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 110 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96963Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96979Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98073Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 90 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID44000Compound was tested for cytotoxicity against CCRF-CEM cell lines1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
AID97099Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 90 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID102038Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 22.5 mg/kg (qd3hx8),days 1,4,7,101984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98058Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98243Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98056Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98074Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 90 mg/kg dosage of compound (qd (x 3), for days 1- 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96971Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97098Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 90 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96961Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 17.3 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96966Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97915Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1,5,9) and long term survivors (mice) was reported; 1/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID101899Antitumor activity expressed percentage increase in life span was determined against inoculated M5076 Ovarian Carcinoma in mice by 22.5 mg/kg dosage of compound (qd3hx8), for days 1,4,7,10,13,161984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98061Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 110 mg/kg dosage of compound (qd (x 3), for days 1- 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98054Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1,5,9) and long term survivors (mice) was reported; 5/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98066Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 30 mg/kg dosage of compound (qd (x 3), for days 1- 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97914Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97916Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 7/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98071Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 70 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98412Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 90 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID101903Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 11.3 mg/kg (qd3hx8),days 1-341984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98246Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96978Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 30 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98070Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 50 mg/kg dosage of compound (qd (x 3), for days 1- 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96970Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97096Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 70 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96964Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98065Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98410Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 70 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98067Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98256Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98409Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 70 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96969Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98242Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97093Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98238Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98258Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98057Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1,5,9) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98247Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID101902Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 11.3 mg/kg (qd3hx8),days 1,4,7,101984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98259Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98245Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98248Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1,5,9)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96977Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96972Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 110 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98239Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96710Compound was tested for cytotoxicity against L1210 cell lines1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
AID98055Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98068Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98249Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97910Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16) and long term survivors (mice) was reported; 1/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96976Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98253Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 140 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98064Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98072Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 70 mg/kg dosage of compound (qd (x 3), for days 1- 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID81745Compound was tested for cytotoxicity against HEp-2 cell lines1992Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2
Synthesis and biologic activity of 2'-fluoro-2-halo derivatives of 9-beta-D-arabinofuranosyladenine.
AID98069Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96968Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96975Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 180 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98244Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96967Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 5.6 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98408Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 50 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98254Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 180 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96965Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 45 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98062Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 140 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98251Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 110 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96962Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97913Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 2/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID102041Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 22.5 mg/kg (qd3hx8),days 1-341984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID102039Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 22.5 mg/kg (qd3hx8),days 1,4,7,10,13,161984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98411Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 90 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID96973Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 110 mg/kg dosage of compound (qd (x 3), for days 1-7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98059Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 11.3 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7,10,13,16) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97912Antitumor activity determined against inoculated L1210 leukemia cells (1*10e5) in mice by 17.3 mg/kg dosage of compound (qd (x 3), for days 1,5,9) and long term survivors (mice) was reported; 0/121984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID101901Antitumor activity expressed percentage increase in life span was determined against inoculated M5076 Ovarian Carcinoma in mice by 11.3 mg/kg dosage of compound (qd3hx8), for days 1,4,7,101984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98241Antitumor activity expressed as life span was determined against inoculated L1210 leukemia cells (1*10e5) in mice by 22.5 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID97095Antitumor activity expressed percentage increase in life span was determined against inoculated L1210 leukemia cells (1*10e6) in mice by 50 mg/kg dosage of compound (qd (x 3), for days 1- 7)1984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID102042Antitumor activity was evaluated by measuring mean life span in tumor (M5076) inoculated mice at 5.6 mg/kg (qd3hx8),days 1-341984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID98063Antitumor activity determined against inoculated L1210 leukemia cells (1*10e6) in mice by 180 mg/kg dosage of compound (qd (x 3), for days 1, 4, 7) and long term survivors (mice) was reported; 0/61984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
AID101898Antitumor activity expressed percentage increase in life span was determined against inoculated M5076 Ovarian Carcinoma in mice by 22.5 mg/kg dosage of compound (qd3hx8), for days 1,4,7,101984Journal of medicinal chemistry, Jun, Volume: 27, Issue:6
Improved synthesis and antitumor activity of 2-bromo-2'-deoxyadenosine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cytarabine
[no description available]		1.9710beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside		antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent
2-chloroadenosine
5-chloroformycin A: structure given in first source		1.9810purine nucleoside
cladribine
[no description available]		3.0850organochlorine compound;
purine 2'-deoxyribonucleoside		antineoplastic agent;
immunosuppressive agent
clofarabine
[no description available]		1.9810adenosines;
organofluorine compound		antimetabolite;
antineoplastic agent
demecolcine
Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.. (-)-demecolcine : A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than colchicine and is used as an antineoplastic.		1.9710alkaloid;
secondary amino compound		antineoplastic agent;
microtubule-destabilising agent
2'-deoxy-2-fluoroadenosine
2'-deoxy-2-fluoroadenosine: structure in first source		1.9810adenosines;
organofluorine compound
fludarabine
[no description available]		1.9810purine nucleoside
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9810
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		01.9810
Leukemia L 1210
[description not available]		02.8840
Malignant Melanoma
[description not available]		01.9610
Cancer of Ovary
[description not available]		01.9610
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		01.9610
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		01.9610
Leucocythaemia
[description not available]		0210
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		0210
Benign Neoplasms, Brain
[description not available]		01.9710
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		01.9710
Acute Myelogenous Leukemia
[description not available]		01.9710
Leukemia, Myeloid, Acute
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.		01.9710