Page last updated: 2024-10-15

2-azahypoxanthine

Description

2-azahypoxanthine: metabolite of DTIC; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135421876
SCHEMBL ID2473003
MeSH IDM0060021

Synonyms (47)

Synonym
4h-imidazo(4,5-d)-v-triazin-4-one, 3,7-dihydro-
tgz8a8pwex ,
einecs 225-096-3
unii-tgz8a8pwex
1,5-dihydro-4h-imidazo(4,5-d)-1,2,3-triazin-4-one
4h-imidazo(4,5-d)-1,2,3-triazin-4-one, 1,5-dihydro-
4h-imidazo[4, 3,7-dihydro-
4656-86-4
nsc-22419
nsc22419
2-azahypoxanthine
4h-imidazo[4,2,3-triazin-4-one, 1,5-dihydro-
nsc 22419
AKOS006349707
FT-0662365
3,7-dihydro-imidazo[4,5-e][1,2,3]triazin-4-one
3h,4h,7h-imidazo[4,5-d][1,2,3]triazin-4-one
GS-0021
dacarbazine impurity a [ep impurity]
temozolomide impurity e [ep impurity]
temozolomide impurity, 2-azahypoxanthine- [usp impurity]
4h-imidazo(4,5-d)-1,2,3-triazin-4-one, 3,7-dihydro-
3,7-dihydro-4h-imidazo(4,5-d)-1,2,3-triazin-4-one
4a,5-dihydro-4h-imidazo(4,5-d)(1,2,3)triazin-4-one
1,5-dihydro-4h-imidazo[4,5-d]-1,2,3-triazin-4-one
SCHEMBL2473003
AC-30425
dacarbazine ep impurity a
AKOS028108945
3,7-dihydro-4h-imidazo[4,5-d]-1,2,3-triazin-4-one
mfcd19216826
4h-imidazo[4,5-d]-1,2,3-triazin-4-one, 1,5-dihydro-
3h-imidazo[4,5-d][1,2,3]triazin-4(7h)-one
dacarbazine impurity a
3,7-dihydroimidazo[4,5-d][1,2,3]triazin-4-one
imidazo-[4,5-d]-v-triazin-4(3h)-one
3,7-dihydro-4h-imidazo[4,5-d][1,2,3]triazin-4-one
CS-0037139
2-azahypoxanthine; 3,7-dihydro-4h-imidazo[4,5-d]-1,2,3-triazin-4-one
3,5-dihydroimidazo[4,5-d]triazin-4-one
DTXSID00963606
7h-imidazo[4,5-d][1,2,3]triazin-4-ol
Q27289957
EN300-208225
3,7-dihydro-4h-imidazo[4,5-d]-1,2,3-triazin-4-one sodium salt
SY124591
Z1203731027

Toxicity

ExcerptReference
"Decomposition of the antitumor agent 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC, Dacarbazine) produces several potentially toxic compounds, the concentration of which depend on incubation parameters such as pH, temperature and illumination."( Mechanisms of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (Dacarbazine) cytotoxicity toward Chinese hamster ovary cells in vitro are dictated by incubation conditions.
Chao, LY; DeChang, W; Saunders, PP, 1986
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (31.25)18.7374
1990's1 (6.25)18.2507
2000's0 (0.00)29.6817
2010's7 (43.75)24.3611
2020's3 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]