Compounds > 2-amino-5-bromo-6-(3-fluorophenyl)-4(3h)pyrimidinone

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2-amino-5-bromo-6-(3-fluorophenyl)-4(3h)pyrimidinone

Description

2-amino-5-bromo-6-(3-fluorophenyl)-4(3H)pyrimidinone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	135407143
CHEMBL ID	296806
SCHEMBL ID	7776236
SCHEMBL ID	8995826
MeSH ID	M0123770

Synonyms (14)

Synonym
2-amino-5-bromo-6-(3-fluorophenyl)-4(3h)-pyrimidinone
2-amino-5-bromo-4-(3-fluorophenyl)-1h-pyrimidin-6-one
abmfpp
CHEMBL296806
74602-59-8
4(1h)-pyrimidinone, 2-amino-5-bromo-6-(3-fluorophenyl)-
2-amino-5-bromo-6-(3-fluorophenyl)-4(3h)pyrimidinone
DTXSID10225580
SCHEMBL7776236
SCHEMBL8995826
2-amino-5-bromo-6-(3-fluorophenyl)-4(3h)-pyrimidinone #
LOQWIXAMWLMCQY-UHFFFAOYSA-N
pyrimidin-4(3h)-one, 2-amino-5-bromo-6-(3-fluorophenyl)-
2-amino-5-bromo-6-(3-fluorophenyl)pyrimidin-4(3h)-one

Dosage Studied

Excerpt	Reference
" The best therapeutic response was observed when pyrimidinone was given every 4 days for a total of 7 injections; however, other schedules and dosing frequencies also gave significant responses."	( Chemoimmunotherapy of B 16 melanoma and P388 leukemia with cyclophosphamide and pyrimidinones. Johnson, MA; Li, LH; Moeller, RB; Wallace, TL, 1984)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID119051	Protection index after intraperitoneal administration (25 mg/kg/day) against herpes simplex virus type-1 (HSV-1) infected mice [protection index=(control mortality-treated mortality)/control mortality]	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents.
AID113840	Effective dose administered subcutaneously againist Forest virus infected mice	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents.
AID113834	Antiviral activity against Forest virus (SFV)	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents.
AID112587	Evaluation for serum interferon response from a single 800 mg/kg intraperitoneal administration in vesicular stomatitis virus on L292 cells.	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents.
AID113838	Effective dose administered perorally againist Forest virus infected mice	1985	Journal of medicinal chemistry, Dec, Volume: 28, Issue:12	Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
cytosine [no description available]	2.88	4	0	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
asialo gm1 ganglioside [no description available]	1.96	1	0
g(m1) ganglioside G(M1) Ganglioside: A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.. ganglioside GM1 : A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stearoylsphingosine via a beta-linkage.	1.96	1	0	alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine; sialotetraosylceramide
2-amino-5-iodo-6-phenyl-4-pyrimidinone [no description available]	1.96	1	0
bropirimine [no description available]	2.66	3	0	pyrimidines
pyrimidinones Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.	1.97	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Herpes Simplex Virus Infection [description not available]	0	1.96	1	0
Viral Diseases [description not available]	0	1.96	1	0
Infections, Togaviridae [description not available]	0	1.96	1	0
Herpes Simplex A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	0	1.96	1	0
Virus Diseases A general term for diseases caused by viruses.	0	1.96	1	0
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	0	2.66	3	0
Experimental Leukemia [description not available]	0	2.66	3	0
Malignant Melanoma [description not available]	0	2.37	2	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	0	2.37	2	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	0	1.96	1	0
Polyarthritis [description not available]	0	1.96	1	0
Adjuvant Arthritis [description not available]	0	1.96	1	0
Arthritis Acute or chronic inflammation of JOINTS.	0	1.96	1	0
Hepatitis, Viral, Animal INFLAMMATION of the LIVER in animals due to viral infection.	0	1.97	1	0
Leukemia L 1210 [description not available]	0	1.96	1	0