Page last updated: 2024-12-07
2,6-dimethylacetaminophen
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
2,6-dimethylacetaminophen: structure given in first source; major urinary metabolite of lidocaine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 80641 |
CHEMBL ID | 15679 |
SCHEMBL ID | 20857699 |
MeSH ID | M0131939 |
Synonyms (31)
Synonym |
---|
2,6-dimethyl-4-hydroxyacetanilide |
2',6'-acetoxylidide, 4'-hydroxy- |
acetamide, n-(2,6-dimethyl-4-hydroxyphenyl)- |
nsc 38035 |
brn 2804933 |
acetamide, n-(4-hydroxy-2,6-dimethylphenyl)- |
2,6-dimethylacetaminophen |
nsc38035 |
nsc-38035 |
6337-56-0 |
4-hydroxy-2,6-dimethylacetanilide |
CHEMBL15679 |
2,6-dimethylparacetamol |
FT-0669549 |
n-(4-hydroxy-2,6-dimethylphenyl)acetamide |
AKOS001044941 |
1-13-00-00245 (beilstein handbook reference) |
unii-r7r7ko00sw |
r7r7ko00sw , |
4-acetamido-3,5-dimethylphenol |
mfcd00748645 |
SY016115 |
DTXSID70212774 |
n-(4-hydroxy-2,6-dimethylphenyl)acet-amide |
SCHEMBL20857699 |
AC6513 |
3,5-dimethyl-4-acetaminophenol |
A868161 |
LS-07623 |
4?-hydroxy-2?,6?-acetoxylidide |
Z56871774 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (40)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID120611 | Nephrotoxicity upon intragastric administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120610 | Nephrotoxicity upon intragastric administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191472 | Nephrotoxicity upon intragastric administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191471 | Nephrotoxicity upon intragastric administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191482 | Nephrotoxicity upon intraperitoneal administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120608 | Nephrotoxicity upon intragastric administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191487 | Nephrotoxicity upon intravenous administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191491 | Nephrotoxicity upon intravenous administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID123230 | Nephrotoxicity upon intraperitoneal administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120613 | Nephrotoxicity upon intragastric administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191489 | Nephrotoxicity upon intravenous administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120609 | Nephrotoxicity upon intragastric administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120619 | Nephrotoxicity upon intraperitoneal administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID123231 | Nephrotoxicity upon intraperitoneal administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120607 | Nephrotoxicity upon intragastric administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191473 | Nephrotoxicity upon intragastric administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191485 | Nephrotoxicity upon intraperitoneal administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191492 | Nephrotoxicity upon intravenous administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191480 | Nephrotoxicity upon intraperitoneal administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191474 | Nephrotoxicity upon intragastric administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120612 | Nephrotoxicity upon intragastric administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120618 | Nephrotoxicity upon intraperitoneal administration was assessed in mice liver as centrilobular vacuolation or necrosis at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191470 | Nephrotoxicity upon intragastric administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120614 | Nephrotoxicity upon intraperitoneal administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191477 | Nephrotoxicity upon intragastric administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191484 | Nephrotoxicity upon intraperitoneal administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191476 | Nephrotoxicity upon intragastric administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120616 | Nephrotoxicity upon intraperitoneal administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191478 | Nephrotoxicity upon intraperitoneal administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191481 | Nephrotoxicity upon intraperitoneal administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191483 | Nephrotoxicity upon intraperitoneal administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191479 | Nephrotoxicity upon intraperitoneal administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191475 | Nephrotoxicity upon intragastric administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191488 | Nephrotoxicity upon intravenous administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 2 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191493 | Nephrotoxicity upon intravenous administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191490 | Nephrotoxicity upon intravenous administration was assessed in rat liver as centrilobular vacuolation or necrosis at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120606 | Nephrotoxicity upon intragastric administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120617 | Nephrotoxicity upon intraperitoneal administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 5 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID191486 | Nephrotoxicity upon intravenous administration was assessed in rat kidney as proximal tublar necrosis deep in the cortex at a dose of 1 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
AID120615 | Nephrotoxicity upon intraperitoneal administration was assessed in mice kidney as proximal tublar necrosis deep in the cortex at a dose of 10 mM | 1980 | Journal of medicinal chemistry, Nov, Volume: 23, Issue:11 | Studies on the mechanism of toxicity of acetaminophen. Synthesis and reactions of N-acetyl-2,6-dimethyl- and N-acetyl-3,5-dimethyl-p-benzoquinone imines. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 6 (60.00) | 18.7374 |
1990's | 3 (30.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (10.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.82
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.82) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 10 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |