Page last updated: 2024-12-06
2,6-dihydroxypyridine
Description
2,6-Dihydroxypyridine is a heterocyclic compound with two hydroxyl groups attached to the pyridine ring at positions 2 and 6. It is a white crystalline solid with a melting point of 168-170 °C. It is a weak acid, readily soluble in water and ethanol, and has been studied extensively for its potential pharmacological activities. 2,6-Dihydroxypyridine has been shown to exhibit antioxidant activity, inhibiting lipid peroxidation and scavenging free radicals. It has also been reported to possess anti-inflammatory properties, reducing inflammation in animal models. Its mechanism of action is believed to be through the inhibition of enzymes such as cyclooxygenase (COX) and lipoxygenase (LOX), which are involved in the production of inflammatory mediators. In addition to its potential as a therapeutic agent, 2,6-dihydroxypyridine is also used as a starting material in the synthesis of other biologically active compounds. Its ease of synthesis and versatility make it a valuable building block in medicinal chemistry.'
2,6-dihydroxypyridine: inhibits dihydropyrimidine dehydrogenase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 69371 |
| CHEMBL ID | 3086507 |
| CHEBI ID | 17681 |
| SCHEMBL ID | 128525 |
| MeSH ID | M0236445 |
Synonyms (37)
| Synonym |
|---|
| AC-3350 |
| 6-hydroxy-2(1h)-pyridinone |
| einecs 210-927-4 |
| STL290514 |
| CHEBI:17681 , |
| 2(1h)-pyridone, 6-hydroxy- |
| 2(1h)-pyridinone, 6-hydroxy- |
| 626-06-2 |
| 2,6-dihydroxypyridine |
| C03056 |
| pyridine-2,6-diol |
| 6-hydroxy-1h-pyridin-2-one |
| 2,6-pyridinediol |
| A833878 |
| AKOS006230481 |
| unii-54009b6txp |
| 54009b6txp , |
| FT-0601051 |
| CHEMBL3086507 |
| dihydroxypyridine, 2,6- |
| 14346-45-3 |
| 1-deazauracil |
| 6-hydroxy-2-pyridone |
| 2-hydroxy-6-pyridinone |
| SCHEMBL128525 |
| mfcd00129028 |
| SY004410 |
| 6-hydroxy-2(1h)-pyridinone # |
| DTXSID90211643 |
| 6-oxidanyl-1h-pyridin-2-one |
| J-507488 |
| Q4596805 |
| AS-31062 |
| 2_6-dihydroxypyridine |
| SB52511 |
| CS-0186522 |
| PD099111 |
Drug Classes (1)
| Class | Description |
|---|
| dihydroxypyridine | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 21.93
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 21.93 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.42 (4.65) | | Search Engine Demand Index | 18.60 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |