Compounds > 2,4-dinitroimidazole-1-ethanol
Page last updated: 2024-12-07

2,4-dinitroimidazole-1-ethanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,4-dinitroimidazole-1-ethanol: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID125775
CHEMBL ID350013
SCHEMBL ID3303223
MeSH IDM0073637

Synonyms (10)

Synonym
ka 161
2-(2,4-dinitroimidazol-1-yl)ethanol
CHEMBL350013
69542-89-8
1h-imidazole-1-ethanol, 2,4-dinitro-
2,4-dinitroimidazole-1-ethanol
ka-161
SCHEMBL3303223
DTXSID00989523
2-(2,4-dinitro-1h-imidazol-1-yl)ethan-1-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID229115Radiosensitizing effectivity evaluated as its ability to sensitize hypoxic Chinese hamster cells (V-79) towards ionizing radiation at 0.1 mM1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Potential radiosensitizing agents. 2. Synthesis and biological activity of derivatives of dinitroimidazole with oxiranes.
AID1123542Induction of sensitization to irradiation in Escherichia coli AB1157 under hypoxic condition assessed as reduction in colony formation at 1 mM measured after irradiation1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Potential radiosensitizing agents. Dinitroimidazoles.
AID1123544Induction of sensitization to irradiation in Escherichia coli AB1157 under oxic condition assessed as reduction in colony formation at 1 mM measured after irradiation1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Potential radiosensitizing agents. Dinitroimidazoles.
AID1123543Antimicrobial activity against Escherichia coli AB1157 assessed as reduction in colony formation at 1 mM1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Potential radiosensitizing agents. Dinitroimidazoles.
AID84701Concentration needed to achieve 50% kill of chinese hamster cells under oxygenated conditions on exposure for 2 hours1981Journal of medicinal chemistry, May, Volume: 24, Issue:5
Potential radiosensitizing agents. 2. Synthesis and biological activity of derivatives of dinitroimidazole with oxiranes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.25 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
azomycin
azomycin: RN given refers to parent cpd with specified locant; structure		3.2260C-nitro compound;
imidazoles		antitubercular agent
misonidazole
Misonidazole: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.		8.0650
pimonidazole
pimonidazole: structure given in first source		1.9610
1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole
1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole: structure given in first source		1.9710
oxadiazoles
Oxadiazoles: Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms.		1.9610
mo 113
MO 113: structure given in first source		1.9610
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Mammary Neoplasms
[description not available]		02.6630
Experimental Neoplasms
[description not available]		01.9610
Anoxemia
[description not available]		01.9610
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		01.9610