Compounds > 2,4,6-tris(dimethylaminomethyl)phenol
Page last updated: 2024-12-05

2,4,6-tris(dimethylaminomethyl)phenol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,4,6-tris(dimethylaminomethyl)phenol is a versatile organic compound with a complex structure. It is a derivative of phenol, modified with three dimethylaminomethyl groups. The compound is known for its potential application in coordination chemistry as a chelating agent, owing to the presence of multiple nitrogen and oxygen donor atoms. It has also been investigated for its potential in materials science, particularly for the synthesis of polymers and metal-organic frameworks. Its synthesis typically involves the reaction of phenol with formaldehyde and dimethylamine, leading to the introduction of the dimethylaminomethyl groups. Research interest in this compound stems from its unique structural features and its ability to form stable complexes with various metals. However, further investigation is needed to fully understand its properties and applications. '
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2,4,6-tris(dimethylaminomethyl)phenol: a promoter factor for spreading circular DNA, linear DNA, and DNA-protein complexes [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7026
CHEMBL ID1887090
SCHEMBL ID36297
MeSH IDM0212229

Synonyms (103)

Synonym
EU-0033631
AC-15151
LS-14450
EN300-19383
c15h27n3o
dmp 30
tris-2,6-dimethylaminomethylphenol
90-72-2
s 41028-4
wln: 1n1&1r bq c1n1&1 e1n1&1
dmf 3
tris(2,6-dimethylaminomonomethyl)phenol
mesitol,.alpha.',.alpha.''-tris(dimethylamino)-
nsc3257
mesitol,.alpha.4,.alpha.6-tris(dimethylamino)-
phenol,4,6-tris[(dimethylamino)methyl]-
nsc-3257
2,6-tris[(n,n-dimethylamino)methyl]phenol
2,6-tris-[(dimethylamino)methyl]phenol
2,6-tris[(dimethylamino)methyl]phenol
.alpha.,.alpha.''-tris(dimethylamino)mesitol
dmp-30
2,6-tris-n,n-dimethylaminomethylfenol
.alpha.,.alpha.''-tri(dimethylamino)mesitol
tris(2,6-dimethylaminomethyl)phenol
2,6-tri(dimethylaminomethyl)phenol
mesitol, .alpha.,.alpha.',.alpha.''-tris(dimethylamino)-
phenol, 2,4,6-tris[(dimethylamino)methyl]-
2,4,6-tris[(dimethylamino)methyl]phenol
mesitol, alpha2,alpha4,alpha6-tris(dimethylamino)-
anchor k 54
einecs 202-013-9
eh 30
epilink 230
capcure eh 30
actiron nx 3
araldite hardener hy 960
dabco tmr 30
araldite dy 061
2,4,6-tri(dimethylaminomethyl)phenol
up 606/2
2,4,6-tris-n,n-dimethylaminomethylfenol [czech]
ai3-03346
ancamine k 54
mesitol, alpha(sup 2),alpha(sup 4),alpha(sup 6)-tris(dimethylamino)-
2,4,6-tris(dimethylaminomethyl)phenol
araldite hy 960
alpha,alpha',alpha''-tris(dimethylamino)mesitol
brn 0795751
phenol, 2,4,6-tris((dimethylamino)methyl)-
nsc 3257
sumicure d
dy 061
araldite dy 064
2,4,6-tris((n,n-dimethylamino)methyl)phenol
OPREA1_762610
CHEMDIV2_000266
inchi=1/c15h27n3o/c1-16(2)9-12-7-13(10-17(3)4)15(19)14(8-12)11-18(5)6/h7-8,19h,9-11h2,1-6h
2,4,6-tris(dimethylaminomethyl)phenol, 95%
NCGC00164152-01
epoxy embedding medium, accelerator, >=95% (nt)
HMS1369M02
T0526
AKOS001588352
NCGC00164152-02
tris(dimethylaminomethyl)phenol
tox21_303329
cas-90-72-2
dtxcid006548
NCGC00257020-01
dtxsid5026548 ,
NCGC00259444-01
tox21_201895
mesitol, alpha,alpha',alpha''-tris(dimethylamino)-
ec 202-013-9
hsdb 8201
2,4,6-tris-n,n-dimethylaminomethylfenol
unii-2agn35qf4w
2agn35qf4w ,
4-13-00-01946 (beilstein handbook reference)
FT-0609924
SCHEMBL36297
tris(dimethylaminomethyl)phenol, 2,4,6-
2,4,6-tris((dimethylamino)methyl)phenol
ancamine k54
2,4,6-tris[(n,n-dimethylamino)methyl]phenol
2,4,6-tris[(dimethyllamino)methyl]-phenol
.alpha.,.alpha.',.alpha.''-tris(dimethylamino)mesitol
.alpha.,.alpha.',.alpha.''-tri(dimethylamino)mesitol
tris(2,4,6-dimethylaminomethyl)phenol
mesitol, .alpha.2,.alpha.4,.alpha.6-tris(dimethylamino)-
tris(2,4,6-dimethylaminomonomethyl)phenol
W-100326
CHEMBL1887090
sr-01000390646
SR-01000390646-1
mfcd00008330
BCP22023
2,4,6-tris-dimethylaminomethyl-phenol
Q27254480
2,4,6-tris(dimethyl aminomethyl)phenol
CS-W010125
E82984
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (7)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency43.23310.000714.592883.7951AID1259369
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.15850.000214.376460.0339AID588532
estrogen nuclear receptor alphaHomo sapiens (human)Potency19.49620.000229.305416,493.5996AID743075
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency1.25890.010039.53711,122.0200AID588547
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency61.13060.000323.4451159.6830AID743065
heat shock protein beta-1Homo sapiens (human)Potency54.94770.042027.378961.6448AID743210
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency41.37920.000627.21521,122.0200AID743202; AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.11 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index49.81 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies4 (40.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.0710halide anion;
monoatomic bromine
phenol
[no description available]		7.610phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
1-propanol
1-Propanol: A colorless liquid made by oxidation of aliphatic hydrocarbons that is used as a solvent and chemical intermediate.. propan-1-ol : The parent member of the class of propan-1-ols that is propane in which a hydrogen of one of the methyl groups is replaced by a hydroxy group.		1.9810propan-1-ols;
short-chain primary fatty alcohol		metabolite;
protic solvent
cetylpyridinium
Cetylpyridinium: Cationic bactericidal surfactant used as a topical antiseptic for skin, wounds, mucous membranes, instruments, etc.; and also as a component in mouthwash and lozenges.		1.9810pyridinium ion
haloperidol
Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.		2.9940aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.		2.0710nitrosaminegeroprotector;
mutagen
diethylenetriamine
diethylenetriamine: RN given refers to parent cpd		2.110polyazaalkane;
triamine
1,3-xylenediamine
1,3-xylenediamine: structure given in first source		2.110
isophorone diamine
isophorone diamine: curing agent for polymers; structure given in first source; RN given refers to parent cpd		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Allergic Contact Dermatitis
[description not available]		08.4970
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		03.4970
Dermatitis, Occupational
A recurrent contact dermatitis caused by substances found in the work place.		02.9440
Contact Dermatitis
[description not available]		02.1310
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		02.1310