2,4,6-tribromoanisole profile

2,4,6-Tribromoanisole is a brominated derivative of anisole. It has been synthesized via various methods, including the bromination of anisole using bromine in the presence of a Lewis acid catalyst, such as iron(III) bromide. This compound has been investigated for its potential biological activities, including its effects on the central nervous system and its antimicrobial properties. It is also used as an intermediate in the synthesis of other organic compounds. Research on 2,4,6-tribromoanisole is ongoing to explore its potential applications in different fields, such as pharmaceuticals, agrochemicals, and materials science.'
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2,4,6-tribromoanisole: produced by O-methylation of its direct precursor, 2,4,6-tribromophenol, generally comes from sources in the winery environment [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	11839
SCHEMBL ID	301662
MeSH ID	M0465116

Synonym
do7m3m4lx5 ,
unii-do7m3m4lx5
methyl 2,4,6-tribromophenyl ether
hsdb 7814
ai3-00641
2,4,6-tba
nsc 2218
nsc-2218
nsc2218
607-99-8
benzene,3,5-tribromo-2-methoxy-
methyl 2,6-tribromophenyl ether
anisole,4,6-tribromo-
2,6-tribromoanisole
benzene, 1,3,5-tribromo-2-methoxy-
anisole, 2,4,6-tribromo-
2,4,6-tribromoanisole
2,4,6-tribromoanisole, 99%
T2301
AKOS000277640
1,3,5-tribromo-2-methoxybenzene
yxtrcoafnxqtkl-uhfffaoysa-
inchi=1/c7h5br3o/c1-11-7-5(9)2-4(8)3-6(7)10/h2-3h,1h3
A832891
1,3,5-tribromo-2-methoxy-benzene
FT-0632532
SCHEMBL301662
2,4,6-tribromoanisole [hsdb]
2,4,6-tribromoanisole [mi]
J-503844
DTXSID1060558
1219795-33-1
1,3,5-tribromo-2-methoxybenzene #
YXTRCOAFNXQTKL-UHFFFAOYSA-N
mfcd00192510
2,4,6-tribromoanisole, pestanal(r), analytical standard
2,4,6-tribromoanisole 10 microg/ml in isooctane
BBL102160
STL555959
Q4596770
PS-10191
D92594
2,4,6-tribromoanisole 1000 microg/ml in methanol
CS-0136295

Excerpt	Reference	Relevance
" The bioavailability of the liposomes was evaluated in rabbits, compared with the conventional self-emulsifying formulation for oral administration."	( Preparation of liposomes containing zedoary turmeric oil using freeze-drying of liposomes via TBA/water cosolvent systems and evaluation of the bioavailability of the oil. Fu, D; Yang, Z; Yu, S, 2010)	0.36

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (56.52)	29.6817
2010's	10 (43.48)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
choline [no description available]	2.05	1	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
2,4,6-tribromophenol [no description available]	2.45	2	bromophenol	environmental contaminant; fungicide; marine metabolite
p-aminohippuric acid p-Aminohippuric Acid: The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity.. p-aminohippurate : A hippurate that is the conjugate base of p-aminohippuric acid, arising from deprotonation of the carboxy group.. p-aminohippuric acid : An N-acylglycine that is the 4-amino derivative of hippuric acid; used as a diagnostic agent in the measurement of renal plasma flow.	2.05	1	N-acylglycine	Daphnia magna metabolite
clonidine Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.	2.05	1	clonidine; imidazoline
desipramine Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.. desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.	2.05	1	dibenzoazepine; secondary amino compound	adrenergic uptake inhibitor; alpha-adrenergic antagonist; antidepressant; cholinergic antagonist; drug allergen; EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; H1-receptor antagonist; serotonin uptake inhibitor
diphenhydramine Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.. diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.. antitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.	2.05	1	ether; tertiary amino compound	anti-allergic agent; antidyskinesia agent; antiemetic; antiparkinson drug; antipruritic drug; antitussive; H1-receptor antagonist; local anaesthetic; muscarinic antagonist; oneirogen; sedative
tetraethylammonium Tetraethylammonium: A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)	2.05	1	quaternary ammonium ion
2,3,4,6-tetrachlorophenol 2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.	2.47	2	tetrachlorophenol	xenobiotic metabolite
skatole [no description available]	2.13	1	methylindole	human metabolite; mammalian metabolite
2,4,6-trichloroanisole 2,4,6-trichloroanisole: Cork taint compound. 2,4,6-trichloroanisole : A monomethoxybenzene that is 1,3,5-trichlorobenzene in which one of the hydrogens is replaced by a methoxy group.	3.65	9	monomethoxybenzene; trichlorobenzene
2,4,6-trichlorophenol [no description available]	2.47	2	trichlorophenol	carcinogenic agent
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	2.05	1	xanthene
anisole anisole : A monomethoxybenzene that is benzene substituted by a methoxy group.	2.1	1	monomethoxybenzene	plant metabolite
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.46	2	pyrrole; secondary amine
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2.15	1	diazine; pyrazines	Daphnia magna metabolite
phenacylamine phenacylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #6990	2.13	1	aromatic ketone
tetramethylpyrazine tetramethylpyrazine: found in Ligusticum chuanxiong. tetramethylpyrazine : A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).	2.15	1	alkaloid; pyrazines	antineoplastic agent; apoptosis inhibitor; bacterial metabolite; neuroprotective agent; platelet aggregation inhibitor; vasodilator agent
pentachloroanisole [no description available]	2.1	1
4,5-dimethyl-3-hydroxy-2(5h)-furanone [no description available]	2.13	1	butenolide	metabolite
betulinic acid [no description available]	2.15	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite
lissamine rhodamine b lissamine rhodamine B: RN given refers to parent cpd; Lissamine Rhodamine B refers to Na salt	2.02	1
quinidine Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.	2.05	1	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker
2-acetyl-1-pyrroline 2-acetyl-1-pyrroline: volatile component of uncooked Khao Dawk Mali 105 brown rice were extracted using indirect steam distillation under reduced pressure and controlled temperature in order to prevent cooking. 2-acetyl-1-pyrroline : A pyrroline that is 1-pyrroline in which the hydrogen at position 2 is replaced by an acetyl group. It is an aroma and flavour compound present in jasmine rice and basmati rice. It is responsible for the 'popcorn' aroma in a large variety of cereal and food products. It is one of the key odourants of the crust of bread and considered to be responsible for the cracker-like odour properties. In bread, it is primarily generated during baking but amounts are influenced by ingredient composition and fermentation conditions.	2.13	1	acylimine; methyl ketone; pyrroline	flavouring agent; Maillard reaction product; metabolite
quinine [no description available]	2.05	1	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic
4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole 4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole: a brominated compound, detected in the blubber of dolphins and other marine mammals from Queensland (northeast Australia)	2.02	1

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.96	4	0

2,4,6-tribromoanisole

Description

Cross-References

Synonyms (44)

Research Excerpts

Bioavailability

Research

Studies (23)

Market Indicators

Research Demand Index: 24.54

Study Types