Page last updated: 2024-12-06

2,4,6,2',4',6'-hexachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,4,6,2',4',6'-hexachlorobiphenyl (PCB 153) is a highly chlorinated polychlorinated biphenyl (PCB) congener. It is a persistent organic pollutant (POP) and is known for its resistance to environmental degradation. PCBs were widely used in industrial applications due to their fire-retardant and insulating properties, but their production and use were phased out due to their toxicity and environmental persistence. PCB 153, like other PCBs, is a known endocrine disruptor, meaning it can interfere with the hormone systems of living organisms. It has been linked to reproductive problems, developmental defects, and immune system suppression. PCB 153 is bioaccumulative, meaning it can build up in the food chain, reaching high concentrations in top predators. Due to its widespread environmental contamination and potential health risks, PCB 153 is extensively studied to understand its fate and transport in the environment, its effects on wildlife and human health, and to develop strategies for remediation and risk management.'

2,2',4,4',6,6'-hexachlorobiphenyl : A hexachlorobiphenyl that is biphenyl in which both of the phenyl rings are substituted at positons 2, 4, and 6 by chlorines. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID36647
CHEBI ID34203
SCHEMBL ID2937097
MeSH IDM0088893

Synonyms (30)

Synonym
CHEBI:34203 ,
2,2',4,4',6,6'-hexachloro-1,1'-biphenyl
2,4,6,2',4',6'-hexachlorobiphenyl
2,2',4,4',6,6'-hcb
2,2',4,4',6,6'-hexachlorodiphenyl
biphenyl, 2,2',4,4',6,6'-hexachloro-
brn 2058693
einecs 251-773-8
pcb 155
33979-03-2
inchi=1/c12h4cl6/c13-5-1-7(15)11(8(16)2-5)12-9(17)3-6(14)4-10(12)18/h1-4
2,2',4,4',6,6'-hexachlorobiphenyl
1,1'-biphenyl, 2,2',4,4',6,6'-hexachloro-
1,3,5-trichloro-2-(2,4,6-trichlorophenyl)benzene
unii-r9yk3084vs
r9yk3084vs ,
hexachlorobiphenyl, 2,4,6,2',4',6'-
SCHEMBL2937097
ICOAEPDGFWLUTI-UHFFFAOYSA-N
DTXSID3040302 ,
pcb no. 155
pcb no. 155 10 microg/ml in isooctane
Q27115900
5-(3-(tert-butyl)-1-(cyclopropylmethyl)ureido)-n,n-diethyl-1,3,4-thiadiazole-2-sulfonamide
CS-0451372
SY250283
mfcd00152541
2,2 inverted exclamation mark ,4,4 inverted exclamation mark ,6,6 inverted exclamation mark -hexachlorobiphenyl
246-hcb
dtxcid1020302
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
hexachlorobiphenylAny polychlorobiphenyl with molecular formula C12H4Cl6.
trichlorobenzeneAny member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (16.67)18.7374
1990's2 (16.67)18.2507
2000's4 (33.33)29.6817
2010's3 (25.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.10

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.10 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.10)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]