2,3-dimethylquinoxaline : A quinoxaline derivative in which the quinoxaline (1,4-naphthyridine) skeleton is substituted with a methyl group at each of positions C-2 and C-3. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 16925 |
| CHEMBL ID | 67865 |
| CHEBI ID | 132810 |
| SCHEMBL ID | 103601 |
| Synonym |
|---|
| brn 0114832 |
| einecs 219-162-0 |
| nsc 1789 |
| quinoxaline,3-dimethyl- |
| nsc1789 |
| nsc-1789 |
| wln: t66 bn enj c1 d1 |
| 2,3-dimethylquinoxaline |
| 2379-55-7 |
| quinoxaline, 2,3-dimethyl- |
| inchi=1/c10h10n2/c1-7-8(2)12-10-6-4-3-5-9(10)11-7/h3-6h,1-2h |
| 2,3-dimethylquinoxaline, >=97% |
| 2,3-dimethylquinoxaline, 97% |
| CHEBI:132810 |
| 2,3-dimethyl-1,4-naphthyridine |
| D0795 |
| 2,3-dimethyl-quinoxaline |
| CHEMBL67865 |
| HMS1670C11 |
| AKOS003235661 |
| NCGC00186191-01 |
| NCGC00186191-02 |
| STK744139 |
| 4k2nh2obe9 , |
| 5-23-07-00267 (beilstein handbook reference) |
| unii-4k2nh2obe9 |
| AE-641/00127031 |
| FT-0609729 |
| AB01324042-02 |
| SCHEMBL103601 |
| DTXSID4062355 |
| mfcd00006728 |
| J-015212 |
| quinoxaline,2,3-dimethyl- |
| BS-16229 |
| 34493-67-9 |
| 10.14272/FKHNZQFCDGOQGV-UHFFFAOYSA-N.1 |
| doi:10.14272/fkhnzqfcdgoqgv-uhfffaoysa-n.1 |
| Q27225674 |
| D89719 |
| NCGC00186191-03 |
| doi:10.14272/fkhnzqfcdgoqgv-uhfffaoysa-n.2 |
| 10.14272/FKHNZQFCDGOQGV-UHFFFAOYSA-N.2 |
| A878139 |
| EN300-215112 |
| 2.3-dimethylquinoxaline |
| CS-W016201 |
| SY049291 |
| Class | Description |
|---|---|
| quinoxaline derivative | Any naphthyridine derivative that is a derivative of quinoxaline (1,4-naphthyridine). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | Mus musculus (house mouse) | IC50 (µMol) | 100.0000 | 0.0018 | 0.7552 | 9.5000 | AID161096 |
| Platelet-derived growth factor receptor alpha | Mus musculus (house mouse) | IC50 (µMol) | 100.0000 | 0.0018 | 0.8572 | 9.5000 | AID161096 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID161096 | Inhibitory activity against platelet-derived growth factor receptor tyrosine kinase in Swiss 3T3 cells | 1996 | Journal of medicinal chemistry, May-24, Volume: 39, Issue:11 | Tyrphostins. 5. Potent inhibitors of platelet-derived growth factor receptor tyrosine kinase: structure-activity relationships in quinoxalines, quinolines, and indole tyrphostins. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.52) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||