2,3,4,5,3',4',5'-heptachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

This is a highly chlorinated polychlorinated biphenyl (PCB) congener. It is of particular interest due to its environmental persistence, bioaccumulation potential, and potential toxicological effects. While its synthesis details are not readily available in public research, it likely arises through industrial processes involving the chlorination of biphenyl. Research on this specific congener is limited, but studies on other highly chlorinated PCBs have shown potential for endocrine disruption, developmental toxicity, and carcinogenic effects. Its persistence and bioaccumulation in the environment pose a concern for wildlife and human health. Studies are ongoing to understand the fate, transport, and biological impacts of highly chlorinated PCBs, with 2,3,4,5,3',4',5'-heptachlorobiphenyl serving as a representative example.'

2,3,4,5,3',4',5'-heptachlorobiphenyl: induces cytochromes P-448 & P-450; RN given refers to cpd with locants for chlorine moieties [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	38306
CHEBI ID	81525
SCHEMBL ID	2905963
MeSH ID	M0106477

Synonyms (23)

Synonym
2,3,3',4,4',5,5'-heptachloro-1,1'-biphenyl
1,1'-biphenyl, 2,3,3',4,4',5,5'-heptachloro-
2,3,3',4,4',5,5'-heptachlorobiphenyl
pcb 189
2,3,4,5,3',4',5'-heptachlorobiphenyl
1,2,3,4-tetrachloro-5-(3,4,5-trichlorophenyl)benzene
C18123
39635-31-9
bn8554xk23 ,
unii-bn8554xk23
SCHEMBL2905963
CHEBI:81525
2,3,3',4,4',5,5'-heptachloro-1,1'-biphenyl #
XUAWBXBYHDRROL-UHFFFAOYSA-N
DTXSID4074144 ,
pcb no. 189 10 microg/ml in isooctane
pcb no. 189
Q27155445
pcb no. 189 100 microg/ml in isooctane
2,3,3,4,4,5,5-heptachlorobiphenyl
3-amino-3-(2,3-dihydroxy-phenyl)-propionicacid
CS-0452064
dtxcid8039661

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

Class	Description
trichlorobenzene	Any member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.
heptachlorobiphenyl	Any polychlorobiphenyl with molecular formula C12H3Cl7.
tetrachlorobenzene	Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (15.38)	18.7374
1990's	2 (15.38)	18.2507
2000's	1 (7.69)	29.6817
2010's	5 (38.46)	24.3611
2020's	3 (23.08)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.63 (24.57)
Research Supply Index	2.64 (2.92)
Research Growth Index	5.27 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.6	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	2.05	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
pentachlorobenzene pentachlorobenzene: structure. pentachlorobenzene : A member of the class of pentachlorobenzenes that is benzene in which five of the hydrogens are replaced by chlorines. Now classed as a persistent organic pollutant under the Stockholm Convention.	1.98	1	pentachlorobenzenes	persistent organic pollutant
2,4,2',4'-tetrachlorobiphenyl 2,4,2',4'-tetrachlorobiphenyl: structure. 2,2',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.	2.13	1	dichlorobenzene; tetrachlorobiphenyl
2,4',5-trichlorobiphenyl [no description available]	2.13	1
tetrachloroethylene Tetrachloroethylene: A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.	2.11	1	chlorocarbon; chloroethenes	nephrotoxic agent
3,4,5,3',4',5'-hexachlorobiphenyl [no description available]	2.13	1	hexachlorobiphenyl; trichlorobenzene
pcb 180 PCB 180: C12-H3-Cl7	3.1	4	polychlorobiphenyl
2,2',3,5',6-pentachlorobiphenyl [no description available]	2.17	1
2,4,5,2',4',5'-hexabromobiphenyl 2,4,5,2',4',5'-hexabromobiphenyl: RN given refers to parent cpd. 2,2',4,4',5,5'-hexabromobiphenyl : A polybromobiphenyl that is biphenyl in which the hydrogens at positions 2, 2', 4, 4', 5, and 5' have been replace by bromines.	1.96	1	brominated flame retardant; polybromobiphenyl
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.13	1	oxygen hydride; oxygen radical; reactive oxygen species
heme Heme: The color-furnishing portion of hemoglobin. It is found free in tissues and as the prosthetic group in many hemeproteins.. ferroheme : Any iron(II)--porphyrin coordination complex.. ferroheme b : Heme b in which the iron has oxidation state +2.. heme : A heme is any tetrapyrrolic chelate of iron.	2.41	1

Condition	Relationship Strength	Studies
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.31	1
Deafness, Transitory [description not available]	2.1	1
Hearing Loss A general term for the complete or partial loss of the ability to hear from one or both ears.	2.1	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.96	1

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