2,3,4,5,3',4',5'-heptachlorobiphenyl

Description

2,3,4,5,3',4',5'-heptachlorobiphenyl: induces cytochromes P-448 & P-450; RN given refers to cpd with locants for chlorine moieties [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	38306
CHEBI ID	81525
SCHEMBL ID	2905963
MeSH ID	M0106477

Synonyms (23)

Synonym
2,3,3',4,4',5,5'-heptachloro-1,1'-biphenyl
1,1'-biphenyl, 2,3,3',4,4',5,5'-heptachloro-
2,3,3',4,4',5,5'-heptachlorobiphenyl
pcb 189
2,3,4,5,3',4',5'-heptachlorobiphenyl
1,2,3,4-tetrachloro-5-(3,4,5-trichlorophenyl)benzene
C18123
39635-31-9
bn8554xk23 ,
unii-bn8554xk23
SCHEMBL2905963
CHEBI:81525
2,3,3',4,4',5,5'-heptachloro-1,1'-biphenyl #
XUAWBXBYHDRROL-UHFFFAOYSA-N
DTXSID4074144 ,
pcb no. 189 10 microg/ml in isooctane
pcb no. 189
Q27155445
pcb no. 189 100 microg/ml in isooctane
2,3,3,4,4,5,5-heptachlorobiphenyl
3-amino-3-(2,3-dihydroxy-phenyl)-propionicacid
CS-0452064
dtxcid8039661

Drug Classes (3)

Class	Description
trichlorobenzene	Any member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.
heptachlorobiphenyl	Any polychlorobiphenyl with molecular formula C12H3Cl7.
tetrachlorobenzene	Any member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (13)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (15.38)	18.7374
1990's	2 (15.38)	18.2507
2000's	1 (7.69)	29.6817
2010's	5 (38.46)	24.3611
2020's	3 (23.08)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Classes	Roles
heme	[no description available]	medium	1
pcb 180	[no description available]	medium	4	polychlorobiphenyl
methanol	[no description available]	medium	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
2,2',3,5',6-pentachlorobiphenyl	[no description available]	medium	1
tetrachloroethylene	[no description available]	medium	1	chlorocarbon; chloroethenes	nephrotoxic agent
2,4,2',4'-tetrachlorobiphenyl	[no description available]	medium	1	dichlorobenzene; tetrachlorobiphenyl
hydroxyl radical	[no description available]	medium	1	oxygen hydride; oxygen radical; reactive oxygen species
3,4,5,3',4',5'-hexachlorobiphenyl	[no description available]	medium	1	hexachlorobiphenyl; trichlorobenzene
2,4',5-trichlorobiphenyl	[no description available]	medium	1
thyroxine	[no description available]	medium	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
pentachlorobenzene	[no description available]	medium	1	pentachlorobenzenes	persistent organic pollutant
2,4,5,2',4',5'-hexabromobiphenyl	[no description available]	medium	1	brominated flame retardant; polybromobiphenyl
1,2,4-trichlorobenzene	[no description available]	low	0	trichlorobenzene
2,4,5-trichlorophenoxyacetic acid	[no description available]	low	0	chlorophenoxyacetic acid; trichlorobenzene	defoliant; phenoxy herbicide; synthetic auxin
hexachlorophene	[no description available]	low	0	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug
2,4,6-trichloroanisole	[no description available]	low	0	monomethoxybenzene; trichlorobenzene
1,2,3-trichlorobenzene	[no description available]	low	0	trichlorobenzene
1,3,5-trichlorobenzene	[no description available]	low	0	trichlorobenzene
tetradifon	[no description available]	low	0	monochlorobenzenes; organochlorine acaricide; sulfone; trichlorobenzene
pcb 118	[no description available]	low	0	dichlorobenzene; pentachlorobiphenyl; trichlorobenzene
2,3,3',4,4'-pentachlorobiphenyl	[no description available]	low	0	dichlorobenzene; pentachlorobiphenyl; trichlorobenzene
2,4,6,2',4',6'-hexachlorobiphenyl	[no description available]	low	0	hexachlorobiphenyl; trichlorobenzene
2,3,5,2',3',5'-hexachlorobiphenyl	[no description available]	low	0	hexachlorobiphenyl; trichlorobenzene
3,4,5,3',4'-pentachlorobiphenyl	[no description available]	low	0	pentachlorobiphenyl; trichlorobenzene
prochloraz	[no description available]	low	0	amide fungicide; aromatic ether; conazole fungicide; imidazole fungicide; imidazoles; trichlorobenzene; ureas	antifungal agrochemical; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor; environmental contaminant; xenobiotic
4-hydroxy-2',4',6'-trichlorobiphenyl	[no description available]	low	0	biphenyls; trichlorobenzene
tetrachlorvinphos	[no description available]	low	0	alkenyl phosphate; dialkyl phosphate; organochlorine insecticide; organophosphate insecticide; trichlorobenzene	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor
3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)propan-2-yl]pyrazole-4-carboxamide	[no description available]	low	0	aromatic amide; monocarboxylic acid amide; organofluorine compound; pyrazoles; trichlorobenzene
1,2,4,5-tetrachlorobenzene	[no description available]	low	0	tetrachlorobenzene
tetrachlorophthalic anhydride	[no description available]	low	0	cyclic dicarboxylic anhydride; tetrachlorobenzene	allergen; cross-linking reagent
tecnazene	[no description available]	low	0	aromatic fungicide; C-nitro compound; tetrachlorobenzene	antifungal agrochemical
1,2,3,4-tetrachlorobenzene	[no description available]	low	0	tetrachlorobenzene
1,2,3,5-tetrachlorobenzene	[no description available]	low	0	tetrachlorobenzene
3,4,5,6-tetrachlorocatechol	[no description available]	low	0	chlorocatechol; tetrachlorobenzene
tetrachloroisophthalonitrile	[no description available]	low	0	aromatic fungicide; dinitrile; tetrachlorobenzene	antifungal agrochemical
4,5,6,7-tetrachlorophthalide	[no description available]	low	0	gamma-lactone; organic heterobicyclic compound; propan-1-ol; tetrachlorobenzene	antifungal agrochemical; melanin synthesis inhibitor
2,3,4,5-tetrachlorobiphenyl	[no description available]	low	0	tetrachlorobenzene; tetrachlorobiphenyl
2,3,5,6-tetrachlorobiphenyl	[no description available]	low	0	tetrachlorobenzene; tetrachlorobiphenyl
2,3,3',4,4',5-hexachlorobiphenyl	[no description available]	low	0	dichlorobenzene; hexachlorobiphenyl; tetrachlorobenzene
2,3,4,4'5-pentachlorobiphenyl	[no description available]	low	0	monochlorobenzenes; pentachlorobiphenyl; tetrachlorobenzene
2,3,5,6-tetrachlorohydroquinone	[no description available]	low	0	chlorohydroquinones; tetrachlorobenzene
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl	[no description available]	low	0	biphenyls; tetrachlorobenzene

Condition	Relationship Strength	Studies
Body Weight	low	1
Deafness, Transitory	low	1
Hearing Impairment	low	1
Hearing Loss	low	1
Hearing Loss, Transitory	low	1
Hypoacusis	low	1
Pregnancy	low	1
Transitory Hearing Loss	low	1

Research Highlights

Safety/Toxicity (1)

Article	Year
Indicator parameters for PCDD/F as a possible means to monitor emissions of toxicity equivalents from waste incinerators. Central European journal of public health, Volume: 1, Issue: 2	1993
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

Article	Year
Bioavailability of soil-borne polybrominated biphenyls ingested by farm animals. Journal of toxicology and environmental health, Volume: 16, Issue: 3-4	1985
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]