Page last updated: 2024-12-06

2,3,4,5,3',4',5'-heptachlorobiphenyl

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

This is a highly chlorinated polychlorinated biphenyl (PCB) congener. It is of particular interest due to its environmental persistence, bioaccumulation potential, and potential toxicological effects. While its synthesis details are not readily available in public research, it likely arises through industrial processes involving the chlorination of biphenyl. Research on this specific congener is limited, but studies on other highly chlorinated PCBs have shown potential for endocrine disruption, developmental toxicity, and carcinogenic effects. Its persistence and bioaccumulation in the environment pose a concern for wildlife and human health. Studies are ongoing to understand the fate, transport, and biological impacts of highly chlorinated PCBs, with 2,3,4,5,3',4',5'-heptachlorobiphenyl serving as a representative example.'

2,3,4,5,3',4',5'-heptachlorobiphenyl: induces cytochromes P-448 & P-450; RN given refers to cpd with locants for chlorine moieties [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID38306
CHEBI ID81525
SCHEMBL ID2905963
MeSH IDM0106477

Synonyms (23)

Synonym
2,3,3',4,4',5,5'-heptachloro-1,1'-biphenyl
1,1'-biphenyl, 2,3,3',4,4',5,5'-heptachloro-
2,3,3',4,4',5,5'-heptachlorobiphenyl
pcb 189
2,3,4,5,3',4',5'-heptachlorobiphenyl
1,2,3,4-tetrachloro-5-(3,4,5-trichlorophenyl)benzene
C18123
39635-31-9
bn8554xk23 ,
unii-bn8554xk23
SCHEMBL2905963
CHEBI:81525
2,3,3',4,4',5,5'-heptachloro-1,1'-biphenyl #
XUAWBXBYHDRROL-UHFFFAOYSA-N
DTXSID4074144 ,
pcb no. 189 10 microg/ml in isooctane
pcb no. 189
Q27155445
pcb no. 189 100 microg/ml in isooctane
2,3,3,4,4,5,5-heptachlorobiphenyl
3-amino-3-(2,3-dihydroxy-phenyl)-propionicacid
CS-0452064
dtxcid8039661
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (3)

ClassDescription
trichlorobenzeneAny member of the class of chlorobenzenes carrying three chloro substituents at unspecified positions.
heptachlorobiphenylAny polychlorobiphenyl with molecular formula C12H3Cl7.
tetrachlorobenzeneAny member of the class of chlorobenzenes carrying four chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (15.38)18.7374
1990's2 (15.38)18.2507
2000's1 (7.69)29.6817
2010's5 (38.46)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]