Compounds > 2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)
Page last updated: 2024-12-06
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)
Description
Also known as 2,2'-Methylenebis(4-chloro-3-methyl-6-tert-butylphenol), 2,2-Methylenebis(4-chloro-3-(1-methylethyl)-phenol), and Di(4-chloro-3-methyl-6-tert-butylphenyl)methane, this compound is a synthetic phenolic antioxidant commonly used as a stabilizer in polymers. It is a white to light-yellow solid that is insoluble in water but soluble in organic solvents. The compound is synthesized by reacting 4-chloro-3-methylphenol with formaldehyde in the presence of a catalyst. 2,2-Methylenebis(4-chloro-3-methyl-isopropylphenol) is a powerful antioxidant and is used in various applications, including polymers, rubber, lubricants, and foods. It prevents the degradation of these materials by inhibiting oxidation reactions. Its primary use is as a stabilizer in polymers, helping to prevent degradation and improve the lifespan of the material. It is commonly found in plastics, rubber, and adhesives. The effectiveness of 2,2-Methylenebis(4-chloro-3-methyl-isopropylphenol) as an antioxidant is attributed to its ability to donate hydrogen atoms to free radicals, thus preventing chain reactions that lead to degradation. Studies on this compound focus on its antioxidant properties, environmental fate, and toxicity. The compound has been found to be toxic to aquatic organisms, and its potential environmental impact is being investigated. Research is also ongoing to develop more sustainable and environmentally friendly alternatives to traditional antioxidants.'
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol): structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
PubMed CID | 71878 |
CHEMBL ID | 2107655 |
CHEBI ID | 177790 |
SCHEMBL ID | 70634 |
MeSH ID | M0527012 |
Synonyms (34)
Synonym |
CHEBI:177790 |
biclotymol |
4-chloro-2-[(5-chloro-2-hydroxy-6-methyl-3-propan-2-ylphenyl)methyl]-3-methyl-6-propan-2-ylphenol |
thymol, 2,2'-methylenebis[6-chloro- |
4-chloro-2-[(5-chloro-2-hydroxy-3-isopropyl-6-methyl-phenyl)methyl]-6-isopropyl-3-methyl-phenol |
biclotymol (inn) |
15686-33-6 |
D07527 |
hexaspray (tn) |
6,6'-dichlor-2,2'-methylendithymol |
biclotymolum |
w4k0ae8xw9 , |
2,2'-methylenebis(6-chlorothymole) |
biclotymolum [inn-latin] |
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol) |
biclotymol [inn:dcf] |
unii-w4k0ae8xw9 |
einecs 239-771-5 |
biclotymol [who-dd] |
biclotymol [mart.] |
biclotymol [inn] |
CHEMBL2107655 |
hexaspray |
c21h26cl2o2 |
SCHEMBL70634 |
6,6'-methylenebis(4-chloro-2-isopropyl-5-methylphenol) |
DTXSID90166144 |
phenol, 2,2'-methylenebis[4-chloro-3-methyl-6-(1-methylethyl)- |
AKOS027380999 |
Q2901642 |
mfcd00865128 |
DS-13173 |
CS-0059759 |
W17157 |
Drug Classes (1)
Class | Description |
diarylmethane | Any compound containing two aryl groups connected by a single C atom. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (6)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 5 (83.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 13.01
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 13.01 (24.57) | Research Supply Index | 2.20 (2.92) | Research Growth Index | 5.21 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 1 (14.29%) | 5.53% |
Reviews | 1 (14.29%) | 6.00% |
Case Studies | 1 (14.29%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 4 (57.14%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |