Page last updated: 2024-12-06

2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Also known as 2,2'-Methylenebis(4-chloro-3-methyl-6-tert-butylphenol), 2,2-Methylenebis(4-chloro-3-(1-methylethyl)-phenol), and Di(4-chloro-3-methyl-6-tert-butylphenyl)methane, this compound is a synthetic phenolic antioxidant commonly used as a stabilizer in polymers. It is a white to light-yellow solid that is insoluble in water but soluble in organic solvents. The compound is synthesized by reacting 4-chloro-3-methylphenol with formaldehyde in the presence of a catalyst. 2,2-Methylenebis(4-chloro-3-methyl-isopropylphenol) is a powerful antioxidant and is used in various applications, including polymers, rubber, lubricants, and foods. It prevents the degradation of these materials by inhibiting oxidation reactions. Its primary use is as a stabilizer in polymers, helping to prevent degradation and improve the lifespan of the material. It is commonly found in plastics, rubber, and adhesives. The effectiveness of 2,2-Methylenebis(4-chloro-3-methyl-isopropylphenol) as an antioxidant is attributed to its ability to donate hydrogen atoms to free radicals, thus preventing chain reactions that lead to degradation. Studies on this compound focus on its antioxidant properties, environmental fate, and toxicity. The compound has been found to be toxic to aquatic organisms, and its potential environmental impact is being investigated. Research is also ongoing to develop more sustainable and environmentally friendly alternatives to traditional antioxidants.'

2,2-methylenebis(4-chloro-3-methyl-isopropylphenol): structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID71878
CHEMBL ID2107655
CHEBI ID177790
SCHEMBL ID70634
MeSH IDM0527012

Synonyms (34)

Synonym
CHEBI:177790
biclotymol
4-chloro-2-[(5-chloro-2-hydroxy-6-methyl-3-propan-2-ylphenyl)methyl]-3-methyl-6-propan-2-ylphenol
thymol, 2,2'-methylenebis[6-chloro-
4-chloro-2-[(5-chloro-2-hydroxy-3-isopropyl-6-methyl-phenyl)methyl]-6-isopropyl-3-methyl-phenol
biclotymol (inn)
15686-33-6
D07527
hexaspray (tn)
6,6'-dichlor-2,2'-methylendithymol
biclotymolum
w4k0ae8xw9 ,
2,2'-methylenebis(6-chlorothymole)
biclotymolum [inn-latin]
2,2-methylenebis(4-chloro-3-methyl-isopropylphenol)
biclotymol [inn:dcf]
unii-w4k0ae8xw9
einecs 239-771-5
biclotymol [who-dd]
biclotymol [mart.]
biclotymol [inn]
CHEMBL2107655
hexaspray
c21h26cl2o2
SCHEMBL70634
6,6'-methylenebis(4-chloro-2-isopropyl-5-methylphenol)
DTXSID90166144
phenol, 2,2'-methylenebis[4-chloro-3-methyl-6-(1-methylethyl)-
AKOS027380999
Q2901642
mfcd00865128
DS-13173
CS-0059759
W17157
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
diarylmethaneAny compound containing two aryl groups connected by a single C atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's5 (83.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.01 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.21 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (14.29%)5.53%
Reviews1 (14.29%)6.00%
Case Studies1 (14.29%)4.05%
Observational0 (0.00%)0.25%
Other4 (57.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]