Compounds > 2,2,3,3-tetramethylcyclopropanecarbonylurea
Page last updated: 2024-11-12

2,2,3,3-tetramethylcyclopropanecarbonylurea

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,2,3,3-tetramethylcyclopropanecarbonylurea: has anticonvulsant activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10176413
CHEMBL ID184676
SCHEMBL ID1577776
MeSH IDM0471651

Synonyms (7)

Synonym
CHEMBL184676
2,2,3,3-tetramethylcyclopropanecarbonylurea
AKOS014777967
SCHEMBL1577776
752250-12-7
n-carbamoyl-2-2-3-3-tetramethylcyclopropane-1-carboxamide
n-carbamoyl-2,2,3,3-tetramethylcyclopropane-1-carboxamide

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" administration, the peak plasma concentration (C(max)) obtained 45 min after dosing was 15."( Pharmacokinetics and metabolism of a new potent antiepileptic drug, 2,2,3,3-tetramethycyclopropanecarbonylurea, in rats.
Bialer, M; Britzi, M; Gibson, D; Sobol, E; Winkler, I; Yagen, B, 2005)		0.33
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (47)

Assay IDTitleYearJournalArticle
AID250651Anticonvulsant activity after oral administration of 50 mg/kg dose after 1 hr in rats; - means No protection2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250614Anticonvulsant activity after oral administration of 50 mg/kg dose after 4 hr in rats; -means No protection2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253405Anti convulsant activity administered intra peritoneally to mouse for toxicity at 4 hr with dose of 300 mg/kg; 1/2= No of animals exhibiting toxicity /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250916Anticonvulsant activity after oral administration of 30 mg/kg dose after 30 min in rats; ++ means 50% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251081Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 0.5 hr after the drug administered with dose of 300 mg/kg; 1/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251048Anti convulsant activity administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr with dose of 300 mg/kg; 3/5= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250874Anticonvulsant activity after oral administration of 30 mg/kg dose after 4 hr in rats; + means 25% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253400Anti convulsant activity administered intra peritoneally to mouse for toxicity at 4 hr with dose of 100 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250799Quantitative Anticonvulsant activity administered orally to rat for protective index in subcutaneous metrazol test2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253412Anti convulsant activity administered intra peritoneally to mouse for toxicity at 0.5 hr with dose of 300 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID247106Quantitative Anticonvulsant activity administered intraperitoneally to mouse for maximal electro shock test; The interval in parenthesis stands for 95% confidence interval2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253118Toxicity after oral administration of 30 mg/kg dose in rats; - means No toxicity2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253383Quantitative Anticonvulsant activity administered intraperitoneally to mouse for toxicity2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250917Anticonvulsant activity after oral administration of 50 mg/kg dose after 30 min in rats; ++ means 50% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253409Anti convulsant activity administered intra peritoneally to mouse for toxicity at 0.5 hr with dose of 100 mg/kg; 0/8= No of animals exhibiting toxicity /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251051Anti convulsant activity administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 h with dose of 300 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID249464Quantitative Anticonvulsant activity administered intraperitoneally to mouse for protective index in maximal electro shock test;TD50/ED502004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID249456Quantitative Anticonvulsant activity administered orally to rat for protective index in maximal electro shock test;TD50/ED502004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID247017Quantitative Anticonvulsant activity administered intraperitoneally to mouse for subcutaneous metrazol test2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250892Anticonvulsant activity after oral administration of 30 mg/kg dose after 1 hr in rats; +++ means 75% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253391Toxicity after oral administration of 50 mg/kg dose in rats; - means No toxicity2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250653Anticonvulsant activity after oral administration of 50 mg/kg dose after 2 hr in rats; - means No protection2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250891Anticonvulsant activity after oral administration of 30 mg/kg dose after 15 min in rats;+means 25% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251082Anti convulsant activity administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID353915Protective index, ratio of TD50 for albino Sprague-Dawley rat to ED50 for scMet-induced albino Sprague-Dawley rat seizure model2009Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
AID251079Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 0.5 hr after the drug administered with dose of 100 mg/kg; 3/3= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251075Anti convulsant activity administered intra peritoneally to mouse for subcutaneous metrazol test at 4 hr after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251069Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 4 hr after the drug administered with dose of 100 mg/kg; 0/3= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251074Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 0.5 h after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID353913Protective index, ratio of TD50 for albino Sprague-Dawley rat to ED50 for maximal electroshock-induced albino Sprague-Dawley rat seizure model2009Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
AID251068Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 4 hr after the drug administered with dose of 100 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID235935Anticonvulsant activity administered intraperitoneally to mouse for toxicity at 4 hr with dose of 30 mg/kg2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253408Anti convulsant activity administered intra peritoneally to mouse for toxicity at 0.5 hr with dose of 30 mg/kg; 0/4= No of animals exhibiting toxicity /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID250906Anticonvulsant activity after oral administration of 30 mg/kg dose after 2 hr in rats; ++++ means 100% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253380Quantitative Anticonvulsant activity administered orally to rat for toxicity2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID353916Neurotoxicity in po dosed albino Sprague-Dawley rat assessed as minimal motor impairment2009Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
AID237333Calculated partition coefficient (clogP)2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID353912Anticonvulsant activity in po dosed albino Sprague-Dawley rat assessed as protection against maximal electroshock-induced seizures2009Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
AID247097Quantitative Anticonvulsant activity administered orally to rat at maximal electro shock test; the interval in parenthesis stands for 95% confidence interval2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID251073Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 4 hr after the drug administered with dose of 300 mg/kg; 1/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID246969Quantitative Anticonvulsant activity administered orally to rat for subcutaneous metrazol test2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID244489Quantitative Anticonvulsant activity administered intraperitoneally to mouse for protective index in subcutaneous metrazol test2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID353914Anticonvulsant activity in po dosed albino Sprague-Dawley rat assessed as protection against scMet-induced seizures2009Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
AID251049Anti convulsant activity administered intra peritoneally to mouse for subcutaneous metrazol test at 0.5 hr with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID253137Anticonvulsant activity after oral administration of 50 mg/kg dose after 15 min in rats; +++ means 75% of the animals protected2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
AID408763Anticonvulsant activity against maximal electroshock-induced seizures in orally dosed rat model2008Bioorganic & medicinal chemistry, Jun-01, Volume: 16, Issue:11
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
AID251067Anti convulsant activity administered intra peritoneally to mouse at maximal electroshock test at 4 hr after the drug administered with dose of 30 mg/kg; 0/1= No of animals protected /No of animals tested2004Journal of medicinal chemistry, Aug-12, Volume: 47, Issue:17
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		7.9440isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
valproic acid
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.. valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.		7.9540branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
mexiletine
Mexiletine: Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.. mexiletine : An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.		2.0410aromatic ether;
primary amino compound		anti-arrhythmia drug
zonisamide
Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.. zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.		2.04101,2-benzoxazoles;
sulfonamide		anticonvulsant;
antioxidant;
central nervous system drug;
protective agent;
T-type calcium channel blocker
pentylenetetrazole
Pentylenetetrazole: A pharmaceutical agent that displays activity as a central nervous system and respiratory stimulant. It is considered a non-competitive GAMMA-AMINOBUTYRIC ACID antagonist. Pentylenetetrazole has been used experimentally to study seizure phenomenon and to identify pharmaceuticals that may control seizure susceptibility.. pentetrazol : An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.		2.0210organic heterobicyclic compound;
organonitrogen heterocyclic compound
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		2.0410isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
dipropylacetamide
dipropylacetamide: structure. valpromide : A fatty amide derived from valproic acid.		2.0510fatty amidegeroprotector;
metabolite;
teratogenic agent
2,2,3,3-tetramethylcyclopropane carboxamide
2,2,3,3-tetramethylcyclopropane carboxamide: structure in first source		2.7330
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure
[description not available]		02.7230
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.7230
Aura
[description not available]		02.0510
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		02.0510
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)		02.0510
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.0310