2,2,2-trifluoroethanesulfonyl chloride profile

2,2,2-Trifluoroethanesulfonyl chloride (also known as triflic chloride) is a colorless liquid with a pungent odor. It is a strong electrophile and is commonly used as a reagent in organic synthesis. It is synthesized by reacting trifluoromethanesulfonic acid (triflic acid) with thionyl chloride. Triflic chloride is a versatile reagent used in various reactions, including:
- **Fluorination:** It can be used to introduce fluorine atoms into organic molecules.
- **Sulfonylation:** It is a common reagent for the sulfonylation of alcohols and amines.
- **C-H activation:** It can be used to activate C-H bonds, allowing for the functionalization of hydrocarbons.
- **Formation of triflates:** Triflic chloride reacts with alcohols to form triflates, which are excellent leaving groups in nucleophilic substitution reactions.
Triflic chloride is often studied because of its unique reactivity and its ability to form stable, highly reactive intermediates. It is a key reagent in many important chemical processes, including the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals.'
```

ID Source	ID
PubMed CID	74242
SCHEMBL ID	17744
MeSH ID	M0101672

Synonym
ethanesulfonyl chloride, 2,2,2-trifluoro-
(2,2,2-trifluoroethyl)sulphonyl chloride
einecs 216-713-7
1648-99-3
2,2,2-trifluoroethanesulfonyl chloride, 99%
tresyl chloride
2,2,2-trifluoroethanesulfonyl chloride
cxchekcrjqrvng-uhfffaoysa-
inchi=1/c2h2clf3o2s/c3-9(7,8)1-2(4,5)6/h1h2
A810600
2,2,2-trifluoroethanesulfonyl chloride; (2,2,2-trifluoroethyl)sulphonyl chloride
2,2,2-trifluoroethane-1-sulfonyl chloride
EN300-72772
AKOS006223654
ethanesulfonylchloride, 2,2,2-trifluoro-
FT-0609033
AB00878
2,2,2-trifluoroethylsulfonyl chloride
SCHEMBL17744
2,2,2-trifluoroethane sulfonyl chloride
2,2,2 trifluoroethane sulfonyl chloride
2,2,2-trifluoro-ethanesulfonyl chloride
2,2,2-trifluoroethanesulfonylchloride
cf3ch2so2cl
2,2,2,-trifluoroethanesulfonyl chloride
trifluoroethanesulfonyl chloride
trifluoroethylsulfonyl chloride
2,2,2-trifluoroethanesulphonyl chloride
2,2,2-trifluoroethane sulfonylchloride
2,-2,-2-trifluoroethanesulfonyl chloride
DTXSID00167809
mfcd00007458
c2h2clf3o2s
Z414834394
J-010169
BS-13138
BP-24003
AT12087
2,2,2-trifluoroethane-sulfonic acid, chloride
ethanesulfonylchloride,2,2,2-trifluoro-

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (25.93)	18.7374
1990's	7 (25.93)	18.2507
2000's	8 (29.63)	29.6817
2010's	4 (14.81)	24.3611
2020's	1 (3.70)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	31 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.11	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	1.96	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	1.96	1	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
divinyl sulfone divinyl sulfone: cross-linking reagent for agarose gels. divinyl sulfone : A sulfone compound having two S-vinyl substituents.	1.98	1	sulfone	cross-linking reagent
cyanuric chloride cyanuric chloride : A chloro-1,3,5-triazine in which the triazine ring is substituted on each carbon by chlorine. Its main use is in the preparation of the triazine-class pesticides.	2	1	chloro-1,3,5-triazine; organochlorine compound	cross-linking reagent
hydrazine diamine : Any polyamine that contains two amino groups.	1.97	1	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
cyanogen bromide Cyanogen Bromide: Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.	2.9	4
1,4-bis(2,3-epoxypropoxy)butane [no description available]	1.98	1
molybdenum Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.	1.99	1	chromium group element atom	micronutrient
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	3.15	5	titanium group element atom
chromium Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.. chromium ion : An chromium atom having a net electric charge.. chromium atom : A chromium group element atom that has atomic number 24.	1.99	1	chromium group element atom; metal allergen	micronutrient
n,n-carbonyldiimidazole [no description available]	1.96	1
n-hydroxysuccinimide N-hydroxysuccinimide: structure	2.42	2
cobalt Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.	1.99	1	cobalt group element atom; metal allergen	micronutrient
sesquiterpenes [no description available]	1.97	1
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.05	1
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.11	1	organic sodium salt	detergent; protein denaturant
alpha-chymotrypsin Chymotrypsin: A serine endopeptidase secreted by the pancreas as its zymogen, CHYMOTRYPSINOGEN and carried in the pancreatic juice to the duodenum where it is activated by TRYPSIN. It selectively cleaves aromatic amino acids on the carboxyl side.	1.97	1
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	1.96	1	carbon group element atom; metalloid atom; nonmetal atom
ganglioside, gd2 [no description available]	2.05	1
sepharose agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.	3.23	6
phytosterols Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.	2.05	1
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	2.65	3	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.11	1
t-2 toxin T-2 Toxin: A potent mycotoxin produced in feedstuffs by several species of the genus FUSARIUM. It elicits a severe inflammatory reaction in animals and has teratogenic effects.. T-2 toxin : A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.	1.97	1
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	1.96	1

Condition	Relationship Strength	Studies
Adenocarcinoma, Basal Cell [description not available]	1.99	1
Cancer of Colon [description not available]	1.99	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.99	1
Colonic Neoplasms Tumors or cancer of the COLON.	1.99	1

2,2,2-trifluoroethanesulfonyl chloride

Cross-References

Synonyms (40)

Research

Studies (27)

Market Indicators

Research Demand Index: 11.02

Study Types