Compounds > 2,2'-dicarbomethoxyamino-5-5'-dibenzimidazolyl ketone
Page last updated: 2024-12-07

2,2'-dicarbomethoxyamino-5-5'-dibenzimidazolyl ketone

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Description

2,2'-dicarbomethoxyamino-5-5'-dibenzimidazolyl ketone: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128082
CHEMBL ID24334
MeSH IDM0173487

Synonyms (9)

Synonym
compound 82-437
CHEMBL24334
methyl n-[6-[2-(methoxycarbonylamino)-3h-benzimidazole-5-carbonyl]-1h-benzimidazol-2-yl]carbamate
carbamic acid, (carbonylbis(1h-benzimidazole-5,2-diyl))bis-, dimethyl ester
2,2'-dicarbomethoxyamino-5-5'-dibenzimidazolyl ketone
102342-72-3
cdri 82/437
compound 82/437;2,2'-dicarbomethoxyamino-5-5'-dibenzimidazolyl ketone
DTXSID80144931
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (42)

Assay IDTitleYearJournalArticle
AID108405Filaricidal activity against Brugia malayi in Mastomys at a dosage of 50 mg/kg x 5 administered intraperitoneally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID139570Anthelmintic activity against Syphacia obvelata in mice at a dose of 100x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108421Filaricidal activity against Brugia malayi in Mastomys at a dosage of 50 mg/kg x 5 administered intraperitoneally at a day of 911986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID195824Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 100 mg/kg x 5 administered orally at a day of 211986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108416Filaricidal activity against Brugia malayi in Mastomys at a dosage of 200 mg/kg x 5 administered orally at a day of 911986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108429Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 25 mg/kg x 5 administered subcutaneous at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID87115Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 12.5x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108420Filaricidal activity against Brugia malayi in Mastomys at a dosage of 50 mg/kg x 5 administered intraperitoneally at a day of 81986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID84180Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 25x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108428Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 25 mg/kg x 5 administered subcutaneous at a day of 211986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108417Filaricidal activity against Brugia malayi in Mastomys at a dosage of 50 mg/kg x 5 administered intraperitoneally at a day of 211986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108424Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 150 mg/kg x 5 administered orally at a day of 81986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108408Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 25 mg/kg x 5 administered subcutaneous1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID190243Anthelmintic activity against Hymenolepis nana in rats at a dose of 50x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108411Filaricidal activity against Brugia malayi in Mastomys at a dosage of 200 mg/kg x 5 administered intraperitoneally at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108430Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 25 mg/kg x 5 administered subcutaneous at a day of 81986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID139571Anthelmintic activity against Syphacia obvelata in mice at a dose of 25x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID84181Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 50x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID87113Anthelmintic activity against Ancylostoma ceylanicum (hook worm) in hamsters at a dose of 50x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID139572Anthelmintic activity against Syphacia obvelata in mice at a dose of 50x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID190241Anthelmintic activity against Hymenolepis nana in rats at a dose of 250x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID87116Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 25x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108415Filaricidal activity against Brugia malayi in Mastomys at a dosage of 200 mg/kg x 5 administered orally at a day of 81986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108419Filaricidal activity against Brugia malayi in Mastomys at a dosage of 50 mg/kg x 5 administered intraperitoneally at a day of 631986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID84182Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 6.25 x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108412Filaricidal activity against Brugia malayi in Mastomys at a dosage of 200 mg/kg x 5 administered orally at a day of 211986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108406Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 150 mg/kg x 5 administered orally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID195827Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 10 mg/kg x 5 administered intraperitoneally at a day of 211986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108414Filaricidal activity against Brugia malayi in Mastomys at a dosage of 200 mg/kg x 5 administered orally at a day of 631986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID190240Anthelmintic activity against Hymenolepis nana in rats at a dose of 100x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID195826Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 100 mg/kg x 5 administered orally at a day of 81986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID192892Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 10 mg/kg x 5 administered intraperitoneally at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108422Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 150 mg/kg x 5 administered orally at a day of 211986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108404Filaricidal activity against Brugia malayi in Mastomys at a dosage of 200 mg/kg x 5 administered orally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID195825Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 100 mg/kg x 5 administered orally at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108423Filaricidal activity against Dipetalonema viteae in Mastomys at a dosage of 150 mg/kg x 5 administered orally at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID195829Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 10 mg/kg x 5 administered intraperitoneally at a day of 81986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID84179Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 12.5x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID87117Anthelmintic activity against Ancylostoma ceylanicum in hamsters at a dose of 6.25 x1 mg/kg administered perorally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID108418Filaricidal activity against Brugia malayi in Mastomys at a dosage of 50 mg/kg x 5 administered intraperitoneally at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID195828Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 10 mg/kg x 5 administered intraperitoneally at a day of 421986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
AID192891Filaricidal activity against Litomosoides carinii in cotton rats at a dosage of 100 mg/kg x 5 administered orally1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Studies in potential filaricides. 18. Synthesis of 2,2'-disubstituted 5,5'-dibenzimidazolyl ketones and related compounds as potential anthelmintics.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.74

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.74 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.74)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diethylcarbamazine
Diethylcarbamazine: An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.		2.6630N-carbamoylpiperazine;
N-methylpiperazine
mebendazole
Mebendazole: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.. mebendazole : A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.		2.3720aromatic ketone;
benzimidazoles;
carbamate ester		antinematodal drug;
microtubule-destabilising agent;
tubulin modulator
d-alpha tocopherol
Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.		1.9810alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Bertielliasis
[description not available]		01.9610
Elaeophoriasis
[description not available]		02.3720
Bunostomiasis
[description not available]		01.9610
Filariasis
Infections with nematodes of the superfamily FILARIOIDEA. The presence of living worms in the body is mainly asymptomatic but the death of adult worms leads to granulomatous inflammation and permanent fibrosis. Organisms of the genus Elaeophora infect wild elk and domestic sheep causing ischemic necrosis of the brain, blindness, and dermatosis of the face.		02.3720
Hookworm Infections
Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.		01.9610
Setariasis
Infection with nematodes of the genus Setaria. This condition is usually seen in cattle and equines and is of little pathogenic significance, although migration of the worm to the eye may lead to blindness.		01.9810
Dipetalonema Infections
Infections with nematodes of the genus DIPETALONEMA.		01.9810