Compounds > 2,2',4,5'-tetrabromodiphenyl ether
Page last updated: 2024-11-12

2,2',4,5'-tetrabromodiphenyl ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID15509892
CHEBI ID81583
SCHEMBL ID16678817
MeSH IDM0574275

Synonyms (16)

Synonym
243982-82-3
C18204
pbde 49
2,2',4,5'-tetrabromodiphenyl ether
bde 49
d24364111z ,
unii-d24364111z
CHEBI:81583
benzene, 1,4-dibromo-2-(2,4-dibromophenoxy)-
SCHEMBL16678817
J-015496
DTXSID90873927
Q27155473
1,4-dibromo-2-(2,4-dibromophenoxy)benzene
pbde no. 49
benzene, 1,4-dibromo-2-(2,4-dibromophenoxy)-; 1,4-dibromo-2-(2,4-dibromophenoxy)benzene; 2,2',4,5'-tetrabromodiphenyl ether; bde 49; pbde 49; 2,2',4,5'-tetrabde

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Both PBDEs were toxic to mitochondria: BDE-47 and BDE-99 concentrations equal to or higher than 25 and 50 µM, respectively, modified all the parameters used to assess mitochondrial bioenergetics, which culminated in ATP depletion."( Toxicity of brominated flame retardants, BDE-47 and BDE-99 stems from impaired mitochondrial bioenergetics.
Dorta, DJ; Pazin, M; Pereira, LC, 2015)		0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
organobromine compoundA compound containing at least one carbon-bromine bond.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tetrabromobisphenol a
tetrabromobisphenol A: a brominated flame retardant. 3,3',5,5'-tetrabromobisphenol A : A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant.		2.1710brominated flame retardant;
bromobisphenol
decabromobiphenyl ether
decabromobiphenyl ether: a flame retardant. decabromodiphenyl ether : A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.		2.5720polybromodiphenyl etherneurotoxin
bde 206
2,2',3,3',4,4',5,5',6-nonabromodiphenyl ether: structure in first source		2.1510
2,2',4,4'-tetrabromodiphenyl ether
[no description available]		3.6680aromatic ether;
organobromine compound
bde 207
2,2',3,3',4,4',5,6,6'-nonabromodiphenyl ether: structure in first source		2.1510
bde 197
2,2',3,3',4,4',6,6'-octabromodiphenyl ether: a component of DE-79, a technical octabromo diphenyl ether mixture		2.1510
tribromodiphenyl ether 28
4-bromophenyl 2,4-dibromophenyl ether : A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, and 4' positions have been replaced by bromines.		2.5420polybromodiphenyl ether
hexabromodiphenyl ether 154
2,2',4,4',5,6'-hexabromodiphenyl ether: structure in first source		2.5420aromatic ether;
organobromine compound
bde 183
2,2',3,4,4',5',6-heptabromodiphenyl ether: a polybrominated diphenyl ether compound		2.1510aromatic ether;
organobromine compound
ConditionIndicatedRelationship StrengthStudiesTrials