Compounds > 2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine
Page last updated: 2024-09-26

2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine

Cross-References

ID SourceID
PubMed CID10897041
CHEMBL ID3144379
MeSH IDM0073851

Synonyms (2)

Synonym
2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine
CHEMBL3144379

Drug Classes (2)

ClassDescription
purinesA class of imidazopyrimidines that consists of purine and its substituted derivatives.
nucleoside analogueAn analogue of a nucleoside, being an N-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID55332Percent inhibition of DNA synthesis ([Me-3H] thymidine incorporation) at 50 uM concentration1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action.
AID164131Percent inhibition of protein synthesis ([35S]methionine incorporation) at 50 uM concentration1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action.
AID55333Percent inhibition of DNA synthesis ([Me-3H] thymidine incorporation) at 5 uM concentration1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action.
AID164132Percent inhibition of protein synthesis ([35S]methionine incorporation) at 5 uM concentration1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Structure--activity relationships for and potentiation of the antimitogenic activity of 2-5A core derived from 2-5A, a mediator of interferon action.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (42.86)18.7374
1990's6 (42.86)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
adenosine monophosphate[no description available]medium30adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
adenylyl-(3'-5')-adenosine[no description available]medium10
oligonucleotides[no description available]medium20
2'-deoxythymidylyl-(3'-5')-2'-deoxyadenosine[no description available]medium10
adenine[no description available]medium506-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
vitamin k 3[no description available]medium101,4-naphthoquinones;
vitamin K		angiogenesis inhibitor;
antineoplastic agent;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
human urinary metabolite;
nutraceutical
adenosine monophosphate-adenosine[no description available]medium10
2'-deoxy-5'-adenosine monophosphate[no description available]medium102'-deoxyadenosine 5'-phosphate;
purine 2'-deoxyribonucleoside 5'-monophosphate		fundamental metabolite
6-chloropurine riboside[no description available]medium10
histidine[no description available]medium10amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
inosinic acid[no description available]medium10inosine phosphate;
purine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
6-chloropurine 9-beta-d-ribofuranosyl 5'-monophosphate[no description available]medium10
bohemine[no description available]low00purinesEC 2.7.11.22 (cyclin-dependent kinase) inhibitor
8-chlorotheophylline[no description available]low00organochlorine compound;
purines		central nervous system stimulant
2-fluoroadenine[no description available]low00organofluorine compound;
purines		antineoplastic agent
cytidylyl-3',5'-adenosine[no description available]low00nucleoside analogue;
purines
uridylyl-(3'-5')-adenosine[no description available]low00nucleoside analogue;
purines
1,n(6)-ethenodeoxyadenosine[no description available]low00purines
adenylyl-(2'-5')-uridine[no description available]low00nucleoside analogue;
purines
2-(4-morpholinoanilino)-6-cyclohexylaminopurine[no description available]low00morpholines;
purines;
secondary amino compound;
tertiary amino compound		adenosine A3 receptor antagonist;
antineoplastic agent;
Aurora kinase inhibitor;
cell dedifferentiation agent
(2R,3S,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-oxolanol[no description available]low003'-deoxyribonucleoside;
purines
mercaptopurine[no description available]low00aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
benzoic acid [5-(6-benzamido-9-purinyl)-3-fluoro-4-hydroxy-2-oxolanyl]methyl ester[no description available]low003'-deoxyribonucleoside;
purines
6-mercapto-9-(tetrahydro-2-furyl)purine[no description available]low00purines;
thiocarbonyl compound
2-amino-9-pentyl-3H-purine-6-thione[no description available]low00purines;
thiocarbonyl compound
9-cyclopentyl-3H-purine-6-thione[no description available]low00purines;
thiocarbonyl compound
purmorphamine[no description available]low00aromatic ether;
morpholines;
purines;
secondary amino compound		osteogenesis regulator;
SMO receptor agonist
6-methylpurine[no description available]low00purinesEC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
6-chloropurine[no description available]low00purines
idelalisib[no description available]low00aromatic amine;
organofluorine compound;
purines;
quinazolines;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
agrocin 84[no description available]low00purines
4-[[9-[(3R)-3-oxolanyl]-8-(2,4,6-trifluoroanilino)-2-purinyl]amino]-1-cyclohexanol[no description available]low00purines
valganciclovir[no description available]low00L-valyl ester;
purines		antiviral drug;
prodrug
5-(4-methoxyphenyl)-6-sulfanylidene-1,2-dihydropyrazolo[3,4-d]pyrimidin-4-one[no description available]low00organosulfur compound;
purines
guanylyl-(3'-5')-guanosine[no description available]low00nucleoside analogue;
purines
2'-deoxyguanylyl-(3'-5')-2'-deoxycytidine[no description available]low00nucleoside analogue;
purines
guanine ribonucleotidyl-(3'-5')-adenosine[no description available]low00nucleoside analogue;
purines
flucytosine[no description available]low00aminopyrimidine;
nucleoside analogue;
organofluorine compound;
pyrimidine antifungal drug;
pyrimidone		prodrug
sq 22536[no description available]low00nucleoside analogue;
oxolanes		EC 4.6.1.1 (adenylate cyclase) inhibitor
floxuridine[no description available]low00nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent
trifluridine[no description available]low00nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
EC 2.1.1.45 (thymidylate synthase) inhibitor
azacitidine[no description available]low00N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
nsc 65346[no description available]low00nucleoside analogueprotein kinase inhibitor
acadesine[no description available]low001-ribosylimidazolecarboxamide;
aminoimidazole;
nucleoside analogue		antineoplastic agent;
platelet aggregation inhibitor
stavudine[no description available]low00dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
isopentenyladenosine[no description available]low00N-ribosyl-N(6)-isopentenyladenine;
nucleoside analogue		antineoplastic agent;
plant growth regulator;
plant metabolite
fludarabine phosphate[no description available]low00nucleoside analogue;
organofluorine compound;
purine arabinonucleoside monophosphate		antimetabolite;
antineoplastic agent;
antiviral agent;
DNA synthesis inhibitor;
immunosuppressive agent;
prodrug
fazarabine[no description available]low00N-glycosyl-1,3,5-triazine;
nucleoside analogue		antineoplastic agent
lamivudine[no description available]low00monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
emtricitabine[no description available]low00monothioacetal;
nucleoside analogue;
organofluorine compound;
pyrimidone		antiviral drug;
HIV-1 reverse transcriptase inhibitor
triciribine[no description available]low00nucleoside analogueEC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
oxetanocin a[no description available]low00diol;
nucleoside analogue;
oxetanes;
primary alcohol		anti-HIV agent;
antibacterial agent;
bacterial metabolite
cyc 682[no description available]low00nitrile;
nucleoside analogue;
secondary carboxamide		antimetabolite;
antineoplastic agent;
DNA synthesis inhibitor;
prodrug
2-methylthio-n-6-isopentenyladenosine[no description available]low00nucleoside analogue
n(4)-hydroxycytidine[no description available]low00ketoxime;
nucleoside analogue		anticoronaviral agent;
antiviral agent;
drug metabolite;
human xenobiotic metabolite
tenofovir[no description available]low00nucleoside analogue;
phosphonic acids		antiviral drug;
drug metabolite;
HIV-1 reverse transcriptase inhibitor
4-demethylwyosine[no description available]low00nucleoside analogue
thiouridine[no description available]low00nucleoside analogue;
thiouridine		affinity label;
antimetabolite
2-thiouridine[no description available]low00nucleoside analogue;
thiouridine
zeatin riboside[no description available]low009-ribosylzeatin;
nucleoside analogue		cytokinin;
plant metabolite
fr 900848[no description available]low00cyclopropanes;
nucleoside analogue;
olefinic compound;
polyketide;
secondary carboxamide		antifungal agent;
bacterial metabolite
wyosine[no description available]low00carbamate ester;
methyl ester;
nucleoside analogue
allopurinol riboside[no description available]low00nucleoside analoguemetabolite
molnupiravir[no description available]low00isopropyl ester;
ketoxime;
nucleoside analogue		anticoronaviral agent;
antiviral drug;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials